| APF Imagination cass. |  Star Trex | 1981 | Jones, G. R. |
| Apple II 5.25 disk | Starblaster | 1981 | Piccadilly Soft. |
| Exidy Sorcerer cass. | Starfighter | 1981 | Adventure International |
| Bally Astrocade type-in | Starfighter | 1981 | Fabris, Robert San Jose, CA, USA |
| Sinclair ZX-81 cass. | Starfighter + Pyramid + Artist Model 2 | 1981 | Greye Soft., J.K. UK |
| TRS-80 cass. | Starfighter Model 010-0120 | 1981 | Adventure International |
| TRS-80 disk | Starfighter Model 012-0120 | 1981 | Adventure International |
| Arcade Video game | Stargate | 1981 | Williams Electronics, Inc. Chicago, IL, USA |
| Apple II 5.25 disk | Starmines | 1981 | Softape |
| Apple II 5.25 disk | Starquest: Star Warrior | 1981 | Automated Simulations, Inc. |
| Atari 400/800 disk | Starquest: Star Warrior | 1981 | Automated Simulations, Inc. |
| Apple II/TRS-80 disk | Starquest: Star Warrior | 1981 | Automated Simulations, Inc. |
| Apple II 5.25 disk | Starship Commander | 1981 | Voyager Soft. |
| CP/M 8in. disk | Start Trek 3.2 | 1981 | DynaComp, Inc. |
| Sharp MZ-80B type-in | StarTrek | 1981 | Dempa Shinbunsha Japan |
| Atari 2600 cart. | Steeplechase Model 49-75126 | 1981 | Sears Chicago, IL, USA |
| TRS-80 cass. | Stellar Escort | 1981 | Big Five Soft. Van Nuys, CA, USA |
| PTC SOL-20 cass. | Stock Crash P | 1981 | Hopkins, Ralph |
| Slot Machine | Stock-Car | 1981 | Compu-Games A.S. Esbjerg, Denmark |
| Sinclair ZX-81 cass. | Stock-Market | 1981 | Video Soft., Inc. |
| Phillips Videopac cart. | Stone Sling Model 20 | 1981 | Philips Corp. |
| Texas instrument TI-99/4A cass. | Strange Odyssey Model PHT 6050 | 1981 | Texas Instruments |
| Bally Astrocade type-in | Strategic Air Command | 1981 | Fabris, Robert San Jose, CA, USA |
| TRS-80 type-in | Strategy Strike | 1981 | SoftSide Publications, Inc. |
| Apple II type-in | Strategy Strike | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 type-in | Strategy Strike P | 1981 | SoftSide Publications, Inc. |
| Arcade Video game | Strategy X | 1981 | Konami Industry Co., Ltd. Japan |
| Arcade Video game | Streaking | 1981 | Shoei Co., Ltd. |
| Saitek Sensor Chess mod. | Strong Play Module | 1981 | SciSys |
| Atari 400/800 disk | Stud Poker | 1981 | DynaComp, Inc. |
| Mattel Intellivision cart. | Sub Hunt Model 3408 | 1981 | Mattel Electronics Mattel, Inc. |
| Handheld game | Sub Wars Model 7-490 | 1981 | Tiger Electronic Toys, Inc. Orchard Mundelein, IL, USA |
| Sharp MZ-80K type-in | Submarine Game | 1981 | Kosaido Publishing |
| Sharp MZ-80K type-in | Submarine Game | 1981 | Seibundo Shinkosha Japan |
| Apple II 5.25 disk | Suicide | 1981 | Piccadilly Soft. |
| Atari 400/800 disk | Sumer 4000 B.C. | 1981 | Crystalware |
| Atari 400/800 disk | Sunday Golf Model 051-0101 | 1981 | Adventure International |
| Commodore VIC-20 cart. | Super Alien Model VIC-1906 | 1981 | Commodore, Ltd. |
| Exidy Sorcerer cass. | Super Asteroids | 1981 | System Soft. Australia |
| DECO cass. | Super Astro Fighter Model DT-109 | 1981 | Data East Corp. Japan |
