| Sega Mega Drive cart. |  Rainbow Islands Extra Model T-11073 | 1990 | Taito Corp. Japan |
| Sega Mega Drive cart. | Rambo III | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Rampart Model T-48053 | 1992 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. |  Ranger-X Model 1076-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ransei no Hasha Model T-20053 | 1991 | Asmik Co., Ltd. Japan |
| Sega Mega Drive cart. | Rastan Saga II Model T-11043 | 1990 | Taito Corp. Japan |
| Sega Mega Drive cart. | Rent a Hero Model G-5508 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Resq | 199? | Psygnosis, Ltd. |
| Sega Mega Drive cart. | Richard Scarry's Busytown | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Rick Dangerous | 199? | Unknown |
| Sega Mega Drive cart. | Rings of Power Model E197SMXI | 1991 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Rise of the Robots Model T-81426-50 | 1994 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Mega Drive cart. | Ristar - The Shooting Star Model G-4126 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ristar Model 046550 | 1995 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Ristar Model 1555-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Road Busters | 1990 | Telenet Japan |
| Sega Mega Drive cart. | Road Rash 3 | 1995 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Road Rash II | 1993 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Road Rash Model E176SMX | 1991 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Road Rash Model EM20003 | 1991 | Electronic Arts Victor, Inc. Japan |
| Sega Mega Drive cart. | RoadBlasters Model T-48023 | 1992 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | RoboCop 3 Model T-81226-50 | 1993 | Flying Edge |
| Sega Mega Drive cart. | RoboCop versus The Terminator Model T-70043 | 1994 | Virgin Games, Ltd. UK 013715 |
| Sega Mega Drive cart. | RoboCop versus The Terminator Model T-70166-50 | 1994 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Mega Drive cart. | Rock n' Roll Racing | 1994 | Interplay |
| Sega Mega Drive cart. | Rocket Knight Adventures Model T-05046-50 | 1993 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | Rocket Knight Adventures Model T-95063 | 1993 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | Rockman Mega World Model T-12053 | 1994 | Capcom Co., Ltd. Japan |
| Sega Mega Drive cart. | Rockman X3 | 199? | Gamtec Taiwan |
| Sega Mega Drive cart. | Rolling Thunder 2 P | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Rolling Thunder 2 Model T-14133 P | 1991 | NAMCOT Japan |
| Sega Mega Drive cart. | Rolo to the Rescue | 1993 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Royal Blood Model T-76063 | 1992 | KOEI Co., Ltd. Japan |
| Sega Mega Drive cart. | Runark Model T-11153 | 1991 | Taito Corp. Japan |
| Sega Mega Drive cart. | Ryuuko no Ken Model G-4113 P | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | S.S. Lucifer - Man Overboard! Model T-120076 P | 1994 | Codemasters Soft. Co., Ltd., The 015026 |
| Sega Mega Drive cart. | Saint Sword Model T-11133 | 1991 | Taito Corp. Japan |
| Sega Mega Drive cart. | Same! Same! Same! Model T-40013 | 1990 | Toaplan Co., Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Samurai Shodown Model 1184-50 | 1994 | Takara Co., Ltd. Japan |
| Sega Mega Drive cart. | Samurai Spirits Model G-4127 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
