| Sega Mega Drive cart. |  Arcade Classics Model MK-1715-50 P | 1996 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Arcade's Greatest Hits Model T-97126-50 | 1996 | T-HQ, Inc. Toy HeadQuarters |
| Sega Mega Drive cart. | Arch Rivals - The Arcade Game Model T-81056-50 | 1992 | Flying Edge |
| Sega Mega Drive cart. |  Arcus Odyssey Model T-32053 | 1991 | Wolf Team Japan |
| Sega Mega Drive cart. | Arnold Palmer Tournament Golf Model 1203-50 | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Arrow Flash Model G-4039 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Art Alive Model G-4069 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Art of Fighting Model 1146-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Assault Suit LEYNOS Model T-25013 | 1990 | NCS Corp. Nippon Computer Systems Japan |
| Sega Mega Drive cart. | Astérix and the Great Rescue Model 045180 | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Astérix and the Great Rescue Model 1532-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Astérix and the Power of the Gods Model 1095-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Astérix and the Power of the Gods Model FAST06SMC | 199? | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Astérix et le Pouvoir des Dieux Model 010950F | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Atomic Robo-Kid Model T-24013 | 1990 | TRECO |
| Sega Mega Drive cart. | Atomic Runner Model 1144-50 | 1992 | Data East Corp. Japan |
| Sega Mega Drive cart. | ATP Tour Championship Tennis Model 1234-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Australian Rugby League | 1994 | EA Sports |
| Sega Mega Drive cart. | Awesome Possum | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Ayrton Senna's Super Monaco GP II | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Ayrton Senna's Super Monaco GP II Model G-5514 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Baby Boom | 199? | Unknown |
| Sega Mega Drive cart. | Back to the Future Part III Model T-69046-50 | 1991 | Image Works |
| Sega Mega Drive cart. | Bad Omen Model T-28043 | 1992 | Hot-B Japan |
| Sega Mega Drive cart. | Bahamut Senki Model G-4520 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ball Jacks Model T-14163 | 1993 | NAMCOT Japan |
| Sega Mega Drive cart. | Bao Xiao San Guo | 199? | C&E Computer & Ent., Inc. Taiwan |
| Sega Mega Drive cart. | Bare Knuckle - Ikari no Tekken Model G-4050 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Bare Knuckle II - Shitou he no Chingonka Model G-4091 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Bare Knuckle III Model G-4116 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Barver Battle Saga - Tai Kong Zhan Shi - Mo Fa Zhan Shi | 199? | Unknown |
| Sega Mega Drive cart. | Batman Model 1044-50 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Batman Model T-15043 | 1990 | SUNSOFT Kounan, Japan |
| Sega Mega Drive cart. | Battle Golfer Yui Model G-4040 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Battle Mania Daiginjou Model T-23043 | 1993 | Vic Tokai Japan |
| Sega Mega Drive cart. | Battle Mania Model T-23013 | 1992 | Vic Tokai Japan |
| Sega Mega Drive cart. | Battletoads Model 043260 | 1993 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Battletoads Model G-4074 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Beast Warriors Model T-49053 | 1991 | Riot Japan |
| Sega Mega Drive cart. |  Beastball | 199? | Spectrum HoloByte |
