| NEC PC-Engine CD |  Sangokushi Eiketsu - Tenka ni Nozomu | 1991 | Naxat Soft. Japan |
| NEC PC-Engine CD | Sangokushi III Model KOCD3003 | 1993 | KOEI Co., Ltd. Japan |
| NEC PC-Engine CD | Seirei Senshi Spriggan Model NXCD1004 | 1991 | Naxat Soft. Japan |
| NEC PC-Engine CD | Seiryuu Densetsu Monbit Model HCD1018 | 1991 | Hudson Soft. Hudson Group Japan |
| NEC PC-Engine CD | Seisenshi Denshou - Jantaku no Kishi | 1994 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| NEC PC-Engine CD |  Seiya Monogatari - Anearth Fantasy Stories Taikenban Model HMD-004 | 1995 | Hudson Soft. Hudson Group Japan |
| NEC PC-Engine CD | Seiya Monogatari - Anearth Fantasy Stories Model HCD5071 | 1995 | Hudson Soft. Hudson Group Japan |
| NEC PC-Engine CD | Sengoku Kantou Sangokushi | 1991 | Intec, Inc. Japan |
| NEC PC-Engine CD | Sexy Idol Mahjong - Fashion Monogatari | 1994 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| NEC PC-Engine CD | Sexy Idol Mahjong - Yakyuuken no Uta | 1995 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| NEC PC-Engine CD | Sexy Idol Mahjong Model NBCD3004 | 1993 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| NEC PC-Engine CD | Shadow of the Beast - Mashou no Okite Model JCCD2008 | 1992 | Victor Musical Industries, Inc. Japan |
| NEC PC-Engine CD | Shanghai II | 1990 | Hudson Soft. Hudson Group Japan |
| NEC PC-Engine CD | Shanghai III - Dragon's Eye | 1992 | ASK Kodansha Co., Ltd. Japan |
| NEC PC-Engine CD |  Shapeshifter - Makai Eiyuu Den Model JCCD2011 | 1992 | Victor Musical Industries, Inc. Japan |
| NEC PC-Engine CD | Sherlock Holmes no Tantei Kouza II | 1993 | Victor Ent. Japan |
| NEC PC-Engine CD | Sherlock Holmes no Tantei Kouza Model JCCD1004 | 1991 | Victor Musical Industries, Inc. Japan |
| NEC PC-Engine CD | Shiawase Usagi - Nureta Bishoujo Ichi Hajimete na no ni | 199? | Unknown Japan |
| NEC PC-Engine CD | Shiawase Usagi II - Toraware Usagi Sailor Z | 199? | Unknown Japan |
| NEC PC-Engine CD | Shin Megami Tensei Model ATCD3006 | 1993 | Atlus Co., Ltd. Japan |
| NEC PC-Engine CD | Shin Onryou Senki | 1995 | Fujicom |
| NEC PC-Engine CD | Shin Sangokushi - Tenka ha Ware ni | 1992 | Naxat Soft. Japan |
| NEC PC-Engine CD | Shinsetsu Shiawase Usagi | 1995 | Unknown Japan |
| NEC PC-Engine CD | Shinsetsu Shiawase Usagi 2 - Kairaku e no Invitation | 1996 | Unknown Japan |
| NEC PC-Engine CD | Shinsetsu Shiawase Usagi f - Yuujou Yori mo Aiyoku | 1997 | Unknown Japan |
| NEC PC-Engine CD | Shougi Database Kiyuu | 1995 | Seta Co., Ltd. Japan |
| NEC PC-Engine CD | SimEarth - The Living Planet | 1993 | Hudson Soft. Hudson Group Japan |
| NEC PC-Engine CD | Slime World Model MWCD2005 | 1992 | Micro World |
| NEC PC-Engine CD | Slot Shoubushi | 1995 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| NEC PC-Engine CD | Snatcher - Pilot Disk Model KMCD2001 | 1992 | Konami Co., Ltd. Japan |
| NEC PC-Engine CD | Snatcher Model KMCD2002 | 1992 | Konami Co., Ltd. Japan |
| NEC PC-Engine CD | Sol Bianca | 1990 | NCS Corp. Nippon Computer Systems Japan |
| NEC PC-Engine CD | Sol Moonarge Model ICCD3004 | 1994 | Irem Corp. Japan |
| NEC PC-Engine CD | Solid Force | 1995 | NEC Home Electronics, Ltd. |
| NEC PC-Engine CD | Sorcerian Model JCCD1005 | 1992 | Victor Musical Industries, Inc. Japan |
| NEC PC-Engine CD | Sotsugyou - Graduation Model NAPR-1036 | 1993 | NEC Avenue, Ltd. Japan |
| NEC PC-Engine CD | Sotsugyou II - Neo Generation | 1994 | Riverhill Soft. Japan |
| NEC PC-Engine CD | Sotsugyou Shashin - Miki Model CJCD-4005 | 1994 | Coconuts Japan |
| NEC PC-Engine CD |  Space Fantasy Zone | 1991 | NEC Avenue, Ltd. Japan |
| NEC PC-Engine CD | Space Invaders - The Original Game Model NAPR-1050 | 1995 | NEC Avenue, Ltd. Japan |
