| Slot Machine |  Scattereels | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Slot Machine | Scatterpillar | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Scattertainment | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| Commodore C64 disk | Schaikdash 14 Hb | 2006 | Schaik, Ron van |
| Sky Gamestar game | Scooby Doo - Where are You in Tomb it May Concern | 2006 | Sky Games |
| Sky Gamestar game | Scooby Doo Mysteries - The Case of the Creepy Cowboy | 2006 | Sky Games |
| LeapFrog Leapster cart. | Scooby-Doo! et les Nombres Fous! | 2006 | LeapFrog |
| PC/MS-Windows CD | Scrabble Interactive - 2007 Edition | 2006 | Ubisoft Ent. Montreuil sous Bois, France |
| Slot Machine | Scratch A Wild | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| Nintendo GBA cart. | Scurge - Hive Model AGB-BHVE-USA | 2006 | Orbital Media |
| Nintendo GBA cart. | Scurge - Hive Model AGB-BHVP | 2006 | SouthPeak Interactive, LLC |
| Nintendo Wii disc | SD Gundam Scad Hammers Model RVL-RSDJ-JPN | 2006 | Bandai Co., Ltd. Japan |
| Slot Machine | Sea of Gold | 2006 | Stargames, Ltd. Australia |
| Slot Machine | Sea Paradise | 2006 | Aruze Corp. Japan |
| Pachinko | Seacop Model FVW | 2006 | Sammy Corp. Japan |
| Pachinko | Seacop Model LVW | 2006 | Sammy Corp. Japan |
| Pachinko | Seacop Model SVW | 2006 | Sammy Corp. Japan |
| Slot Machine | Search for Atlantis | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Seaside Fries | 2006 | IGT International Game Technologies Reno, NV, USA |
| PC/MS-Windows CD | SeaWorld Adventure Parks Tycoon 2 | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| PC/MS-Windows CD | Secret Files - Tunguska | 2006 | Deep Silver, Inc. |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.22: Advanced Daisenryaku - Deutsch Dengeki Sakusen Model SLPM-62708 P | 2006 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.25: Gunstar Heroes Treasure Box Model SLPM-62712 P | 2006 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.26: Dynamite Deka Model SLPM-62717 P | 2006 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.27: Panzer Dragoon Model SLPM-62718 P | 2006 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.28: Tetris Collection Model SLPM-62746 P | 2006 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Classics Collection Model SLES-53461 | 2006 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Genesis Collection Model SLUS-21542 | 2006 | SEGA of America, Inc. San Francisco, CA, USA |
| Sony PSP UMD | Sega Genesis Collection Model ULUS-10192 | 2006 | SEGA of America, Inc. San Francisco, CA, USA |
| Arcade Video game | Sega Golf Club Version 2006 - Next Tours | 2006 | SEGA Corp. |
| Medal video game | Sega Network Casino Club | 2006 | SEGA Corp. |
| Pachinko | Seiryu Monogatari - Summer Memory | 2006 | Sanyo Japan |
| Medal video game | Sekai Bikkuri Tankentai | 2006 | Taito Corp. Japan |
| Commodore C64 disk | Sendydash Volume I Hb | 2006 | Liepa, Sendy |
| Microsoft XBOX 360 disc | Sengoku Musou 2 | 2006 | KOEI Co., Ltd. Japan |
| PC/MS-Windows DVD | Sengoku Rance Model ALS-0061 18 | 2006 | Alicesoft Japan |
| Microsoft XBOX 360 disc | Senko No Ronde Rev.X | 2006 | G.Rev |
| Sega NAOMI GD-ROM | Senko no Ronde SP Model GDL-0038 | 2006 | G.Rev |
| PC/MS-Windows CD | Sensible Soccer 2006 | 2006 | Codemasters Soft. Co., Ltd., The 015026 |
| Sony PlayStation 2 disc | Sensible Soccer 2006 Model SLES-53810 | 2006 | Codemasters Soft. Co., Ltd., The 015026 |
