| Sony PlayStation CD |  Shougi Saikyou 2 Model SLPM-86069 | 1998 | Magical Co., Ltd. Japan |
| Sega Saturn CD | Shoujo Kakumei Utena Itsuka Kakumei Sareru Monogatari | 1998 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Shout & Shoot | 1998 | Art & Magic |
| Slot Machine | Shovel Master Gonzo | 1998 | Sigma Enterprises, Inc. Tokyo, Japan |
| Slot Machine | Show Down | 1998 | Mega |
| Sony PlayStation CD | Shura no Mon Model SLPS-01202 | 1998 | Kodansha Japan |
| Sony PlayStation CD | Side Pocket 3 - 3D Polygon Billiard Game Model SLPS-01079 | 1998 | Data East Corp. Japan |
| Video Slot Machine | Sigma Poker 2000 | 1998 | Sigma Game, Inc. |
| Sony PlayStation CD | Silent Möbius - Case: Titanic Model SLPS-01618 | 1998 | Gainax Japan |
| Sony PlayStation CD | Silent Möbius - Genei no Datenshi Model SLPS-01803 | 1998 | Bandai Co., Ltd. Japan |
| Sony PlayStation CD | Silhouette Mirage - Reprogrammed Hope Model SLPS-01449 | 1998 | ESP Ent. Soft. Publishing |
| PC/MS-Windows CD | Silkroad Hoshi no Shima no Monogatari | 1998 | Anjin Japan |
| Fruit Machine | Silver Ghost | 1998 | JPM International |
| Handheld game | Silver Surfer | 1998 | Tiger Electronic Toys, Inc. Orchard Mundelein, IL, USA |
| Video Slot Machine | Silver Wolf | 1998 | Aristocrat Leisure Industries Pty, Ltd. |
| Nintendo 64 cart. | Sim City 2000 Model NUS-NS2J | 1998 | Imagineer Co., Ltd. Japan |
| Sony PlayStation CD |  Sim City 2000 Model SLPS-91098 | 1998 | Artdink Corp. Japan |
| Sony PlayStation CD | Simple 1500 Series Vol. 1: The Mahjong Model SLPS-01631 | 1998 | Culture Publishers |
| Sony PlayStation CD | Simple 1500 Series Vol. 2: The Shougi Model SLPS-01632 | 1998 | Culture Publishers |
| Sony PlayStation CD | Simple 1500 Series Vol. 3: The Gomoku Narabe Model SLPS-01633 | 1998 | Culture Publishers |
| Sony PlayStation CD | Simple 1500 Series Vol. 4: The Reversi Model SLPS-01634 | 1998 | Culture Publishers |
| Sony PlayStation CD | Simple 1500 Series Vol. 5: The Igo Model SLPS-01683 | 1998 | Culture Publishers |
| Sony PlayStation CD | Simple 1500 Series Vol. 6: The Hanafuda Model SLPS-01684 | 1998 | Culture Publishers |
| Sony PlayStation CD | Simple 1500 Series Vol. 7: The Card Model SLPS-01685 | 1998 | Culture Publishers |
| Sony PlayStation CD | Simple 1500 Series Vol. 8: The Solitaire Model SLPS-01686 | 1998 | Culture Publishers |
| Slot Machine | Simply Wild | 1998 | WMS Gaming, Inc. Chicago, IL, USA |
| PC/MS-Windows CD | SimSafari | 1998 | Maxis Soft. Moraga, CA, USA |
| Sony PlayStation CD | Simulation RPG Tsukuru Model SLPS-00876 | 1998 | ASCII Corp. Japan |
| Sega Saturn CD | Simulation RPG Tsukuru Model T-2106G | 1998 | ASCII Corp. Japan |
| PC/MS-Windows CD | SiN | 1998 | Activision, Inc. Los Angeles, CA, USA 47875 |
| IBM PC/AT DOS pack. | Sint Nicolaas | 1998 | Wiering Soft., Mike |
| Arcade Video game | Sip Jang Saeng | 1998 | Buxsan Trading |
| Cambridge Z88 Cart. | Sir Lancelot Hb | 1998 | Unknown |
| Commodore Amiga 1200 disk | Sixth Sense Investigations | 1998 | Epic Marketing |
| Commodore Amiga CD | Sixth Sense Investigations | 1998 | Islona |
| Sony PlayStation CD | Ski Air Mix Model SLPS-01476 | 1998 | KID Kindle Imagine Develop |
| Arcade Video game | Ski Champ | 1998 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Skier's High | 1998 | Konami Co., Ltd. Japan |
| Video Slot Machine | Skill Cherry '97 | 1998 | Amcoe, Inc. USA |
| Arcade Video game | Skill Cherry '98 | 1998 | Amcoe, Inc. USA |
