| Sega Mega Drive cart. |  San Guo Yan Yi - Huo Shao Chi Bi | 199? | Unknown |
| Sega Mega Drive cart. | San Guo Zhi Lie Zhuan - Luan Shi Qun Ying | 199? | Unknown |
| Sega Mega Drive cart. | San Guo Zhi V | 199? | SKOB China |
| Sega Mega Drive cart. | San San Model T-147013 | 1994 | San San Co. |
| Sega Mega Drive cart. | Sangokushi II Model T-76023 | 1991 | KOEI Co., Ltd. Japan |
| Sega Mega Drive cart. | Sangokushi III Model T-76093 | 1992 | KOEI Co., Ltd. Japan |
| Sega Mega Drive cart. | Sangokushi Retsuden - Ransei no Eiyuutachi Model G-5504 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Saturday Night Slammasters Model T-12066-50 | 1994 | Capcom Co., Ltd. Japan |
| Sega Mega Drive cart. | Scholastic's The Magic School Bus | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Scrabble | 199? | Unknown |
| Sega Mega Drive cart. | SD Valis Model T-49103 | 1992 | Laser Soft |
| Sega Mega Drive cart. | SeaQuest DSV | 1994 | T-HQ, Inc. Toy HeadQuarters |
| Sega Mega Drive cart. | Second Samurai | 1994 | Psygnosis, Ltd. |
| Sega Mega Drive cart. | Sega Gold Collection: Street Fighter II' - Special Champion Edition | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sega Gold Collection: Wonder Boy in Monster Land Model FWON01SMC | 1992 | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Sega Sports 1 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sega Top Five | 199? | Unknown |
| Sega Mega Drive cart. | Senjou no Ookami II Model G-4051 P | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Sensible Soccer - International Edition Model T-93146-50 | 1993 | Sony Imagesoft |
| Sega Mega Drive cart. | Sensible Soccer Model T-93076-50 | 1993 | Renegade Soft. |
| Sega Mega Drive cart. | Sezon Ohoty | 199? | Unknown |
| Sega Mega Drive cart. | Sezon Ohoty 3 | 199? | Unknown |
| Sega Mega Drive cart. | Shadow Dancer - The Secret of Shinobi Model G-4043 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Shadow of the Beast - Mashou no Okite Model T-60023 | 1992 | Victor Musical Industries, Inc. Japan |
| Sega Mega Drive cart. | Shadowrun | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Shane Warne Cricket | 1997 | Codemasters Soft. Co., Ltd., The 015026 |
| Sega Mega Drive cart. | Shapes and Columns | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Shaq Fu Model E290 SMXI | 1994 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Shi Jie Zhi Bang Zheng Ba Zhan - World Pro Baseball 94 Model G-3041 | 1994 | C&E Computer & Ent., Inc. Taiwan |
| Sega Mega Drive cart. | Shi Liu Zhang Ma Jiang II 18 | 199? | Ming China |
| Sega Mega Drive cart. | Shijou Saidai no Soukoban Model T-25023 | 1990 | NCS Corp. Nippon Computer Systems Japan |
| Sega Mega Drive cart. | Shikinjou Model T-15053 | 1991 | SUNSOFT Kounan, Japan |
| Sega Mega Drive cart. | Shin Souseiki Ragnacenty Model G-5536 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Shining and the Darkness Model G-5506 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Shining Force - Kamigami no Isan Model G-5512 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Shining Force - The Legacy of Great Intention Model 1312-03 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Shining Force II - Koe no Fuuin Model G-5521 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Shining Force II Model 1315-03 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Shining in the Darkness Model 041260 | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Shining in the Darkness Model 1310-50 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
