| Slot Machine |  Serengeti | 2006 | IGT International Game Technologies Reno, NV, USA |
| PC/MS-Windows CD | Sexy Beach 3 | 2006 | Illusion Japan |
| Nintendo GBA cart. | Shamu's Deep Sea Adventures Model AGB-BBAP | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Magnavox Odyssey² cart. | Shark Hunter | 2006 | Classic Consoles Center |
| Slot Machine | Sheepload of Cash | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| PC/MS-Windows CD | Shikigami no Shiro III | 2006 | CyberFront Corp. Japan |
| Pachinko | Shima Kousaku | 2006 | Newgin Japan |
| Sega Beena cart. | Shimajirou no Eigo Activity Ehon - ABC Park de Asobou! | 2006 | SEGA Toys |
| Nintendo GBA cart. | Shin Chan contra los Muñecos de Shock Gahn | 2006 | Atari Interactive, Inc. |
| Pachinko | Shin Kage no Gundan | 2006 | Newgin Japan |
| Pachislot | Shin Mogu Mogu | 2006 | Net Corp. Japan |
| Pachislot | Shin Nihon Pro Wrestling Made Moga Pachislot Ki | 2006 | Heiwa Japan |
| Pachinko | Shin Ooedonikki | 2006 | Newgin Japan |
| Pachinko | Shin Rerere ni Omakase | 2006 | Daiichi Denshi |
| Sony PSP UMD | Shin Sangoku Musou - 2nd Evolution | 2006 | KOEI Co., Ltd. Japan |
| Sony PlayStation 2 disc | Shin Sangoku Musou 4 - Empires Model SLPM-66343 | 2006 | KOEI Co., Ltd. Japan |
| Sony PlayStation 2 disc | Shin Sangoku Musou 4 - Empires Model SLPM-6636~9 | 2006 | KOEI Co., Ltd. Japan |
| Slot Machine | Shinobi | 2006 | IGT International Game Technologies Reno, NV, USA |
| Pachislot | Shinzoukun | 2006 | Daiichi Denshi |
| PC/MS-Windows CD | Ship Simulator | 2006 | Lighthouse Interactive |
| Nintendo GBA cart. | Shonen Jump Naruto - Ninja Council 2 Model AGB-BN2E-USA | 2006 | D3 Publisher, Inc. |
| Nintendo GameCube disc | Shonen Jump's Naruto - Clash of Ninja Model DOL-GNRE-USA | 2006 | Tomy |
| Nintendo GBA cart. | Shonen Jump's Naruto - Ninja Council Model AGB-A7AE-USA | 2006 | D3 Publisher, Inc. |
| Nintendo GBA cart. | Shonen Jump's Shaman King - Master of Spirits 2 Model AGB-B2MP | 2006 | Konami Corp. Japan |
| Nintendo GBA cart. | Shonen Jump's Yu-Gi-Oh Ultimate Masters - World Championship Tournament 2006 Model AGB-BY6E-USA | 2006 | Konami Corp. Japan |
| Nintendo GBA cart. | Shonen Jump's Yu-Gi-Oh Ultimate Masters Edition - World Championship Tournament 2006 Model AGB-BY6P | 2006 | Konami Corp. Japan |
| Nintendo GBA cart. | Shonen Jump's Yu-Gi-Oh! GX - Duel Academy Model AGB-BYGE-USA | 2006 | Konami Corp. Japan |
| Nintendo GBA cart. | Shonen Jump's Yu-Gi-Oh! GX - Duel Academy Model AGB-BYGP | 2006 | Konami Corp. Japan |
| Slot Machine | Shop Til You Drop | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| Sky Gamestar game | Shrek - Double Trouble | 2006 | Sky Games |
| Sky Gamestar game | Shrek - Imperial Peril | 2006 | Sky Games |
| Nintendo GBA cart. | Shrek - Smash n' Crash Racing Model AGB-B4IE-USA | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Sony PSP UMD | Shrek Smash N' Crash Racing Model ULUS-10194 | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| PC/MS-Windows pack. | Sid Meier's Civilization III - Complete Model 3910 | 2006 | Steam Valve Corp. |
| PC/MS-Windows pack. | Sid Meier's Civilization IV Model 3900 | 2006 | Steam Valve Corp. |
| PC/MS-Windows pack. | Sid Meier's Pirates! Model 3920 | 2006 | Steam Valve Corp. |
| PC/MS-Windows CD | Sid Meier's Railroads! | 2006 | 2K Games, Inc. New York, NY, USA |
| Sony PSN: Shodai PS Archives pack. |  Silent Bomber Model NPJI-????? | 2006 | Bandai NAMCO Ent., Inc. |
| Slot Machine | Silver 7s | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Silver Knight | 2006 | IGT International Game Technologies Reno, NV, USA |
