| Sega Mega-CD |  A-Rank Thunder Tanjouhen Model T-49064 | 1993 | Telenet Japan |
| Sega Mega-CD |  Advanced Dungeons & Dragons: Eye of the Beholder Model 4655-50 | 1994 | FCI Fujisankei Communications International |
| Sega Mega-CD | Advanced Dungeons & Dragons: Eye of the Beholder Model T-75014 | 1994 | Pony Canyon, Inc. Japan |
| Sega Mega-CD | After Armageddon Gaiden - Majuu Toushouden Eclipse Model G-6026 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | After Burner III Model 4415 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | After Burner III Model T-68014 | 1992 | CRI CSK Research Institute Japan |
| Sega Mega-CD | Aisle Lord Model T-32044 | 1992 | Wolf Team Japan |
| Sega Mega-CD | ALsharK Model T-92014 | 1993 | Polydor K.K. |
| Sega Mega-CD | Anett Futatabi Model T-32104 | 1993 | Wolf Team Japan |
| Sega Mega-CD | Aoki Ookami to Shiroki Mejika - Genchou Hishi Model T-76054 | 1993 | KOEI Co., Ltd. Japan |
| Sega Mega-CD | Arcus I-II-III Model T-32094 | 1993 | Wolf Team Japan |
| Sega Mega-CD | Arslan Senki - The Heroic Legend of Arslan Model G-6028 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | AX-101 Model G-6031 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Bakuden - The Unbalanced Zone Model T-145014 | 1994 | Sony Music Ent., Inc. Japan |
| Sega Mega-CD | Bari-Arm Model T-43024 | 1993 | Human Ent. Japan |
| Sega Mega-CD | Batman Returns Model 4401 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Battle Fantasy Model T-22044 | 1994 | Micronet Co., Ltd. Japan |
| Sega Mega-CD |  Battlecorps + SoulStar demo | 1994 | Core Design, Ltd. |
| Sega Mega-CD | Battlecorps - 3D Mechanical Battle Simulator Model T-60194 | 1994 | Victor Ent. Japan |
| Sega Mega-CD | Battlecorps demo | 1994 | Core Design, Ltd. |
| Sega Mega-CD | Battlecorps Model T-115045-50 | 1994 | Core Design, Ltd. |
| Sega Mega-CD | BC Racers demo | 1994 | Core Design, Ltd. |
| Sega Mega-CD | BC Racers Model T-115075-50 | 1994 | Core Design, Ltd. |
| Sega Mega-CD | Bill Walsh College Football Model T-50025-05 | 1993 | EA Sports |
| Sega Mega-CD | Black Hole Assault Model T-22024 | 1992 | Micronet Co., Ltd. Japan |
| Sega Mega-CD | Blackhole Assault Model 4405 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Bloodshot Model T-88045-50 | 1994 | Domark Group, Ltd. |
| Sega Mega-CD | Brutal - Paws of Fury Model T-83015-50 | 1994 | GameTek UK, Ltd. 026555 |
| Sega Mega-CD | Burai - Hachigyoku no Yuushi Densetsu Model G-6004 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Capcom no Quiz - Tonosama no Yabou Model T-44024 | 1992 | SIMS Co., Ltd. Japan |
| Sega Mega-CD | Captain Tsubasa Model T-36014 | 1994 | Tecmo, Ltd. Tokyo, Japan |
| Sega Mega-CD | Chuck Rock II - Son of Chuck Model T-115025-50 | 1993 | Core Design, Ltd. |
| Sega Mega-CD | Chuck Rock Model T-93045-50 | 1993 | Sony Imagesoft |
| Sega Mega-CD | Cobra Command Model 4402 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Corpse Killer Model T-162055-50 | 1994 | Digital Pictures |
| Sega Mega-CD | Cosmic Fantasy Stories Model T-49014 | 1992 | Telenet Japan |
| Sega Mega-CD | Cyborg 009 Model T-49054 | 1993 | Telenet Japan |
| Sega Mega-CD | Daihoushinden Model T-60024 | 1995 | Victor Ent. Japan |
| Sega Mega-CD | Dark Wizard - Yomigaeri Shiyami no Madoushi Model G-6005 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Death Bringer - Himerata Monshou - The Knight of Darkness Model T-49034 | 1992 | Telenet Japan |
