| Sharp X68000 Series 5.25in. disk |  Datsugoku Game | 19?? | Deshita Soft |
| Sharp X68000 Series 5.25in. disk | DC Card | 1990 | Studio Undo |
| Sharp X68000 Series 5.25in. disk | De-Ja 18 | 1990 | Elf Japan |
| Sharp X68000 Series 5.25in. disk | De-Ja II | 1992 | Elf Japan |
| Sharp X68000 Series 5.25in. disk | De-Ja II for Adult 18 | 1992 | Elf Japan |
| Sharp X68000 Series 5.25in. disk | Dead of the Brain - Shiryou no Sakebi 18 | 1992 | IDES Japan |
| Sharp X68000 Series 5.25in. disk | Deadly Edge | 1997 | 6th Squad Projects |
| Sharp X68000 Series 5.25in. disk | Death Brade Model GS-164 P | 1992 | SPS Japan |
| Sharp X68000 Series 5.25in. disk | Death Bringer | 1989 | Telenet Japan |
| Sharp X68000 Series 5.25in. disk | Death Fighter v2 | 1992 | Battle Arts |
| Sharp X68000 Series 5.25in. disk | Deep Scan | 1989 | Tiny-Tomo |
| Sharp X68000 Series 5.25in. disk | Deep Scan | 19?? | Kin-Chan |
| Sharp X68000 Series 5.25in. disk | Deflektor | 1991 | BPS Bullet-Proof Soft. Japan |
| Sharp X68000 Series 5.25in. disk | Deg-on | 1990 | Pineapple Japan |
| Sharp X68000 Series 5.25in. disk | Delta Arm | 1990 | Login Soft. Japan |
| Sharp X68000 Series 5.25in. disk | Demon Slayer | 19?? | T&H Project |
| Sharp X68000 Series 5.25in. disk | Demon Slayer 2 | 19?? | T&H Project |
| Sharp X68000 Series 5.25in. disk | Demon Slayer 3 | 1991 | T&H Project |
| Sharp X68000 Series 5.25in. disk | Dennou Gakuen - Cybernetic Hi-School | 1990 | Gainax Japan |
| Sharp X68000 Series 5.25in. disk | Dennou Sakka - Cyber Writer Scenario Shuu 1 | 1988 | Nihon Computer Club Renmei Kikaku |
| Sharp X68000 Series 5.25in. disk | Dennou Sakka - Cyber Writer ver 2.0 | 1988 | Nihon Computer Club Renmei Kikaku |
| Sharp X68000 Series 5.25in. disk | DES Data Encryption Standard | 1993 | Wakatono |
| Sharp X68000 Series 5.25in. disk | Desperado | 199? | Kabosu |
| Sharp X68000 Series 5.25in. disk | Detana!! Twin Bee Model RA958 P | 1991 | Konami Industry Co., Ltd. Japan |
| Sharp X68000 Series 5.25in. disk | Devil Chain | 1990 | G-Limited |
| Sharp X68000 Series 5.25in. disk | Devil Chain 2 | 19?? | Unknown Japan |
| Sharp X68000 Series 5.25in. disk | Devil's a Letter of Invitation | 1994 | Joy Div. Japan |
| Sharp X68000 Series 5.25in. disk | Diamond Explorer | 19?? | Michael Co. Japan |
| Sharp X68000 Series 5.25in. disk | Diamond Explorer II | 1991 | Michael Co. Japan |
| Sharp X68000 Series 5.25in. disk | Die Banhwelt | 1992 | Glodia Co., Ltd. Japan |
| Sharp X68000 Series 5.25in. disk | Dig Dug | 19?? | Unknown Japan |
| Sharp X68000 Series 5.25in. disk | Dino Land | 1991 | Brother Kougyou Japan |
| Sharp X68000 Series 5.25in. disk | Dion | 1992 | Studio Theta |
| Sharp X68000 Series 5.25in. disk | Dios | 1990 | ZainSoft. Japan |
| Sharp X68000 Series 5.25in. disk | Direct-X | 199? | PYX Japan |
| Sharp X68000 Series 5.25in. disk | Disco Scroll | 1989 | Mugen Kaisha Rana |
| Sharp X68000 Series 5.25in. disk | Disk Bishoujo Dai Zukan 18 | 1992 | Santa Fe Japan |
| Sharp X68000 Series 5.25in. disk | Dive On | 1993 | MIX Japan |
| Sharp X68000 Series 5.25in. disk | Dive On 2 | 1995 | MIX Japan |
| Sharp X68000 Series 5.25in. disk | Doctor | 198? | Artdink Corp. Japan |
