| Slot Machine |  Sands of Gold | 2008 | IGT International Game Technologies Reno, NV, USA |
| Arcade Video game | Sangokushi Taisen 2 | 2008 | SEGA Corp. |
| Arcade Video game | Sangokushi Taisen 3 | 2008 | SEGA Corp. |
| Pachislot | Santa Festa | 2008 | Taiyo Co., Ltd. Japan |
| PC/MS-Windows CD | SAS - Secure Tomorrow | 2008 | City Interactive USA, Inc. |
| Coin-op Misc. game | SBBB - Super Big Baseball Board | 2008 | Atlus Co., Ltd. Japan |
| Microsoft XBOX 360 disc | SBK - Superbike World Championship | 2008 | Black Bean Games |
| Sony PSP UMD | SBK 08 - Superbike World Championship | 2008 | Black Bean Games |
| Sony PlayStation 3 disc | SBK 08 - Superbike World Championship Model BCAS-20065 | 2008 | Sony Computer Ent., Inc. SCEI Japan |
| PC/MS-Windows CD | SBK-08 - Superbike World Championship | 2008 | Black Bean Games |
| Slot Machine | Scary Slot | 2008 | Sirio Gaming San Cesareo, RM, Italy |
| Microsoft XBOX 360 disc | Scene It? Box Office Smash! | 2008 | Microsoft |
| LeapFrog Leapster cart. | Scholastic OutWit! | 2008 | LeapFrog |
| Apple Store pack. | Scoops | 2008 | Unknown |
| PC/MS-Windows CD | Score International Baja 1000 - The Official Game | 2008 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Apple Store pack. | Scrabble | 2008 | Unknown |
| Pachislot | Sea Roar | 2008 | Pioneer Co., Ltd. Japan |
| Pachinko | Sea Story Agnes Lam Edition | 2008 | Sanyo Japan |
| Pachislot | Sea Trad - Borabora Island | 2008 | Okazaki Sangyo Co., Ltd. Japan |
| Redemption game (mechanical) | Sea Wolf | 2008 | Coastal Amusements, Inc. Lakewood, NJ, USA |
| PC/MS-Windows pack. | Second Sight | 2008 | GOG sp. z o.o. |
| Sony PSP UMD | Secret Agent Clank | 2008 | Sony Computer Ent. America SCEA CA, USA |
| PC/MS-Windows CD | Secret Files 2 - Puritas Cordis | 2008 | Deep Silver, Inc. |
| PC/MS-Windows CD | Secret Service | 2008 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.32: Phantasy Star Complete Collection Model SLPM-62775 P | 2008 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.33: Fantasy Zone Complete Collection Model SLPM-62780 P | 2008 | SEGA Corp. |
| Medal game (video) | Sega Network Casino Club Ver. 2 | 2008 | SEGA Corp. |
| Arcade Video game | Sega Race TV | 2008 | SEGA Corp. |
| Microsoft XBOX 360 disc | SEGA Superstars Tennis | 2008 | SEGA of America, Inc. San Francisco, CA, USA |
| Sony PlayStation 3 disc | SEGA Superstars Tennis Model BLUS-30123 | 2008 | Sony Computer Ent. America SCEA CA, USA |
| Pachislot | Seira Teaser | 2008 | Ginza Japan |
| Sony PSN: Shodai PS Archives pack. |  Seirei Shokan - Princess of Darkness Model NPJI-????? | 2008 | Shoeisha Co., Ltd. Japan |
| Arcade Video game | Sengoku Basara X | 2008 | Capcom Co., Ltd. Japan |
| Pachinko | Sengoku Otome Model CRA | 2008 | Olympia Co., Ltd. Japan |
| Pachinko | Sengoku Otome Model SD | 2008 | Olympia Co., Ltd. Japan |
| Arcade Video game | Senior Nippon | 2008 | Taito Corp. Japan |
| Sony PlayStation 3 disc | Senjou no Valkyria Model BLJM-60063 | 2008 | SEGA Corp. |
| Arcade Video game | Senninha GP | 2008 | DiverBras |
| PC/MS-Windows pack. | Sensible Soccer 2006 | 2008 | GOG sp. z o.o. |
| PC/MS-Windows CD | Seven Kingdoms - Conquest | 2008 | CDV Soft. Ent. USA, Inc. |
