| Arcade Video game |  Sky Jet | 2006 | Tecway Dev. Co., Ltd. |
| Slot Machine | Slotzilla | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Sneeki-Tiki | 2006 | IGT International Game Technologies Reno, NV, USA |
| Sony PSP UMD | Snoopy vs. the Red Baron | 2006 | NAMCO Bandai Games, Inc. Japan |
| Arcade Video game | Soccer 2006 | 2006 | IGS Co., Ltd. International Game System |
| Redemption mechanical game | Soccer King 2006 Model MA268C | 2006 | Progame Electronic Corp. Taiwan |
| Sony PlayStation 2 disc |  SOCOM - U.S. Navy SEALs - Combined Assault demo Model SCUS-97560 | 2006 | Sony Computer Ent. America SCEA CA, USA |
| Sony PlayStation 2 disc | SOCOM - U.S. Navy SEALs - Combined Assault Model SCUS-97545 | 2006 | Sony Computer Ent. America SCEA CA, USA |
| Sony PlayStation 2 disc |  SOCOM 3 - U.S. Navy SEALs Model SCES-53300 | 2006 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation 2 disc | SOCOM 3 - U.S. Navy SEALs Model SCKA 20064 | 2006 | Sony Computer Ent., Inc. SCEI Japan |
| Sony PSP UMD | SOCOM U.S. Navy SEALs - Fireteam Bravo 2 | 2006 | Sony Computer Ent. America SCEA CA, USA |
| Homelab soft. | Soko-Ban Hb | 2006 | Solti, Imre |
| Jupiter Ace cass. | SokoACE Hb | 2006 | Lopes, Ricardo Fernandes |
| Jupiter Ace cass. | SokoACE Map Editor Hb | 2006 | Lopes, Ricardo Fernandes |
| Sinclair ZX Spectrum+3 disk | Sokoban Hb | 2006 | Compiler |
| Sinclair ZX Spectrum cass. | Sokoban Hb | 2006 | Compiler |
| Sony PSP UMD | Sonic Rivals | 2006 | SEGA of America, Inc. San Francisco, CA, USA |
| Nintendo GBA cart. | Sonic the Hedgehog - Genesis Model AGB-BIJE-USA | 2006 | SEGA Corp. |
| Sony PlayStation 3 disc | Sonic the Hedgehog Model BLJM-60006 | 2006 | SEGA Corp. |
| PC/MS-Windows CD | Sono Hanabira ni Kuchizuke wo | 2006 | Fuguriya |
| Sega Beena cart. | Soreike! Anpanman Card de Tanoshiku ABC | 2006 | SEGA Toys |
| Sony PSP UMD | Sound Novel Portable Machi - Unmei no Kousaten - Tokubetsu-hen Model ULJM-05111 | 2006 | SEGA Corp. |
| Nintendo GBA cart. | Soundvoyager bit Generations Model AGB-BVGJ-JPN | 2006 | Nintendo Co., Ltd. Japan |
| PC/MS-Windows CD | Space Empires V | 2006 | Strategy First |
| Sony PSP UMD | Space Invaders Evolution | 2006 | Rising Star Games, Ltd. UK |
| Slot Machine | Space Race | 2006 | IGT International Game Technologies Reno, NV, USA |
| PC/MS-Windows CD | Space Rangers 2 - Dominators | 2006 | 1C Co. Russia |
| Medal video game | Special Race II | 2006 | Unknown Korea |
| Medal video game | Special Race Plus | 2006 | Unknown Korea |
| Sony PSP UMD | Spectral Souls - Resurrection of the Ethereal Empire Model ULUS-10076 | 2006 | NIS America, Inc. USA |
| Slot Machine | Speed Five | 2006 | Bally Wulff |
| MSX cart. | Speedjet Racers demo | 2006 | Karoshi Corp. |
| PC/MS-Windows CD | SpellForce 2 - Shadow Wars | 2006 | Aspyr |
| Mattel HyperScan CD | Spider-Man | 2006 | Mattel Electronics Mattel, Inc. |
| VTECH V.Smile cart. | Spider-Man & Freunde - Wettkampf im Space-Labor | 2006 | VTECH Video Technology, Ltd. |
| VTECH V.Smile cart. | Spider-Man & ses amis - Le Défi Du Docteur Ock | 2006 | VTECH Video Technology, Ltd. |
| Nintendo GBA cart. | Spider-Man - Battle for New York Model AGB-BC9E-USA | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| LeapFrog Leapster cart. | Spider-Man - L'Affaire Des Mots Mysteres | 2006 | LeapFrog |
| VTECH V.Smile cart. | Spider-Man y Amigos - La Aventura Del Doctor Octopus | 2006 | VTECH Video Technology, Ltd. |
| Slot Machine | Spirit of Africa | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
