| Sega Mega Drive cart. |  Shinobi III - Return of the Ninja Master Model 044440 | 1993 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Shinobi III - Return of the Ninja Master Model 1136-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Shinobi III - Return of the Ninja Master Model FSHI05SMC | 199? | SEGA OziSoft Australia |
| Sega Mega Drive cart. |  Shiten-Myooh Model T-26023 | 1990 | Sigma Enterprises, Inc. Tokyo, Japan |
| Sega Mega Drive cart. | Shougi no Hoshi Model T-67013 | 1991 | Home Data Japan |
| Sega Mega Drive cart. | Show do Milhão Vol. 2 Model 053020 | 2002 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Show do Milhão Model 053010 | 2001 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Shrek 2 | 199? | Unknown |
| Sega Mega Drive cart. | Shui Hu - Feng Yun Zhuan | 1999 | Never Ending Soft Team |
| Sega Mega Drive cart. | Shui Hu Zhuan | 1996 | Chuanpu Technologies |
| Sega Mega Drive cart. | Shura no Mon Model G-4073 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Side Pocket Model 670-2893-50 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Side Pocket Model T-13083 | 1992 | Data East Corp. Japan |
| Sega Mega Drive cart. | Sink of Swim | 1994 | Codemasters Soft. Co., Ltd., The 015026 |
| Sega Mega Drive cart. | Skeleton Krew Model T-115036-50 | 1995 | Core Design, Ltd. |
| Sega Mega Drive cart. | Slam - Shaq vs. the Legends | 199? | Unknown |
| Sega Mega Drive cart. | Slap Fight MD Model T-48093 | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Slime World Model T-49123 | 1992 | Micro World |
| Sega Mega Drive cart. | Snake Rattle n' Roll | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Snezhnaya Koroleva | 199? | Unknown |
| Sega Mega Drive cart. | Snow Bros. - Nick & Tom Model T-48083 | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Soleil Model 1182-05 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Soleil Model 1182-06 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Soleil Model 1182-09 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Soleil Model 1182-18 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic & Knuckles Model 047090 | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Sonic & Knuckles Model 1563-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic & Knuckles Model G-4124 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic 3 Model 1079-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic 3D - Flickies' Island Model MK-1844-50 | 1996 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic 3D Blast Model 048300 | 1996 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Sonic Classics | 1997 | HiCom Korea |
| Sega Mega Drive cart. | Sonic Classics Model 042780 | 1997 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Sonic Compilation Model 1190-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Sonic Crackers | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic Spinball Model 044600 | 1993 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Sonic Spinball Model 1537-40 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic Spinball Model 1537-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sonic Spinball Model FSON05SMC | 1993 | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Sonic Spinball Model G-4112 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
