| IBM PC 3.5in. disk |  Eliza P | 1988 | Danielson & Hashfield |
| Thomson TO disk | Elmo 0 | 1988 | AFL Association Francaise pour la Lecture France |
| Commodore C64 disk | Elon | 1988 | Markt & Technik |
| MSX 2 cart. | Elthlead Model MXNC22001 | 1988 | NCS Corp. Nippon Computer Systems Japan |
| Nintendo Famicom cart. | Elysion | 1988 | Tokyo Shoseki |
| IBM PC DOS pack. | EM Poker Solitaire Ver. 1.1 Sw | 1988 | Martins, Eduardo |
| Commodore Amiga 500 disk | Emerald Mine II | 1988 | Kingsoft GmbH Germany |
| Sinclair ZX Spectrum cass. | Emilio Butragueno Futbol | 1988 | Topo Soft. Spain |
| MSX cass. | Emilio Butragueno Futbol | 1988 | Topo Soft. Spain |
| Amstrad CPC 464 disk | Emilio Butragueno Futbol | 1988 | Erbe Soft. Spain |
| Sinclair ZX Spectrum+3 disk | Emilio Butragueno Futbol | 1988 | Topo Soft. Spain |
| Commodore C64 cass. | Emlyn Hughes International Soccer | 1988 | ASL Audiogenic Soft., Ltd. |
| Amstrad CPC 464 disk | Emlyn Hughes International Soccer Model ASL 52AM | 1988 | ASL Audiogenic Soft., Ltd. |
| Amstrad CPC cass. | Emlyn Hughes International Soccer Model ASL52AM | 1988 | ASL Audiogenic Soft., Ltd. |
| Pachinko | Empire | 1988 | Sanyo Japan |
| IBM PC 5.25in. disk | Empire - Wargame of the Century | 1988 | Interstel |
| Amstrad CPC 464 disk | Encyclopedia of War - Ancient Battles | 1988 | CCS Cases Computer Simulations, Ltd. London, England |
| VTECH PreComputer 1000 game | Encyclopedie | 1988 | VTECH Video Technology, Ltd. |
| Thomson MO5 cass. | Enduro Racer | 1988 | FIL France Image Logiciel |
| Amstrad CPC 464 disk | Enduro Racer + Super Sprint | 1988 | Proein Soft Line Spain |
| Sega Master System cart. |  Enduro Racer Model 5077 | 1988 | SEGA of America, Inc. San Francisco, CA, USA |
| Thomson TO disk | Enduro Racer Model DU 9179 | 1988 | FIL France Image Logiciel |
| Commodore C64 cass. | Endzone | 1988 | Alternative Soft., Ltd. |
| Sinclair ZX Spectrum cass. | Endzone - 88e Rosters + Program | 1988 | Sport-Sim |
| Sinclair ZX Spectrum cass. | Endzone - 88f Rosters | 1988 | Sport-Sim |
| Amstrad CPC cass. | Endzone Model AS179 | 1988 | Alternative Soft., Ltd. |
| Sharp MZ-700 type-in | Enei Game | 1988 | Dempa Shinbunsha Japan |
| Amstrad CPC cass. | Energy Warrior + Molecule Man Model IA 0236 | 1988 | MAD Mastertronic Added Dimension |
| MSX cart. | English | 1988 | Methali |
| Dart game | English Mark Darts 7000 Series | 1988 | Arachnid, Inc. Rockford, IL, USA |
| Amstrad CPC cass. | Enlightenment - Druid II Model 011583 | 1988 | Firebird Soft. UK 012439 |
| Amstrad CPC 464 disk | Enlightenment - Druid II Model 011590 | 1988 | Firebird Soft. UK 012439 |
| Commodore Amiga 500 disk | Enlightenment - Druid II Model 011712 | 1988 | Firebird Soft. UK 012439 |
| Sinclair ZX Spectrum cass. | Enter at Your Own Risk | 1988 | Teenware |
| Acorn Archimedes disk | Enthar Seven | 1988 | Robico Soft. |
| Atari 400/800 type-in | Entrepreneur Jungle | 1988 | ANTIC Publishing |
| Thomson TO disk | Equali | 1988 | FIL France Image Logiciel |
| Sinclair ZX Spectrum cass. | Era of Enchantment | 1988 | Sacred Scroll Soft. |
| Sinclair ZX Spectrum+3 disk | Erbe 88 | 1988 | Erbe Soft. Spain |
| Sinclair ZX Spectrum cass. | Erbe 88 | 1988 | Erbe Soft. Spain |
