| Slot Machine |  Easy Hold | 2003 | WMS Gaming, Inc. Chicago, IL, USA |
| Nintendo GBA cart. | Ed, Edd n Eddy - Jawbreakers! Model AGB-AE3E-USA | 2003 | BAM! Ent. |
| Nintendo GBA cart. | Ed, Edd n Eddy - Jawbreakers! Model AGB-AE3P | 2003 | BAM! Ent. |
| Arcade Video game | ee'mall 1st Avenue | 2003 | Konami Corp. Japan |
| Arcade Video game | ee'mall 2nd Avenue | 2003 | Konami Corp. Japan |
| Slot Machine | Egyptagon II | 2003 | Konami Corp. Japan |
| Slot Machine | Egyptian King | 2003 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Sony PlayStation 2 disc |  eJay Clubworld - The Music Making Experience Model SLUS-20525 | 2003 | Crave Ent., Inc. |
| LeapFrog Leapster cart. | El Laberinto de las Letras | 2003 | LeapFrog |
| Pachislot | Eldoura 7 | 2003 | Bellco Corp. Japan |
| Acorn Electron 3.5in. disk | Electron User Group #63 | 2003 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #63 | 2003 | EUG Electron User Group |
| Acorn Electron 3.5in. disk | Electron User Group #64 | 2003 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #64 | 2003 | EUG Electron User Group |
| Slot Machine | Elegant Emeralds | 2003 | IGT International Game Technologies Reno, NV, USA |
| Sony PlayStation CD | Elemental Pinball Model SLES-04038 | 2003 | Midas Int. Ent. |
| PC/MS-Windows CD | Emergency 2 - The Ultimate Fight for Life | 2003 | Take-Two Interactive |
| PC/MS-Windows CD | Emergency Fire Response | 2003 | DreamCatcher Interactive |
| PC/MS-Windows CD | Empires - Dawn of the Modern World | 2003 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Slot Machine | Enchanted Fortunes | 2003 | WMS Gaming, Inc. Chicago, IL, USA |
| Slot Machine | Enjoy Wild | 2003 | Subsino Co., Ltd. |
| Takara e-Kara cart. | Enka Taizen Dai San-hen Model EC0085-ETZ | 2003 | Takara Co., Ltd. Japan |
| PC/MS-Windows CD | Enter the Matrix | 2003 | Atari Interactive, Inc. |
| Microsoft XBOX disc | Enter the Matrix | 2003 | Unknown |
| Nintendo GameCube disc | Enter the Matrix Model DOL-GMXE-USA | 2003 | Atari, Inc. NY, USA |
| Nintendo GameCube disc | Enter the Matrix Model DOL-GMXP-EUR | 2003 | Atari Europe S.A.S.U. |
| Sony PlayStation CD | Equestriad 2001 Model SLES-02943 | 2003 | Midas Int. Ent. |
| Sony PlayStation CD | Equestrian Showcase Model SLUS-01462 | 2003 | Mud Duck Productions |
| Slot Machine | ER Fever | 2003 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Sega Dreamcast GD | Erde - Nezu no Ki no Shita de Model T-19720M | 2003 | KID Kindle Imagine Develop |
| Microsoft XBOX disc | Escape 03 | 2003 | Unknown |
| Arcade Video game | Espgaluda | 2003 | Cave Co., Ltd. Japan |
| Microsoft XBOX disc | ESPN College Hoops | 2003 | Unknown |
| Microsoft XBOX disc | ESPN NBA Basketball | 2003 | Unknown |
| Microsoft XBOX disc | ESPN NFL Football | 2003 | Unknown |
| Microsoft XBOX disc | ESPN NHL Hockey | 2003 | Unknown |
| Sony PlayStation 2 disc | ESPN NHL Hockey Model SLES-51948 | 2003 | SEGA Corp. |
| PC/MS-Windows CD | Etherlords II | 2003 | Strategy First |
| GamePark GP32 cart. | Eunhaengnamu Sonyeo Mil | 2003 | GamePark |
| PC/MS-Windows CD | Euratchacha Mu Daeri P | 2003 | Wizard Soft Korea |
