| Nintendo Famicom cart. |  Erika to Satoru no Yume Bouken Model NAM-YB-4900 | 1988 | NAMCOT Japan |
| NEC PC-8801 Series disk | Erotic Magical Trip | 1988 | Unknown Japan |
| Commodore C64 disk | Escape and Evasion - Part 1 - Stalag 23 | 1988 | Guild, The |
| Sinclair ZX Spectrum cass. |  Escape from Khoshima | 1988 | Atlantis Soft. |
| Sinclair ZX Spectrum cass. | Escape from Magic | 1988 | Stewart, Eric |
| Pinball | Escape From the Lost World Model 0H05 | 1988 | Bally Midway Mfg. Co. Franklin Park, IL, USA |
| Sinclair ZX Spectrum cass. | Escape from the Shire | 1988 | D.N.D. Soft. |
| Amstrad CPC 464 disk | Espejos | 1988 | Dinamic Soft. Madrid, Spain |
| Commodore Amiga 500 disk | Espionage | 1988 | Grandslam Ent., Ltd. |
| Sinclair ZX Spectrum cass. | Espionage | 1988 | Grandslam Ent., Ltd. |
| Amstrad CPC cass. | Espionage | 1988 | Grandslam Ent., Ltd. |
| Sinclair ZX Spectrum+3 disk | Espionage | 1988 | Grandslam Ent., Ltd. |
| Amstrad CPC 464 disk | Espionage | 1988 | Grandslam Ent., Ltd. |
| Nintendo Famicom BASIC type-in | Esu-Dei-Ai | 1988 | Dempa Shinbunsha Japan |
| Sharp X1 5.25in. disk | Euphory | 1988 | System Sacom Corp. Japan |
| Commodore Amiga 500 disk | Euro Soccer '88 | 1988 | Ariolasoft Germany |
| Sinclair ZX Spectrum cass. | European 5-a-Side | 1988 | Silverbird Soft. 012439 |
| Commodore C64 cass. | European 5-a-Side | 1988 | Silverbird Soft. 012439 |
| Sinclair ZX Spectrum cass. | European Champions Model 9004 | 1988 | E&J Soft. |
| Atari ST disk | Eurosoccer '88 | 1988 | Grandslam Ent., Ltd. |
| Amstrad CPC type-in | Eva Strip Word | 1988 | Media Système Edition Gentilly, France |
| Sinclair ZX Spectrum cass. | Evaristo el Punky Model 1 STY 613 | 1988 | SPE Spain |
| Fujitsu FM-7 type-in | Eve & Adam Story | 1988 | Dempa Shinbunsha Japan |
| Sinclair ZX Spectrum cass. | Every Second Counts | 1988 | TV Games |
| Amstrad CPC cass. | Every Second Counts | 1988 | TV Games |
| Commodore C64 cass. | Every Second Counts | 1988 | TV Games |
| Amstrad CPC 464 disk | Every Second Counts | 1988 | TV Games |
| Amstrad CPC cass. | Everyone's A Wally - Meet The Gang Model 4SEA186 | 1988 | System 4 de Espana, S.A. Spain |
| Nintendo Famicom BASIC type-in | Evil Castle | 1988 | Dempa Shinbunsha Japan |
| Sinclair ZX Spectrum cass. | Evil Domain | 1988 | R&H Microtec |
| Commodore C64 disk | Evil Ridge, The | 1988 | Guild, The |
| MSX cart. | Examine Your Information 3 Model E086 | 1988 | Al Alamiah |
| Commodore Amiga 500 disk | Excalibur | 1988 | Kingsoft GmbH Germany |
| Pinball | Excalibur Model 715 | 1988 | Premier Technology Co. Bensenville, IL, USA |
| Chess board | Excel 68000 Mach II | 1988 | Fidelity Electronics |
| Chess board | Excel 68000 Mach III Master | 1988 | Fidelity Electronics |
| Arcade Video game | Excite League Model 317-0079 | 1988 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Nintendo Famicom disk | Exciting Soccer - Konami Cup Model KDS-ESC | 1988 | Konami Industry Co., Ltd. Japan |
| Acorn BBC/Electron cass. | Exile Model SUP 00194 | 1988 | Superior Soft. |
| Acorn BBC Micro B disk | Exile Model SUP 10192 | 1988 | Superior Soft. |
