| Sony PlayStation 4 BR |  Senran Kagura Burst Re:Newal Model PLJM-16074 | 2018 | Marvelous Ent., Inc. |
| PC/MS-Windows pack. | SEUM - Speedrunners from Hell | 2018 | GOG sp. z o.o. |
| PC/MS-Windows CD | Shadow of the Tomb Raider | 2018 | Square Enix Co., Ltd. Japan |
| PC/MS-Windows pack. |  Shadow of the Tomb Raider Trial Model 974630 | 2018 | Steam Valve Corp. |
| PC/MS-Windows pack. | Shadow of the Tomb Raider Model 750920 | 2018 | Steam Valve Corp. |
| Apple tvOS pack. | Shadowgun - Legends | 2018 | Unknown |
| PC/MS-Windows CD | Shadows - Awakening | 2018 | Kalypso Media GmbH |
| PC/MS-Windows pack. | Shadows - Awakening | 2018 | GOG sp. z o.o. |
| Nintendo Switch cart. | Shanghai Refresh | 2018 | SUNSOFT Kounan, Japan |
| Sony PlayStation 4 BR | Shantae - Half Genie Half Hero Ultimate Edition Model PLJM-16165 | 2018 | Oizumi Amuzio Japan |
| Nintendo Switch cart. |  Shantae - Half-Genie Hero - Ultimate Edition | 2018 | XSEED Games |
| Nintendo Switch cart. | Shantae - Half-Genie Hero - Ultimate Edition Model LA-H-AMSGA-EUR | 2018 | PQube, Ltd. |
| Nintendo Switch cart. | Shantae - Half-Genie Hero - Ultimate Edition Model LA-H-AMSGB-JPN | 2018 | Oizumi Amuzio Japan |
| PC/MS-Windows pack. | Shantae - Half-Genie Hero Ultimate Edition | 2018 | GOG sp. z o.o. |
| Nintendo Switch cart. | Shantae and the Pirate's Curse | 2018 | Limited Run Games |
| PC/MS-Windows pack. | Shaq Fu - A Legend Reborn | 2018 | GOG sp. z o.o. |
| PC/MS-Windows pack. | Shards of Eradine Model 804830 | 2018 | Steam Valve Corp. |
| Nintendo Switch cart. | Shelter Generations | 2018 | Super Rare Games |
| Sony PlayStation 4 BR | Shenmue I & II Model CUSA-10559 | 2018 | SEGA Holdings Co., Ltd. |
| PC/MS-Windows pack. | Sherlock Holmes - The Devil's Daughter | 2018 | GOG sp. z o.o. |
| Sony PlayStation 4 BR | Shiawase sou no Kanrijin-san Model PLJS-70054 | 2018 | D3 Publisher, Inc. |
| Nintendo Switch cart. | Shiin Model LA-H-AN62A-JPN | 2018 | Experience, Inc. Japan |
| Nintendo Switch cart. | Shikhondo - Soul Eater Model EAS-SW003 | 2018 | EastAsiaSoft |
| Google Play pack. | Shin Megami Tensei Dx2 | 2018 | SEGA Corp. |
| Nintendo Switch cart. | Shin Sangoku Musou 7 with Moushouden DX | 2018 | KOEI Tecmo Games Co., Ltd. Japan |
| Sony PlayStation 4 BR | Shin Sangoku Musou 8 Model PLJM-16080 | 2018 | KOEI Tecmo Games Co., Ltd. Japan |
| Pachinko | Shin-Hana no Keiji 2 | 2018 | Newgin Japan |
| Sony PS Vita game | Shingeki no Kyojin 2 | 2018 | KOEI Tecmo Games Co., Ltd. Japan |
| Nintendo Switch cart. | Shingeki no Kyojin 2 Model LA-H-AECNA-JPN | 2018 | KOEI Tecmo Games Co., Ltd. Japan |
| Sony PlayStation 4 BR | Shingeki no Kyojin 2 Model PLJM-16163 | 2018 | KOEI Tecmo Games Co., Ltd. Japan |
| Google Play pack. | Shining Force Classics | 2018 | SEGA Corp. |
| Nintendo Switch cart. | Shining Resonance Re:frain Model LA-H-AM7TA-JPN | 2018 | SEGA Corp. |
| Sony PlayStation 4 BR | Shining Resonance Model PLJM-80269 | 2018 | SEGA Holdings Co., Ltd. |
| PC/MS-Windows pack. | Shining Song Starnova | 2018 | GOG sp. z o.o. |
| PC/MS-Windows pack. | Shining Song Starnova Limited Edition | 2018 | GOG sp. z o.o. |
| Sony PlayStation 4 BR | Shinobi, Koutsutsu - Man Hana Irodori Emaki | 2018 | Idea Factory Co., Ltd. Japan |
| Pachislot | Shinseiki Evangelion - Magokoro 2 | 2018 | Bisty Japan |
| Google Play pack. | Shisen Sho Mahjong Connect | 2018 | Mobirix |
| PC/MS-Windows pack. | Shivers | 2018 | GOG sp. z o.o. |
| Gun video game | Shoot Away Pro | 2018 | Bandai NAMCO Ent., Inc. |
