| Nintendo Super NES cart. |  SimCity Model SNSP-SC-NOE/SFRG | 1991 | Nintendo Co., Ltd. Japan |
| Nintendo Super NES cart. |  SimEarth - The Living Planet | 1993 | FCI Fujisankei Communications International |
| Nintendo Super NES cart. | Sink or Swim Model SNS-9J-USA | 1996 | Titus Gagny, France |
| Nintendo Super NES cart. | Sink or Swim Model SNSP-9J-EUR | 1996 | Titus Gagny, France |
| Nintendo Super NES cart. | Skuljagger - Revolt of the Westicans | 1992 | ASC Games |
| Nintendo Super NES cart. | Skyblazer Model SNS-LZ-USA | 1994 | Sony Imagesoft |
| Nintendo Super NES cart. | Skyblazer Model SNSP-LZ-FRG | 1994 | Sony Imagesoft |
| Nintendo Super NES cart. | SmartBall Model SNS-JB-USA | 1992 | Sony Imagesoft |
| Nintendo Super NES cart. | Smash Tennis | 1993 | Virgin Interactive Ent., Ltd. UK 013715 |
| Nintendo Super NES cart. | Snow White in Happily Ever After | 1994 | American Softworks Corp. |
| Nintendo Super NES cart. | Soccer Kid Model SNSP-YK-UKV | 1994 | Ocean Soft., Ltd. 13156 |
| Nintendo Super NES cart. | Soccer Shootout | 1994 | Capcom Co., Ltd. Japan |
| Nintendo Super NES cart. | Soldiers of Fortune | 1993 | Spectrum HoloByte |
| Nintendo Super NES cart. | Sonic Blast Man II Model SNS-2C-USA | 1994 | Taito America Corp. Elk Grove Village, IL, USA |
| Nintendo Super NES cart. | Sonic Blast Man Model SNS-SK-USA | 1993 | Taito America Corp. Elk Grove Village, IL, USA |
| Nintendo Super NES cart. | Sonic Blast Man Model SNSP-SK-EUR | 1993 | Taito Corp. Japan |
| Nintendo Super NES cart. | SOS | 1994 | Vic Tokai Japan |
| Nintendo Super NES cart. | Soul Blazer Model SNS-SO-USA | 1992 | Enix, Ltd. Japan |
| Nintendo Super NES cart. | Soul Blazer Model SNSP-SO-EUR | 1994 | Enix, Ltd. Japan |
| Nintendo Super NES cart. | Soul Blazer Model SNSP-SO-FRA/SFRA | 1994 | Enix, Ltd. Japan |
| Nintendo Super NES cart. | Soul Blazer Model SNSP-SO-NOE/SFRG | 1994 | Enix, Ltd. Japan |
| Nintendo Super NES cart. | Soul Edge Vs Samurai | 199? | DVS Electronics Co. |
| Nintendo Super NES cart. |  Sound Factory | 1993 | Nintendo Co., Ltd. Japan |
| Nintendo Super NES cart. | Space Ace Model SNS-5A-USA | 1994 | Absolute Ent., Inc. Midland Park, NJ, USA |
| Nintendo Super NES cart. | Space Ace Model SNSP-5A-EUR | 1994 | Empire Interactive Europe, Ltd. |
| Nintendo Super NES cart. | Space Football - One on One | 1992 | Triffix Ent., Inc. |
| Nintendo Super NES cart. | Space Invaders - The Original Game Model SNS-IC-USA | 1997 | Nintendo of America, Inc. USA 45496 |
| Nintendo Super NES cart. | Space Invaders - The Original Game Model SNSP-IC-AUS | 1997 | Nintendo Co., Ltd. Japan |
| Nintendo Super NES cart. | Space Invaders - The Original Game Model SNSP-IC-EUR | 1996 | Nintendo of Europe GmbH 45496 |
| Nintendo Super NES cart. | Space Megaforce Model SNS-AT-USA | 1992 | Toho Co., Ltd. Los Angeles, CA, USA |
| Nintendo Super NES cart. | Spanky's Quest Model SNS-HJ-USA | 1992 | Natsume, Inc. Burlingame, CA, USA |
| Nintendo Super NES cart. | Spanky's Quest Model SNSP-HJ-EUR | 1992 | Natsume, Inc. Japan |
| Nintendo Super NES cart. | Sparkster Model SNS-ASSE-USA | 1994 | Konami, Inc. USA |
| Nintendo Super NES cart. | Sparkster Model SNSP-ASSP-EUR | 1994 | Konami Co., Ltd. Japan |
| Nintendo Super NES cart. | Spawn Model SNS-A9WE-USA | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo Super NES cart. | Spawn Model SNSP-A9WP-EUR | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo Super NES cart. | Spectre Model SNS-7Q-USA | 1994 | CyberSoft |
| Nintendo Super NES cart. | Spectre Model SNSP-7Q-EUR | 1994 | CyberSoft |
| Nintendo Super NES cart. | Speed Racer in My Most Dangerous Adventures | 1994 | Accolade, Inc. San Jose, CA, USA 15605 |
| Nintendo Super NES cart. | Speedy Gonzales in Los Gatos Bandidos European Prototype | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
