| Medal video game |  Sool Dog Ver.4 | 2005 | Andamiro Co., Ltd. |
| Medal video game | Sool Dog Ver.4 MultiNet | 2005 | Andamiro Co., Ltd. |
| Medal video game | Sool Dog Ver.4 Network | 2005 | Andamiro Co., Ltd. |
| Arcade Video game |  Sorcerian Legend | 2005 | Aruze Corp. Japan |
| Sega Pico game | Soreike! Anpanman - Anpanman no Hitori de Dekichatta! Model HPC-6146 | 2005 | SEGA Toys |
| Sega Beena cart. | Soreike! Anpanman Hajimete Kaketa yo! Oboeta yo! Hiragana Katakana - Gojuuon Board Kinou-tsuki | 2005 | SEGA Toys |
| Arcade Video game | Soul Calibur III Arcade Edition | 2005 | NAMCO, Ltd. Japan |
| MSX cart. | Space Crussader Hb | 2005 | Herrera, Gomez |
| Nintendo DS cart. | Space Invaders DS Model NTR-AIRJ-JPN | 2005 | Taito Corp. Japan |
| Sony PSP UMD | Space Invaders Pocket Model ULJM-05015 | 2005 | Taito Corp. Japan |
| Nintendo DS cart. | Space Invaders Revolution | 2005 | Rising Star Games, Ltd. UK |
| Nintendo DS cart. | Space Invaders Revolution Model NTR-AISE-USA | 2005 | Mastiff, LLC |
| Tabletop game | Space Invaders Model 402-A | 2005 | Excalibur Electronics, Inc. |
| Mobile game | Space Ray | 2005 | SK Telecom Korea |
| Nintendo GameCube disc | Spartan - Total Warrior | 2005 | SEGA of America, Inc. San Francisco, CA, USA |
| Nintendo GameCube disc | Spartan - Total Warrior Model DOL-GWAP-EUR | 2005 | SEGA Europe Ltd. |
| IGS PGM cart. | Spectral Vs Generation | 2005 | IGS Co., Ltd. International Game System |
| Arcade Video game | Speed Driver Evolution | 2005 | IGS Co., Ltd. International Game System |
| Slot Machine | Speed Run | 2005 | Bally Wulff |
| Medal video game | Speed Up | 2005 | Unknown Korea |
| Redemption mechanical game | Speeding Ticket | 2005 | Bugeye Technologies, Inc. Pacific, MO, USA |
| PC/MS-Windows CD | SpellForce - Shadow of the Phoenix | 2005 | JoWooD Productions AG |
| Arcade Video game | Spica Adventure | 2005 | Taito Corp. Japan |
| VTECH V.Smile cart. | Spider-Man & Freunde - Geheime Missionen | 2005 | VTECH Video Technology, Ltd. |
| VTECH V.Smile cart. |  Spider-Man & Friends - La Sfida del Dottor Ock | 2005 | Giochi Preziosi Italy |
| VTECH V.Smile cart. | Spider-Man & Friends - Missioni Segrete | 2005 | VTECH Video Technology, Ltd. |
| Sony PSP UMD | Spider-Man 2 | 2005 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| VTECH V.Smile cart. | Spider-Man en Vrienden - Geheime Missies | 2005 | VTECH Video Technology, Ltd. |
| VTECH V.Smile cart. | Spider-Man y Amigos - Misiones Secretas | 2005 | VTECH Video Technology, Ltd. |
| Pachinko | Spiderman Neo | 2005 | Takao Co., Ltd. Japan |
| Medal video game | Spin Rush | 2005 | Haentec Co., Ltd. Korea |
| Fruit Machine | Spin to Win | 2005 | QPS Interactive Novomatic Group |
| Slot Machine | Spindazzle | 2005 | IGT International Game Technologies Reno, NV, USA |
| Sony PlayStation 2 disc | SpinDrive Ping Pong Model SLES-52867 | 2005 | Empire Interactive Europe, Ltd. |
| PC/MS-Windows CD | Splinter Cell - Chaos Theory | 2005 | Ubisoft Ent. Montreuil sous Bois, France |
| Nikko DigiBLAST cart. | Sponge Bob Square Pants 1 | 2005 | Nikko Ent. B.V. |
| Jakks Pacific Nicktoons Game Key | Spongebob Sponge Pop + Snowball Showdown | 2005 | Jakks Pacific, Inc. |
| Redemption mechanical game | SpongeBob Squarepants - Jellyfishing | 2005 | Chicago Gaming Co. |
| Nintendo GameCube disc | SpongeBob SquarePants - Lights, Camera, Pants! | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo GBA cart. | SpongeBob SquarePants - Lights, Camera, Pants! Model AGB-BQQE-USA | 2005 | T-HQ, Inc. Toy HeadQuarters |
