| Sega Mega Drive cart. |  Golden Axe II Model 1122-50 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Golden Axe II Model G-4062 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Golden Axe III Model G-4093 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Golden Axe Model G-4018 | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Gouketsuji Ichizoku Model T-144013 | 1994 | Atlus Co., Ltd. Japan |
| Sega Mega Drive cart. | Granada Model T-32023 | 1990 | Wolf Team Japan |
| Sega Mega Drive cart. | GrandSlam - The Tennis Tournament | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | GrandSlam - The Tennis Tournament '92 Model T-49133 | 1992 | Telenet Japan |
| Sega Mega Drive cart. | Great Circus Mystery - Mickey to Minnie Magical Adventure 2 | 1994 | Capcom Co., Ltd. Japan |
| Sega Mega Drive cart. | Greatest Heavyweights | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Gunship Model 79086-50 | 1993 | US Gold, Ltd. Birmingham, England 13442 |
| Sega Mega Drive cart. | Gunstar Heroes Model 044780 | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Gunstar Heroes Model 1077-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Gunstar Heroes Model G-4103 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Gynoug | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Gynoug Model T-25093 | 1991 | NCS Corp. Nippon Computer Systems Japan |
| Sega Mega Drive cart. | Hard Drivin' | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Hard Drivin' Model 301017-0170 | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Hard Drivin' Model T-48013 | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Harry Potter and the Chamber of Secrets | 199? | Unknown |
| Sega Mega Drive cart. | Heavy Unit - Mega Drive Special Model T-27013 P | 1990 | Toho Co., Ltd. Japan |
| Sega Mega Drive cart. | Hei Tao 2 - Super Big 2 | 199? | King Tec taiwan |
| Sega Mega Drive cart. | Hellfire Model 1137-50 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Hellfire Model T-25073 | 1990 | NCS Corp. Nippon Computer Systems Japan |
| Sega Mega Drive cart. | Herzog Zwei Model T-18023 | 1989 | Tecno Soft. TechnoSoft Japan |
| Sega Mega Drive cart. | Hokuto no Ken - Shin Seikimatsu Kyuuseishu Densetsu Model G-4012 | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Honoo no Toukyuuji - Dodge Danpei | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Hook | 1992 | Sony Imagesoft |
| Sega Mega Drive cart. | Hua Mu Lan - Mulan | 199? | Unknown |
| Sega Mega Drive cart. | Huan Le Tao Qi Shu - Smart Mouse Model GM-95401 | 199? | Ming China |
| Sega Mega Drive cart. | Hurricanes Model T-79136-50 | 1994 | US Gold, Ltd. Birmingham, England 13442 |
| Sega Mega Drive cart. | Hyokkori Hyoutan Jima - Daitouryou o Mezase! | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Hyper Dunk - The Playoff Edition Model T-95083 | 1994 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | Hyper Dunk Model T-95126-50 | 1994 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | Ice Age 4 | 200? | Unknown Russia |
| Sega Mega Drive cart. | Ichidant-R Model G-4128 P | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Indiana Jones - Koridory Vremeni | 199? | Unknown |
| Sega Mega Drive cart. | Indiana Jones and the Last Crusade - The Action Game | 1992 | US Gold, Ltd. Birmingham, England 13442 |
| Sega Mega Drive cart. | Insector X | 1990 | Hot-B Japan |
| Sega Mega Drive cart. | Instruments of Chaos Starring Young Indiana Jones | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
