| Apple II 5.25 disk |  Eamon 215: Treasure Island Hb | 1991 | Anderson, Margaret |
| IBM PC 5.25in. disk | Earl Weaver Baseball II Model 4404 | 1991 | Electronic Arts CA, USA 14633 |
| Sega Mega-CD | Earnest Evans Model T-32014 | 1991 | Wolf Team Japan |
| IGT Player's Edge Plus ROM kit | Earth Quake Model PS0086 | 1991 | IGT International Game Technologies Reno, NV, USA |
| Nintendo NES cart. |  Earthbound | 1991 | Nintendo Co., Ltd. Japan |
| Sinclair ZX Spectrum cass. | Eclipse | 1991 | Zenobi Soft. |
| Commodore Amiga 500 disk | Eco Phantoms | 1991 | Electronic Zoo |
| IBM PC/AT DOS 5.25in. disk | EcoQuest - The Search for Cetus | 1991 | Sierra On-Line, Inc. USA 20626 |
| IBM PC/AT DOS 3.5in. disk | EcoQuest - The Search for Cetus Model 85107 | 1991 | Sierra On-Line, Inc. USA 20626 |
| Amstrad CPC pack. |  Edd The Duck Model 878 | 1991 | EDOS Electronic Distribution of Software |
| Commodore Amiga 500 pack. | Edd The Duck Model 878 | 1991 | EDOS Electronic Distribution of Software |
| Atari ST pack. | Edd The Duck Model 878 | 1991 | EDOS Electronic Distribution of Software |
| Commodore C64 pack. | Edd The Duck Model 878 | 1991 | EDOS Electronic Distribution of Software |
| Commodore Amiga 500 disk | Edd the Duck! | 1991 | Impulze |
| NEC PC-Engine CD | Efera & Jiliora - The Emblem from Darkness Model BRCD1002 | 1991 | Brain Gray Co., Ltd. Japan |
| IBM PC DOS pack. | EGA Four | 1991 | Junod, John A. |
| IBM PC DOS pack. | EGA-Pyramid Sw | 1991 | Junod, John A. |
| IBM PC DOS pack. | Egawheel Ver. 16.0S Sw | 1991 | Mueller, Russel |
| Nintendo Famicom cart. | Egypt Model HUM-E9 | 1991 | Human Ent. Japan |
| Video Slot Machine | Eibise Model TS-001 | 1991 | Taito Corp. Japan |
| Video Slot Machine | Eibise Model TS-002 | 1991 | Taito Corp. Japan |
| SNK Neo-Geo AES cart. | Eightman Model NGH-025 | 1991 | SNK Corp. Shin Nihon Kikaku Japan |
| SNK Neo-Geo MVS cart. | Eightman Model NGM-025 | 1991 | SNK Corp. Shin Nihon Kikaku Japan |
| NEC PC-9801 Series 5.25in. disk | Eikan wa Kimi ni 2 - Koukou Yakyuu Zenkoku Taikai | 1991 | Artdink Corp. Japan |
| Fujitsu FM Towns CD | Eikan wa Kimi ni 2 - Koukou Yakyuu Zenkoku Taikai Model HMC-144 | 1991 | Artdink Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Eisei Meijin II Model RA607 | 1991 | Konami Co., Ltd. Japan |
| Amstrad CPC 464 disk | El Castillo Del Rey Certino Hb | 1991 | Unknown Spain |
| Arcade Video game | El Dorado | 1991 | Dyna Co., Ltd. Osaka, Japan |
| Sinclair ZX Spectrum+3 disk | El Gran Halcon | 1991 | Erbe Soft. Spain |
| Sinclair ZX Spectrum cass. | El Mundo Magico | 1991 | Aventuras Espanolas Spain |
| Sega Genesis cart. |  El Viento Model 49136 | 1991 | Renovation Products USA |
| Sega Mega Drive cart. | El Viento Model T-32063 | 1991 | Wolf Team Japan |
| IBM PC/AT DOS 5.25in. disk | Electro Body | 1991 | Xland Computer Games |
| Acorn Electron 3.5in. disk | Electron User Group #00 | 1991 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #00 | 1991 | EUG Electron User Group |
| IBM PC/AT DOS pack. | Electronic Aggravation Sw | 1991 | SimoneSystems Soft. |
| Chess board | Elektronika IM-01T | 1991 | Svetlana |
| Nintendo Game Boy Cart. | Elevator Action Model DMG-EA-NOE | 1991 | Taito Corp. Japan |
| Nintendo Game Boy Cart. | Elevator Action Model DMG-EA-USA | 1991 | Taito America Corp. Elk Grove Village, IL, USA |
| Nintendo Game Boy Cart. | Elevator Action Model DMG-EAA | 1991 | Taito Corp. Japan |
