| Nintendo GBA cart. |  Rayman - Raving Rabbids Model AGB-BQ3E-USA | 2006 | Ubisoft Ent. Montreuil sous Bois, France |
| Nintendo GBA cart. | Rayman - Raving Rabbids Model AGB-BQ3P | 2006 | Ubisoft Ent. Montreuil sous Bois, France |
| PC/MS-Windows CD | Rayman Raving Rabbids | 2006 | Ubisoft Ent. Montreuil sous Bois, France |
| Nintendo GBA cart. | Rebelstar - Tactical Command Model AGB-BRLP | 2006 | Atari Interactive, Inc. |
| Slot Machine | Red Hat | 2006 | Magistr Ukraine |
| Slot Machine | Red Hot N Rockin' | 2006 | Stargames, Ltd. Australia |
| Slot Machine | Red Hot N Spicy | 2006 | Stargames, Ltd. Australia |
| Fruit Machine | Red Racer | 2006 | Red Gaming, Ltd. Barcrest Group Birmingham, England |
| Slot Machine | Red White & Blue - Triple Star | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Reel Adventure | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| Slot Machine | Reel Gold | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Reel Hot Wins | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| Slot Machine | Reel Rally | 2006 | AGI Austrian Gaming Industries Novomatic Group |
| Sony PSP UMD | Rengoku II - Stairway to H.E.A.V.E.N. | 2006 | Konami Digital Ent. Co., Ltd. |
| PC/MS-Windows CD | Replay - Hasuksaeng | 2006 | Open Mind World Korea |
| GamePark GP2X Caanoo card | Replay 4 | 2006 | Open Mind World Korea |
| PC/MS-Windows CD | Replay 5 | 2006 | Open Mind World Korea |
| Nintendo GameCube disc | Resident Evil - 10th Anniversary Collection | 2006 | Capcom Ent., Inc. USA 13388 |
| Sony PlayStation 3 disc | Resistance - Fall of Man Model BCUS-98107 | 2006 | Sony Computer Ent. America SCEA CA, USA |
| Sony PlayStation 3 disc | Resistance - Jinrui Botsuraku no Hi Model BCJS-30003 | 2006 | Sony Computer Ent., Inc. SCEI Japan |
| Sinclair ZX Spectrum+3 disk | Revelados Hb | 2006 | Compiler |
| Nintendo GBA cart. | Rhythm Tengoku Model AGB-BRIJ-JPN | 2006 | Nintendo Co., Ltd. Japan |
| Slot Machine | Riches of Rome Life of Luxury Progressive | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| Sony PlayStation 3 disc | Ridge Racer 7 Model BLJS-10001 | 2006 | NAMCO, Ltd. Japan |
| Sony PlayStation 3 disc | Ridge Racer 7 Model BLUS-30001 | 2006 | NAMCO Bandai Games America, Inc. |
| Sony PSP UMD | Ridge Racers 2 | 2006 | NAMCO Bandai Games, Inc. Japan |
| PC/MS-Windows CD | Riding Star 2 | 2006 | Dtp Ent. AG |
| Slot Machine | Rinda no Neraiuchi | 2006 | IGT International Game Technologies Reno, NV, USA |
| PC/MS-Windows CD | Rise and Fall - Civilizations at War | 2006 | Midway Home Ent. |
| PC/MS-Windows CD | Rise of Legends | 2006 | Microsoft |
| Slot Machine | Road to Mandalay | 2006 | Konami Digital Ent. Co., Ltd. |
| Coin-op Misc. game | Robo Basho | 2006 | Robotic Amusements, Inc. |
| Arcade Video game | Rock Fever 5 | 2006 | IGS Co., Ltd. International Game System |
| Pachislot | Rock You Queen | 2006 | Eleco, Ltd. Aruze Group Japan |
| Nintendo GBA cart. | Rock'em Sock'em Robots Model AGB-BR7E-USA | 2006 | DSI Games |
| Nintendo GBA cart. | Rock'em Sock'em Robots Model AGB-BR7P | 2006 | Zoo Digital Publishing |
| Fruit Machine | Rocket Money | 2006 | Red Gaming, Ltd. Barcrest Group Birmingham, England |
| Slot Machine | Rockin' Riffs | 2006 | Stargames, Ltd. Australia |
| Sony PSP UMD | Rockman Rockman Model ULJM-05044 | 2006 | Capcom Co., Ltd. Japan |
| Slot Machine | Rocky & Bullwinkle & Friends | 2006 | Bally Gaming, Inc. Las Vegas, NV, USA |
