| PC/MS-Windows CD |  Rogue Trooper | 2006 | Eidos Interactive |
| Redemption mechanical game | Rolling Tower - The Newest Style Pusher Machine | 2006 | Shoken Showa Giken |
| Slot Machine | Roman Empress | 2006 | Stargames, Ltd. Australia |
| Slot Machine | Romance in Venice | 2006 | IGT International Game Technologies Reno, NV, USA |
| PC/MS-Windows CD | Rome - Total War - Alexander | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Slot Machine | Rope 'Em In | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| Pachinko | Rose Tale Ultimate | 2006 | Toyomaru Japan |
| Slot Machine | Roulette | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Royal Fortuna | 2006 | F2 System Seoul, Korea |
| Slot Machine | Royal Horse | 2006 | Herb Home Technology Co., Ltd. China |
| Slot Machine | Royal Treatment | 2006 | IGT International Game Technologies Reno, NV, USA |
| PC/MS-Windows CD | RTL Ski Jumping 2006 | 2006 | RTL Playtainment |
| PC/MS-Windows CD | RTL Ski Jumping 2007 | 2006 | RTL Playtainment |
| PC/MS-Windows CD | RTL Winter Games 2007 | 2006 | RTL Playtainment |
| PC/MS-Windows CD | Rugby 06 | 2006 | EA Sports |
| Slot Machine | Ruins of Gold | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Pachislot | Rumble Roses | 2006 | KPE Konami Group Japan |
| Microsoft XBOX 360 disc | Rumble Roses XX | 2006 | Konami Digital Ent. Co., Ltd. |
| Slot Machine | Running Big Bear II | 2006 | Aruze Corp. Japan |
| MSX cart. | Running Naked in a Field of Flowers Hb | 2006 | Unknown |
| PC/MS-Windows CD | Rush for Berlin | 2006 | Deep Silver, Inc. |
| Sony PlayStation 2 disc |  Ryu ga Gotoku 2 Taikenban Model SLPM-61154 | 2006 | SEGA Corp. |
| Sony PlayStation 2 disc | Ryu ga Gotoku 2 Model SLPM-66602 | 2006 | SEGA Corp. |
| Sony PlayStation 2 disc |  Ryu ga Gotoku Model SLKA-25342 | 2006 | SEGA Corp. |
| Sony PlayStation 2 disc | Ryuuko no Ken - Ten Chi Jin NeoGeo Online Collection Vol.4 Model SLPS-25610 | 2006 | SNK Playmore Japan |
| Sony PlayStation 2 disc | Saint Seiya - The Hades Model SLES-54162 | 2006 | Bandai NAMCO Games, Inc. Japan |
| Microsoft XBOX 360 disc | Saints Row | 2006 | T-HQ, Inc. Toy HeadQuarters |
| Slot Machine | Samba Party | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Sony PlayStation 2 disc | Samurai Spirits - Tenkaichi Kenkakuden Model SLPS-25559 | 2006 | SNK Playmore Japan |
| Fruit Machine | Samurai Surprise | 2006 | Barcrest Games |
| Sony PlayStation 2 disc | Samurai Warriors 2 Model SLES-54340 | 2006 | KOEI Co., Ltd. Japan |
| Sony PlayStation 2 disc | Samurai Warriors 2 Model SLUS-21462 | 2006 | KOEI Corp. CA, USA |
| Dedicated Console | Samuri | 2006 | Hummer Team |
| Slot Machine | Sands of Marrakesh | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Arcade Video game | Sangokushi Taisen | 2006 | SEGA Corp. |
| Atari 7800 cart. | Santa Simon | 2006 | Unknown |
| Sky Digital interactive program | Save Our Sandy | 2006 | Sky Games |
| PC/MS-Windows CD | Scarface - The World is Yours | 2006 | Vivendi Universal Games, Inc. |
| Video Slot Machine | Scatter Magic III | 2006 | Aristocrat Leisure Industries Pty, Ltd. |
| Slot Machine | Scatterbrained | 2006 | IGT International Game Technologies Reno, NV, USA |
