| PC/MS-Windows CD |  Shamans Sanctuary - Miko no Seiki | 2010 | Alicesoft Japan |
| Slot Machine | Shambala | 2010 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Shaolin Legends | 2010 | WMS Gaming, Inc. Chicago, IL, USA |
| Arcade Video game | Shark | 2010 | 3D Group, Ltd. China |
| Slot Machine | Sheer Magic | 2010 | Ainsworth Game Technology, Ltd. |
| Redemption mechanical game | Shen Qi Zhang Yu | 2010 | Richuang Technology Dev. Co., Ltd. Guangdong, China |
| Slot Machine | Sherlock at the Murder Mansion | 2010 | ID Interactive |
| PC/MS-Windows pack. | Sherlock Holmes - Secret of the Silver Earring | 2010 | GOG sp. z o.o. |
| Sony PSN: Shodai PS Archives pack. |  Shin Megami Tensei - Devil Children Model NPJI-????? | 2010 | Atlus Co., Ltd. Japan |
| Sony PSN: Shodai PS Archives pack. | Shin Megami Tensei if... Model NPJI-????? | 2010 | Atlus Co., Ltd. Japan |
| Sony PSN: Shodai PS Archives pack. | Shin Megami Tensei II Model NPJI-????? | 2010 | Atlus Co., Ltd. Japan |
| Sony PSN: Shodai PS Archives pack. | Shin Megami Tensei Model NPJI-????? | 2010 | Atlus Co., Ltd. Japan |
| Sony PSP UMD |  Shin Megami Tensei: P3P - Persona 3 Portable Model ULUS-10512 | 2010 | Atlus USA, Inc. CA, USA |
| PC/MS-Windows CD | Ship Simulator Extremes | 2010 | Paradox Interactive |
| Medal video game | Shippe Jungle | 2010 | Amuzy Japan |
| Sony PlayStation 3 disc | Shirokishi Monogatari - Hikari to Yami no Kakusei Model BCJS-30042 | 2010 | Sony Computer Ent., Inc. SCEI Japan |
| Coin-op Misc. game | Shooter Twin 2010 | 2010 | RS Co., Ltd. |
| Sega Beena cart. | Shooting Beena Toy Story 3 - Woody to Buzz no Daibouken! | 2010 | SEGA Toys |
| VTECH V.Smile Motion cart. | Shrek 4 - Il Etait une Fin Model 80-084505 | 2010 | VTECH Video Technology, Ltd. |
| VTECH V.Smile Motion cart. | Shrek Felices para siempre Model 80-084507 | 2010 | VTECH Video Technology, Ltd. |
| Microsoft XBOX 360 disc | Shrek Forever After - The Final Chapter | 2010 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Sony PlayStation 3 disc | Shrek Forever After - The Final Chapter Model BLES-00837 | 2010 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| PC/MS-Windows pack. | Sid Meier's Civilization V Model 8930 | 2010 | Steam Valve Corp. |
| Sinclair ZX Spectrum cass. | Sid Spanners Hb | 2010 | Digital Prawn |
| Sony PSP UMD | Silent Hill - Shattered Memories Model ULUS-10450 | 2010 | Konami Digital Ent. Co., Ltd. |
| PC/MS-Windows CD | Silent Hunter 5 - Battle of the Atlantic | 2010 | Ubisoft Ent. Montreuil sous Bois, France |
| Sony PSN: Shodai PS Archives pack. | Silhouette Mirage Model NPJI-????? | 2010 | Treasure |
| Redemption mechanical game | Silver Rush | 2010 | Shoken Showa Giken |
| Sony PSN: PSone Classics pack. | Sim Theme Park Model NPUJ-????? | 2010 | Electronic Arts CA, USA 14633 |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 100: The Uchuhikoshi Model NPJI-????? | 2010 | D3 Publisher, Inc. |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 101: The Sento Model NPJI-????? | 2010 | D3 Publisher, Inc. |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 14: The Block Kuzushi Model NPJI-????? | 2010 | D3 Publisher, Inc. |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 15: The Pachinko Model NPJI-????? | 2010 | D3 Publisher, Inc. |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 18: The Bowling Model NPJI-????? | 2010 | D3 Publisher, Inc. |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 28: The Dungeon RPG Model NPJI-????? | 2010 | D3 Publisher, Inc. |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 31: The Sound Novel Model NPJI-????? | 2010 | D3 Publisher, Inc. |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 32: The Boxing Model NPJI-????? | 2010 | D3 Publisher, Inc. |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 33: The Takkyu Model NPJI-????? | 2010 | D3 Publisher, Inc. |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 35: The Shooting Model NPJI-????? | 2010 | D3 Publisher, Inc. |
| Sony PSN: Shodai PS Archives pack. | Simple 1500 Series Vol. 36: The Renai Simulation Model NPJI-????? | 2010 | D3 Publisher, Inc. |
