| Sony PlayStation CD |  Dynamite Soccer 2000 Model SLPS-02554 | 2000 | A-Max Japan |
| Sony PlayStation CD |  EA Sports Superbike 2000 Model SLES-02538 | 2000 | EA Sports |
| Sony PlayStation CD | EA Sports Superbike 2000 Model SLUS-01052 | 2000 | EA Sports |
| Sony PlayStation CD | EA Sports Supercross Model SLUS-01319 | 2000 | EA Sports |
| Sony PlayStation CD | Eagle One - Harrier Attack Model SLES-01715 | 2000 | Infogrames Europe 546430 |
| Sony PlayStation CD | ECW Anarchy Rulz Model SLES-02823 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | ECW Anarchy Rulz Model SLES-03069 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | ECW Anarchy Rulz Model SLUS-01169 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD |  ECW Hardcore Revolution - Trade Demo Model SLUS-81045 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | ECW Hardcore Revolution Model SLES-02535 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | ECW Hardcore Revolution Model SLES-02536 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | ECW Hardcore Revolution Model SLUS-01045 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | Edición Oficial Española PlayStation Edición Coleccionistas Número 3 Model SCED-03239 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Edición Oficial Española PlayStation Especial Número 5 Model SCED-02851 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Egypt 1156 A.C. - L'Enigma della Tomba Reale Model SLES-01599 | 2000 | Canal+ Multimedia |
| Sony PlayStation CD | Egypt 1156 B.C. - Tomb of the Pharaoh Model SLES-01600 | 2000 | Canal+ Multimedia |
| Sony PlayStation CD | Egypte 1156 AV. J.-C. - L'Enigme de la Tombe Royale Model SLES-01597 | 2000 | Canal+ Multimedia |
| Sony PlayStation CD | Ehrgeiz - God Bless the Ring Model SLES-02111 | 2000 | Square Co., Ltd. Japan |
| Sony PlayStation CD |  Ehrgeiz - God Bless the Ring Model SLPS-02770 | 2000 | Square Co., Ltd. Japan |
| Sony PlayStation CD | Eidos Demo Disc Vol. 7 Model SLUS-90076 | 2000 | Eidos Interactive |
| Sony PlayStation CD | Elan Plus Model SLPS-02759 | 2000 | Visco Corp. Kyoto, Japan |
| Sony PlayStation CD | Elder Gate Taikenban Model SLPM-80560 | 2000 | Konami Co., Ltd. Japan |
| Sony PlayStation CD | Elder Gate Model SLPM-86494 | 2000 | Konami Corp. Japan |
| Sony PlayStation CD | Elder Gate Model SLPM-86494 | 2000 | Konami Co., Ltd. Japan |
| Sony PlayStation CD | En Busca del Valle Encantado - El Retorno al Gran Valle Model SLES-02985 | 2000 | TDK Recording Media Europe S.A. |
| Sony PlayStation CD | ESPN MLS Gamenight Model SLUS-01186 | 2000 | Konami of America CA, USA |
| Sony PlayStation CD | Esto Es Futbol 2 demo Model SCED-03205 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Esto Es Futbol 2 Model SCES-03076 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Eternal Eyes Model SLES-02270 | 2000 | SUNSOFT Kounan, Japan |
| Sony PlayStation CD | Eternal Eyes Model SLUS-01034 | 2000 | Crave Ent., Inc. |
| Sony PlayStation CD | Eve Zero Model SLPM-86478~80 | 2000 | NetVillage Japan |
| Sony PlayStation CD | Everybody's Golf 2 Model SCES-02146 | 2000 | Sony Computer Ent., Inc. SCEI Japan |
| Sony PlayStation CD | Evil Dead - Hail to the King Model SLUS-01072/01326 | 2000 | T-HQ, Inc. Toy HeadQuarters |
| Sony PlayStation CD | Evo's Space Adventures Model SLES-01871 | 2000 | Take-Two Interactive |
| Sony PlayStation CD | Exciting Pro Wres Model SLPS-02885 | 2000 | Yuke's Japan |
| Sony PlayStation CD | Expendable Model SLUS-01075 | 2000 | Infogrames Interactive, Inc. 329720 |
| Sony PlayStation CD | Extreme 500 Model SLES-02220 | 2000 | T-HQ, Inc. Toy HeadQuarters |
| Sony PlayStation CD | Élan Plus Model SLPS-02759 | 2000 | Visco Corp. Kyoto, Japan |
| Sony PlayStation CD | F1 2000 Model SLES-02722 | 2000 | EA Sports |
| Sony PlayStation CD | F1 2000 Model SLES-02723 | 2000 | EA Sports |
