| Sega Genesis cart. |  Madden NFL 95 Model 7376 | 1994 | EA Sports |
| Sega Genesis cart. | Madden NFL 96 | 1995 | EA Sports |
| Sega Genesis cart. | Madden NFL 97 | 1997 | EA Sports |
| Sega Genesis cart. | Madden NFL 98 | 1997 | EA Sports |
| Sega Genesis cart. | Mallet Legend's Whac-a-Critter Model 22011 | 1993 | Realtec Corp. |
| Sega Genesis cart. | Marble Madness Model 7089 P | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Mario Andretti Racing Model 7259 | 1994 | EA Sports |
| Sega Genesis cart. | Mario Lemieux Hockey | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Marko Model T-88086 | 1993 | Domark Group, Ltd. |
| Sega Genesis cart. |  Marsupilami Model 1841 | 1996 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Marvel Land | 1991 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | Mary Shelley's Frankenstein Model T-93086 | 1994 | Sony Imagesoft |
| Sega Genesis cart. | Master of Monsters Model 49156 | 1991 | Renovation Products USA |
| Sega Genesis cart. | Math Blaster - Episode 1 | 1994 | Davidson & Associates, Inc. |
| Sega Genesis cart. |  Matrix Runner | 199? | ZCT Systems Group |
| Sega Genesis cart. | Mazin Saga - Mutant Fighter Model T-23036 | 1993 | Vic Tokai, Inc. Torrance, CA, USA |
| Sega Genesis cart. | McDonald's Treasure Land Adventure | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Mega Bomberman Model 1573 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Mega Turrican Model T-13086 | 1994 | Data East USA, Inc. |
| Sega Genesis cart. | Meka Grappler X Hb | 2017 | Sik |
| Sega Genesis cart. | Menacer 6-Game Cartridge | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Mercs Model 1119 P | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Mick & Mack as the Global Gladiators Model T-70066 | 1992 | Virgin Games, Ltd. UK 013715 |
| Sega Genesis cart. | Mickey Mania - The Timeless Adventures of Mickey Mouse Model T-93156 | 1994 | Sony Imagesoft |
| Sega Genesis cart. | Mickey's Ultimate Challenge | 1994 | Hi-Tech Expressions, Inc. |
| Sega Genesis cart. | Micro Machines Model 15001 | 1993 | Codemasters Soft. Co., Ltd., The 015026 |
| Sega Genesis cart. | Midnight Resistance | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Mig-29 Fighter Pilot Model T-48166 | 1993 | Domark Group, Ltd. |
| Sega Genesis cart. | Might and Magic - Gates to Another World Model 7031 | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Might and Magic III - Isles of Terra | 1993 | FCI Fujisankei Communications International |
| Sega Genesis cart. | Mighty Morphin Power Rangers - The Movie | 1995 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Mighty Morphin Power Rangers Model 1570 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Mike Ditka Power Football | 1991 | Ballistic |
| Sega Genesis cart. | Miniplanets Hb | 2018 | Sik |
| Sega Genesis cart. |  Miniplanets demo | 2018 | Sik |
| Sega Genesis cart. | Miniplanets Remix Hb | 2022 | Sik |
| Sega Genesis cart. | Minnesota Fats - Pool Legend Model T-13106 | 1995 | Data East USA, Inc. |
| Sega Genesis cart. | Misplaced Hb | 2019 | RetroSouls |
| Sega Genesis cart. | MLB Sports Talk Baseball Model 1211 | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | MLBPA Baseball Model 7174 | 1992 | EA Sports |
