| Sony PlayStation CD |  Chase the Express Model SCES-02815/12815 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD |  Chase the Express Model SCPS-10109~10 | 2000 | Sony Computer Ent., Inc. SCEI Japan |
| Sony PlayStation CD | Chess 2000 Model SLPS-02624 | 2000 | Unbalance Japan |
| Sony PlayStation CD | Chicken Run Model SLES-03188 | 2000 | Eidos Interactive |
| Sony PlayStation CD | Chicken Run Model SLUS-01304 | 2000 | Eidos Interactive |
| Sony PlayStation CD | Chiisana Oukoku Erutoria Model SLPS-02750 | 2000 | KSS Media Ent. Co. Japan |
| Sony PlayStation CD | Chinmoku no Kantai - The Silent Service Model SLPS-02788 | 2000 | Kodansha Japan |
| Sony PlayStation CD | Chou Nazoou Model SLPS-02123 | 2000 | Bandai Visual Co., Ltd. |
| Sony PlayStation CD | Chris Kamara's Street Soccer Model SLES-02948 | 2000 | Midas Int. Ent. |
| Sony PlayStation CD | Chrono Cross Model SLUS-01041/01080 | 2000 | Square Electronic Arts L.L.C. |
| Sony PlayStation CD |  Cinema Eikaiwa Series Dai-1-dan - Tengoku ni Ikenai Papa Model SLPM-86565~7 | 2000 | Success Japan |
| Sony PlayStation CD | Cinema Eikaiwa Series Dai-2-dan - Interceptor Model SLPM-86554~6 | 2000 | Success Japan |
| Sony PlayStation CD | Cinema Eikaiwa Series Dai-3-dan - Arashi ga Oka Model SLPM-86551~3 | 2000 | Success Japan |
| Sony PlayStation CD | Cinema Eikaiwa Series Dai-4-dan - Boy's Life Model SLPM-86568~71 | 2000 | Success Japan |
| Sony PlayStation CD | Cinema Eikaiwa Series Dai-5-dan - Zombie Model SLPM-86557~60 | 2000 | Success Japan |
| Sony PlayStation CD | Cinema Eikaiwa Series Dai-6-dan - Ai no Hate ni Model SLPM-86561~4 | 2000 | Success Japan |
| Sony PlayStation CD | City Bravo! Business-hen Model SLPS-02421 | 2000 | Altron Corp. |
| Sony PlayStation CD |  Codemasters Demo CD Model SLUS 90091 | 2000 | Codemasters Soft. Co., Ltd., The 015026 |
| Sony PlayStation CD | Codemasters Q3 2000 Demo Model SLED-03094 | 2000 | Codemasters Soft. Co., Ltd., The 015026 |
| Sony PlayStation CD | Cold Blood Model SCES-02151/SCES-12151 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Colin McRae - The Rally 02 Model SLPS-02878~9 | 2000 | Spike Japan |
| Sony PlayStation CD | Colin McRae Rally 2.0 Model SLES-02605 | 2000 | Codemasters Soft. Co., Ltd., The 015026 |
| Sony PlayStation CD | Colin McRae Rally 2.0 Model SLUS-01222 | 2000 | Sony Computer Ent. America SCEA CA, USA |
| Sony PlayStation CD | Colin McRae Rally Model SCUS-94474 | 2000 | Sony Computer Ent. America SCEA CA, USA |
| Sony PlayStation CD | Colony Wars - El Sol Rojo Model SCES-02624 | 2000 | Psygnosis, Ltd. |
| Sony PlayStation CD | Colony Wars - Red Sun Model SCES-01924 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Colony Wars - Red Sun Model SCES-02621 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Colony Wars - Red Sun Model SCES-02622 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Colony Wars - Red Sun Model SCES-02623 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Colony Wars III - Red Sun Model SLUS-00866 | 2000 | Midway Home Ent. |
| Sony PlayStation CD | Colorful Logic Model SLPS-02794 | 2000 | Altron Corp. |
| Sony PlayStation CD | Combi Mahjong Awase-uchi with Maboroshi Tsukiyo Characters Model SLPM-86515 | 2000 | GAPS, Inc. |
| Sony PlayStation CD | Contender 2 Model SLUS-01305 | 2000 | BAM! Ent. |
| Sony PlayStation CD | Cool Boarders 2001 demo Model SCUS-94625 | 2000 | Sony Computer Ent. America SCEA CA, USA |
| Sony PlayStation CD | Cool Boarders 2001 Model SCUS-94597 | 2000 | Sony Computer Ent. America SCEA CA, USA |
| Sony PlayStation CD | Cool Boarders 4 Model SCES-02283 | 2000 | 989 Studios CA, USA |
| Sony PlayStation CD | Cool Boarders 4 Model SLPS-02527 | 2000 | UEP Systems, Inc. |
| Sony PlayStation CD | Cosmowarrior Zero Model SLPM-86484 | 2000 | Taito Corp. Japan |
| Sony PlayStation CD | Countdown Vampires Model SLUS-00898/01199 | 2000 | Bandai America, Inc. 45557 |
| Sony PlayStation CD | Covert Ops - Nuclear Dawn Model SLUS-01151 | 2000 | Activision, Inc. Los Angeles, CA, USA 47875 |
