| MSX 2 disk |  Majinkyuu Model MXZS-12009 | 1988 | Xain Soft. Japan |
| MSX 2 disk | Master of Monsters | 1988 | SystemSoft Corp. Japan |
| MSX 2 disk | Mei Tantei Numarin - The Private Detective | 1988 | ARE System Japan |
| MSX 2 disk | Misty | 1988 | Champion Soft. Japan |
| MSX 2 disk | Monoris | 1988 | Purom Japan |
| MSX 2 disk | MSX-FAN Fandom Library 4 | 1988 | Tokuma Shoten Intermedia, Inc. Japan |
| MSX 2 disk | MSX-FAN Fandom Library 5 | 1988 | Tokuma Shoten Intermedia, Inc. Japan |
| MSX 2 disk | Nihongo Waupuro Bunsho Sakuzaemon | 1988 | Sony Corp. Japan |
| MSX 2 disk | Ninja | 1988 | Bothtec, Inc. Japan |
| MSX 2 disk | Nukenin Densetsu - Tsubasa o Motta Otoko-tachi | 1988 | Brain Gray Co., Ltd. Japan |
| MSX 2 disk | Nukenin Densetsu Bangai-hen - Yami Kara no Houmonsha | 1988 | Brain Gray Co., Ltd. Japan |
| MSX 2 disk | Onryou Senki | 1988 | Soft Studio Wing Japan |
| MSX 2 disk | Pana Amusement Collection Disc | 1988 | Panasoft |
| MSX 2 disk | Pension Story - Hana no Kiyosato | 1988 | Panther Soft. Japan |
| MSX 2 disk | Phantasie II - Ferronrah no Shu | 1988 | Bothtec, Inc. Japan |
| MSX 2 disk | Phantasie Model MSG-04 | 1988 | Bothtec, Inc. Japan |
| MSX 2 disk | Pro Yakyuu FAN Telenet Stadium | 1988 | Telenet Japan |
| MSX 2 disk | Psy-O-Blade Model TEM-89 | 1988 | T&E Soft. Japan |
| MSX 2 disk | Psycho World | 1988 | Hertz Japan |
| MSX 2 disk | Quinpl | 1988 | Bit2 Japan |
| MSX 2 disk | R.A.D.X.-8 | 1988 | Philips Interactive Media, Inc. |
| MSX 2 disk | Rock'n Roller | 1988 | Unknown Japan |
| MSX 2 disk | Sa-Zi-Ri | 1988 | Telenet Japan |
| MSX 2 disk | Saotome Military Academy of U.N. Space Force Nyuugaku Annai | 1988 | Studio Angel Japan |
| MSX 2 disk | Seiha Model NM-01 | 1988 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| MSX 2 disk | Seilane Model 73344 | 1988 | Micro Cabin Co. Japan |
| MSX 2 disk | Senno Knife no Mashoujo Kan | 1988 | I-Cell |
| MSX 2 disk | Shadow Hunter | 1988 | Champion Soft. Japan |
| MSX 2 disk | Shin Kugyokuden Model MXTJ-12005 | 1988 | Tecno Soft. TechnoSoft Japan |
| MSX 2 disk | Shin Maou Golvellius | 1988 | Compile |
| MSX 2 disk | Shitai Okiba de Yuushoku wo Model 98MXD-4 | 1988 | Heart Soft. Japan |
| MSX 2 disk | Snatcher Model RA004 | 1988 | Konami Industry Co., Ltd. Japan |
| MSX 2 disk | Solitaire Royale Model GA8FM2 | 1988 | Game Arts Co., Ltd. Japan |
| MSX 2 disk | Star Ship Rendezvous | 1988 | ScapTrust Japan |
| MSX 2 disk | Super Daisenryaku Model 85144 | 1988 | Micro Cabin Co. Japan |
| MSX 2 disk | Tanba Model 41511 | 1988 | Micronet Co., Ltd. Japan |
| MSX 2 disk | Tenshitachi no Gogo II - Minako | 1988 | Jast Japan |
| MSX 2 disk | Testament | 1988 | Basho House Japan |
| MSX 2 disk | Tetris Model MXBP-12002 | 1988 | BPS Bullet-Proof Soft. Japan |
| MSX 2 disk | The 4th Unit 2 | 1988 | Data West, Inc. Japan |
