| Sega Mega-CD |  Road Blaster FX Model T-32124 | 1992 | Wolf Team Japan |
| Sega Mega-CD |  Robo Aleste Model 4416 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD |  Samurai Shodown demo | 1995 | JVC Musical Industries, Inc. |
| Sega Mega-CD | Samurai Shodown Model T-60175-50 | 1995 | JVC Musical Industries, Inc. |
| Sega Mega-CD | Sangokushi III Model T-76014 | 1993 | KOEI Co., Ltd. Japan |
| Sega Mega-CD | Sega Classics Arcade Collection Limited Edition Model 4127 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Sega Classics Arcade Collection Limited Edition Model G-6012 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Sega Pro CD Issue 42: Flashback - The Quest for Identity | 1994 | US Gold, Ltd. Birmingham, England 13442 |
| Sega Mega-CD | Seima Densetsu 3x3 Eyes Model G-6007 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Seirei Shinseiki - Fhey Area Model T-32034 | 1992 | Wolf Team Japan |
| Sega Mega-CD | Sengoku Densyo Model T-24034 | 1993 | Sammy Corp. Japan |
| Sega Mega-CD | Sensible Soccer demo | 1993 | Sony Computer Ent. Europe SCEE |
| Sega Mega-CD | Sensible Soccer Model T-93185-50 | 1993 | Sony Imagesoft |
| Sega Mega-CD | Sewer Shark Model T-93015-50 | 1992 | Sony Imagesoft |
| Sega Mega-CD | Shadow of the Beast II | 19?? | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Shadow of the Beast II - Juushin no Jubaku Model T-60034 | 1994 | Victor Ent. Japan |
| Sega Mega-CD | Shadowrun Model T-66024 | 1996 | Compile |
| Sega Mega-CD | Sherlock Holmes - Consulting Detective Vol. I Model 4650 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Sherlock Holmes - Consulting Detective Vol. II Model 4653 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Shin Megami Tensei Model T-44044 | 1994 | SIMS Co., Ltd. Japan |
| Sega Mega-CD | Shining Force CD Model 4656-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Shining Force CD Model G-6036 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Silpheed Hibaihin Model ST-45054 | 1993 | Game Arts Co., Ltd. Japan |
| Sega Mega-CD | Silpheed Model 4423 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Silpheed Model T-45054 | 1993 | Game Arts Co., Ltd. Japan |
| Sega Mega-CD | SimEarth Model G-6008 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Sing! Teddyboy Blues | 19?? | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Slam City with Scottie Pippen demo | 1994 | Digital Pictures |
| Sega Mega-CD | Slam City with Scottie Pippen Model T-162035-50 | 1994 | Digital Pictures |
| Sega Mega-CD | Snatcher Model T-95035-50 | 1994 | Konami Co., Ltd. Japan |
| Sega Mega-CD | Sol-Feace Model 4130 P | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Sol-Feace Model T-32024 P | 1991 | Wolf Team Japan |
| Sega Mega-CD | Sonic CD Model 4407 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Sonic the Hedgehog CD Hibaihin | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Sonic the Hedgehog CD Model G-6021 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | SoulStar demo | 1994 | Core Design, Ltd. |
| Sega Mega-CD | SoulStar Model T-115035-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | SoulStar Model T-60184 | 1994 | Victor Ent. Japan |
| Sega Mega-CD | Space Ace demo | 1994 | ReadySoft, Inc. Canada |
| Sega Mega-CD | Star Wars - Rebel Assault demo | 1994 | JVC Musical Industries, Inc. |
