| Sharp MZ-80B type-in |  Space Invaders P | 1981 | Kohgaku-Sha Co.,Ltd. |
| Sinclair ZX-81 cass. | Space Invaders + Planetoids | 1981 | Macronics Systems |
| Sinclair ZX-81 cass. | Space Invaders + Space Rescue | 1981 | Macronics Systems |
| Sinclair ZX-81 cass. | Space Invaders 3K | 1981 | Macronics Systems |
| Nascom cass. | Space Invasion | 1981 | Level 9 Computing |
| Atari 400/800 type-in | Space Lander | 1981 | SoftSide Publications, Inc. |
| Acorn BBC/Electron cass. | Space Maze | 1981 | Micro Power, Ltd. |
| NEC PC-8001 type-in | Space Mouse | 1981 | Kohgaku-Sha Co.,Ltd. |
| Arcade Video game kit | Space Odyssey | 1981 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game |  Space Panic | 1981 | ADP-Automaten GmbH Germany |
| Sharp MZ-80K type-in | Space Panic | 1981 | ASCII Corp. Japan |
| Casio PV-1000 cart. | Space Panic Model GPA-111 | 1981 | Casio Computer Co., Ltd. |
| Heath/Zenith H8 soft. | Space Pirates | 1981 | Software Toolworks, The |
| Pinball | Space Poker | 1981 | LTD Sao Paulo, Brazil |
| Apple II 5.25 disk | Space Quarks | 1981 | Broderbund Soft., Inc. CA, USA 47956 |
| Arcade Video game | Space Rocks | 1981 | Estevez, J. Barcelona, Spain |
| TRS-80 cass. | Space Rocks | 1981 | Acorn Soft. Products, Inc. DC, USA |
| Arcade Video game | Space Seeker | 1981 | Taito Corp. Japan |
| Arcade Video game |  Space Shoot | 1981 | Atari, Inc. CA, USA |
| TRS-80 cass. | Space Shootout | 1981 | Displayed Video Ypsilanti, MI, USA |
| Mattel Intellivision cart. | Space Shuttle | 1981 | Mattel Electronics Mattel, Inc. |
| Mattel Intellivision cart. | Space Spartans Model 3416 | 1981 | Mattel Electronics Mattel, Inc. |
| Apple II 5.25 disk | Space Tilt | 1981 | DynaComp, Inc. |
| Arcade Video game | Space Train | 1981 | Armenia, Ltd. |
| Atari 400/800 cass. | Space Trap | 1981 | Artworx Soft. Co., Inc. |
| Atari 400/800 disk | Space Trap | 1981 | DynaComp, Inc. |
| Apple II 5.25 disk | Space Warrior | 1981 | Broderbund Soft., Inc. CA, USA 47956 |
| Sinclair ZX-81 cass. | Space-Game | 1981 | Video Soft., Inc. |
| Atari 2600 cart. | Spacechase Model AP2001 | 1981 | Apollo, Inc. Richardson, TX, USA |
| Atari 2600 cart. | Spacechase PAL Model AP-2001 | 1981 | Apollo, Inc. Richardson, TX, USA |
| Commodore PET type-in | Spacefire | 1981 | IPC Business Press, Ltd. |
| TRS-80 MC-10 cass. | Sparkle | 1981 | Unknown |
| Handheld game | Speak & Spell Compact | 1981 | Texas Instruments |
| Texas instrument TI-99/4A type-in | Speed Race | 1981 | EMAP East Midlands Allied Press |
| Commodore VIC-20 cart. | Speed/Bingo Math | 1981 | Commodore, Ltd. |
| Video Slot Machine | Spellbound | 1981 | ACE Nederlands |
| Apple II 5.25 disk | Spelling Bee Games | 1981 | Edu-Ware Services, Inc. |
| Radofin 1292 Advanced Programmable Video System cart. | Spider's Web | 1981 | Radofin Electronics Germany |
| Arcade Video game | Spiders | 1981 | Venture Line, Inc. Phoenix, AZ, USA |
| Redemption mechanical game | Spin Ball | 1981 | Komaya Co., Ltd. Japan |
