| MSX 2 disk |  Dokkin Minako Sensei | 1988 | Tect House Japan |
| MSX 2 disk | Dungeon Manjirou | 1988 | MSX Magazine Japan |
| MSX 2 disk | Dynamic Publisher | 1988 | RB Soft. Spain |
| MSX 2 disk | Ease - Philips Desktop | 1988 | Philips Interactive Media, Inc. |
| MSX 2 disk | Feedback | 1988 | Tecno Soft. TechnoSoft Japan |
| MSX 2 disk | Final Countdown | 1988 | Methodic Solutions |
| MSX 2 disk | Gaia no Monshou | 1988 | NCS Corp. Nippon Computer Systems Japan |
| MSX 2 disk | Gakuen Monogatari - High School Story | 1988 | Great Japan |
| MSX 2 disk | Gakuen Senki | 1988 | Champion Soft. Japan |
| MSX 2 disk | Gandhara - Buddha no Seisen Model E-G214 | 1988 | Enix, Ltd. Japan |
| MSX 2 disk | Gekisou Nyancle - Nyancle Racing | 1988 | Bit2 Japan |
| MSX 2 disk | Gokudou Jintori Model 41512 | 1988 | Micronet Co., Ltd. Japan |
| MSX 2 disk | Greatest Driver Model TEM-94 | 1988 | T&E Soft. Japan |
| MSX 2 disk | Gulliver | 1988 | Computer Brain Japan |
| MSX 2 disk | Gunjin Shougi | 1988 | Pack-In-Video Co., Ltd. Japan |
| MSX 2 disk | Herzog Model MXTJ-12003 | 1988 | Tecno Soft. TechnoSoft Japan |
| MSX 2 disk | Hitomi Kobayashi - Puzzle in London Model INF-01M | 1988 | Informercial |
| MSX 2 disk | How Many Robot | 1988 | Artdink Corp. Japan |
| MSX 2 disk | Ifr-Fly | 1988 | Philips Interactive Media, Inc. |
| MSX 2 disk | Isseki ni Kakeru Seishun | 1988 | LOG Japan |
| MSX 2 disk | J.B. Harold Jikenbo #1: Final Mystery - Murder Club Model 81144 | 1988 | Micro Cabin Co. Japan |
| MSX 2 disk | J.B. Harold Series #2: Manhattan Requiem - Angels Flying in the Dark Model MXRH-12001 | 1988 | Riverhill Soft. Japan |
| MSX 2 disk | Jipshi | 1988 | Champion Soft. Japan |
| MSX 2 disk | Joker | 1988 | Birdy Soft. Japan |
| MSX 2 disk | Jotunn Model MXZS-12010 | 1988 | Xain Soft. Japan |
| MSX 2 disk | Kaijuu Daisensou T.D.F. - Kesshi no Genshirou Bouei Sakusen | 1988 | Data West, Inc. Japan |
| MSX 2 disk | Kidou Senshi Gundam - MS Field | 1988 | Family Soft. Japan |
| MSX 2 disk | Kimagure Orange Road - Natsu no Mirage Model 84344 | 1988 | Micro Cabin Co. Japan |
| MSX 2 disk | Kiss of Murder - Satsui no Seppun | 1988 | Riverhill Soft. Japan |
| MSX 2 disk | Kon'yamo Asamade Powerful Mahjong 2 Model MS2-G5120-P1 | 1988 | DB-SOFT Japan |
| MSX 2 disk | Konami no Uranai Sensation Model RA003 | 1988 | Konami Industry Co., Ltd. Japan |
| MSX 2 disk | Kudokikata Oshiemasu 18 | 1988 | Hard Japan |
| MSX 2 disk | Kudokikata Oshiemasu Part-II - Kind Gal's | 1988 | Hard Japan |
| MSX 2 disk | Kujaku Ou Model L58Y-5113 | 1988 | Pony Canyon, Inc. Japan |
| MSX 2 disk | Last Armageddon | 1988 | Brain Gray Co., Ltd. Japan |
| MSX 2 disk | Last Armaggedon - Alien Zukan | 1988 | Brain Gray Co., Ltd. Japan |
| MSX 2 disk | Little Vampire Model MXCP-12010 | 1988 | Champion Soft. Japan |
| MSX 2 disk | M.U.L.E. Model MXBP-12001 | 1988 | BPS Bullet-Proof Soft. Japan |
| MSX 2 disk | Madonna no Yuuwaku | 1988 | Dot Kikaku Japan |
| MSX 2 disk | Maison Ikkoku Kanketsu-Hen - Sayonara Soshite Model 82544 | 1988 | Micro Cabin Co. Japan |
