| Nintendo Switch cart. |  Root Letter - Last Answer | 2018 | Kadokawa Games, Ltd. Japan |
| Nintendo Switch cart. | Rorona no Atelier - Arland no Renkinjutsushi DX Model LA-H-AQYTA-JPN | 2018 | KOEI Tecmo Games Co., Ltd. Japan |
| Nintendo Switch cart. | RPG Maker MV - Trinity | 2018 | Kadokawa Games, Ltd. Japan |
| Nintendo Switch cart. | Runbow | 2018 | Merge Games |
| Nintendo Switch cart. | RXN Raijin Model EAS-SW002 | 2018 | EastAsiaSoft |
| Nintendo Switch cart. | SaGa: Scarlet Grace - Hiiro no Yabou Model LA-H-AP8HA-JPN | 2018 | Square Enix Co., Ltd. Japan |
| Nintendo Switch cart. | Salt and Sanctuary | 2018 | Leadman Games |
| Nintendo Switch cart. | Sangoku Rensenki - Otome no Heihou! | 2018 | Prototype Japan |
| Nintendo Switch cart. | SD Gundam G Generation Genesis Model LA-H-AMSTA-JPN | 2018 | Bandai NAMCO Ent., Inc. |
| Nintendo Switch cart. | Senjou no Valkyria 4 Model LA-H-APSBA-JPN | 2018 | SEGA Corp. |
| Nintendo Switch cart. | Shanghai Refresh | 2018 | SUNSOFT Kounan, Japan |
| Nintendo Switch cart. |  Shantae - Half-Genie Hero - Ultimate Edition | 2018 | XSEED Games |
| Nintendo Switch cart. | Shantae - Half-Genie Hero - Ultimate Edition Model LA-H-AMSGA-EUR | 2018 | PQube, Ltd. |
| Nintendo Switch cart. | Shantae - Half-Genie Hero - Ultimate Edition Model LA-H-AMSGB-JPN | 2018 | Oizumi Amuzio Japan |
| Nintendo Switch cart. | Shantae and the Pirate's Curse | 2018 | Limited Run Games |
| Nintendo Switch cart. | Shelter Generations | 2018 | Super Rare Games |
| Nintendo Switch cart. | Shiin Model LA-H-AN62A-JPN | 2018 | Experience, Inc. Japan |
| Nintendo Switch cart. | Shikhondo - Soul Eater Model EAS-SW003 | 2018 | EastAsiaSoft |
| Nintendo Switch cart. | Shin Sangoku Musou 7 with Moushouden DX | 2018 | KOEI Tecmo Games Co., Ltd. Japan |
| Nintendo Switch cart. | Shingeki no Kyojin 2 Model LA-H-AECNA-JPN | 2018 | KOEI Tecmo Games Co., Ltd. Japan |
| Nintendo Switch cart. | Shining Resonance Re:frain Model LA-H-AM7TA-JPN | 2018 | SEGA Corp. |
| Nintendo Switch cart. | Sid Meier's Civilization VI | 2018 | 2K Games, Inc. New York, NY, USA |
| Nintendo Switch cart. | Slain - Back from Hell | 2018 | Merge Games |
| Nintendo Switch cart. | Slime-san - Superslime Edition | 2018 | Limited Run Games |
| Nintendo Switch cart. | SNK Heroines - Tag Team Frenzy Model LA-H-APVSA-JPN | 2018 | SNK Corp. Shin Nihon Kikaku Japan |
| Nintendo Switch cart. | Sonic Mania Plus | 2018 | SEGA Corp. |
| Nintendo Switch cart. | Sports Party Model LA-H-AFVXA-USA | 2018 | Ubisoft, Inc. San Francisco, CA, USA 08888 |
| Nintendo Switch cart. | Starlink - Battle for Atlas Model LA-H-AD8HA-UKV | 2018 | Ubisoft Ent. Montreuil sous Bois, France |
| Nintendo Switch cart. | Starlink - Battle for Atlas Model LA-H-AD8HA-USA | 2018 | Ubisoft, Inc. San Francisco, CA, USA 08888 |
| Nintendo Switch cart. | SteamWorld Dig 2 Model LA-H-ACATC-UKV | 2018 | Rising Star Games, Ltd. UK |
| Nintendo Switch cart. | Steins;Gate Elite Model HAC-AMNPA-JPN | 2018 | 5pb. Japan |
| Nintendo Switch cart. | Steins;Gate Elite Model HAC-AMNPB-USA | 2018 | Spike Chunsoft Japan |
| Nintendo Switch cart. | Steredenn - Binary Stars | 2018 | Super Rare Games |
| Nintendo Switch cart. | Street Fighter - 30th Anniversary Collection | 2018 | Capcom Co., Ltd. Japan |
| Nintendo Switch cart. | Sumikko Gurashi - Atsumare! Sumikko Town | 2018 | Nippon Columbia |
| Nintendo Switch cart. | Super Chariot Model LA-H-AFLLA-EUR | 2018 | Microïds |
| Nintendo Switch cart. | Super Mario Party Model LA-H-ADFJA-JPN | 2018 | Nintendo Co., Ltd. Japan |
| Nintendo Switch cart. | Super Smash Bros. Ultimate Model LA-H-AAABA-UKV | 2018 | Nintendo Co., Ltd. Japan |
| Nintendo Switch cart. | Super Smash Bros. Ultimate Model LA-H-AAABA-USA | 2018 | Nintendo of America, Inc. USA 45496 |
| Nintendo Switch cart. | Sushi Striker - The Way of Sushido Model LA-H-ALA2B-UKV | 2018 | Nintendo Co., Ltd. Japan |
