| Sega Mega Drive cart. |  Sonic the Hedgehog | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Sonic the Hedgehog 2 Model 044130 | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Sonic the Hedgehog 2 Model 1051-40 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic the Hedgehog 2 Model 1051-50 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Sonic the Hedgehog 2 Model G-4088 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic the Hedgehog 3 Model 046190 | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Sonic the Hedgehog 3 Model 1079-40 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic the Hedgehog 3 Model 1079-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic the Hedgehog 3 Model G-5531 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic the Hedgehog Model 1009-50 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic the Hedgehog Model G-4049 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sorcer Kingdom Model T-25113 | 1992 | NCS Corp. Nippon Computer Systems Japan |
| Sega Mega Drive cart. | Sorcerian Model G-4504 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Space Funky B.O.B. | 1993 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Space Harrier II | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Space Harrier II Model G-4002 | 1988 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Space Invaders 90 Model T-11053 | 1990 | Taito Corp. Japan |
| Sega Mega Drive cart. | Sparkster - Rocket Knight Adventures 2 Model T-95103 | 1994 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | Sparkster Model T-95166-50 | 1994 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | Speedball 2 Model T-68023 | 1992 | CRI CSK Research Institute Japan |
| Sega Mega Drive cart. | Speedball 2 Model T-70086-50 | 1992 | Virgin Games, Ltd. UK 013715 |
| Sega Mega Drive cart. | Spider-Man & Venom - Maximum Carnage Model T-81256-50 | 1994 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Mega Drive cart. | Spirou Model T-151026-50 | 1996 | Infogrames Interactive, Inc. 329720 |
| Sega Mega Drive cart. | Splatterhouse 2 Model 670-2468-50 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Splatterhouse Part 2 Model T-14143 | 1992 | NAMCOT Japan |
| Sega Mega Drive cart. | Splatterhouse Part 3 Model T-14153 | 1993 | NAMCOT Japan |
| Sega Mega Drive cart. | Sport Games | 199? | Unknown |
| Sega Mega Drive cart. | Spot Goes to Hollywood Model T-70320-50 | 1996 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Mega Drive cart. | Squirrel King Model A179 | 1995 | Gamtec Taiwan |
| Sega Mega Drive cart. | Star Cruiser Model T-25063 | 1990 | NCS Corp. Nippon Computer Systems Japan |
| Sega Mega Drive cart. | Star Trek - Deep Space Nine - Crossroads of Time Model T-70436-50 | 1995 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Mega Drive cart. |  Star Trek - The Next Generation - Echoes from the Past | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Star Wars Jedi | 199? | Unknown |
| Sega Mega Drive cart. | Starflight | 1991 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Stargate | 1994 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Mega Drive cart. | Stargate Model FSTA15SMC | 199? | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Starwars | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Steel Talons | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Stimpy's Invention Starring Starring Ren Hoëk & Stimpy | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Stimpy's Invention Starring Starring Ren Hoëk & Stimpy Model FREN02SMC | 199? | SEGA OziSoft Australia |
