| Sega Genesis cart. |  Earnest Evans Model 49176 | 1992 | Renovation Products USA |
| Sega Genesis cart. | Earthworm Jim 2 Model T-70446 | 1996 | Playmates Interactive Ent., Inc. La Mirada, CA, USA |
| Sega Genesis cart. | Earthworm Jim Model T-132036 | 1994 | Playmates Interactive Ent., Inc. La Mirada, CA, USA |
| Sega Genesis cart. | Ecco - The Tides of Time Model 1553 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Ecco Jr. Model 1554 | 1995 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. |  Ecco the Dolphin Model 1042 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | El Viento Model 49136 | 1991 | Renovation Products USA |
| Sega Genesis cart. | Elemental Master Model T-49236 | 1993 | Renovation Products USA |
| Sega Genesis cart. |  Elite | 1994 | Hybrid Technology |
| Sega Genesis cart. | ESPN Baseball Tonight Model T-93056 | 1995 | Sony Imagesoft |
| Sega Genesis cart. | ESPN National Hockey Night Model T-93176 | 1994 | Sony Imagesoft |
| Sega Genesis cart. | ESPN Speedworld Model T-93166 | 1994 | Sony Imagesoft |
| Sega Genesis cart. | ESPN Sunday Night NFL Model T-93046 | 1994 | Sony Imagesoft |
| Sega Genesis cart. | ESWAT - City Under Siege Model 1110 | 1990 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Eternal Champions Model 1145 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Evander Holyfield's 'Real Deal' Boxing | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Ex-Mutants Model 1074 | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Exile Model 49186 | 1991 | Renovation Products USA |
| Sega Genesis cart. | Exo Squad Model T-132026 | 1995 | Playmates Interactive Ent., Inc. La Mirada, CA, USA |
| Sega Genesis cart. | Exodus - Journey to the Promised Land Model ESG-1 | 1993 | Wisdom Tree, Inc. CA, USA |
| Sega Genesis cart. |  Eyra - The Crow Maiden demo | 2020 | Second Dimension |
| Sega Genesis cart. | F-117 Night Storm Model 7208 | 1993 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | F-15 Strike Eagle II Model T-104036 | 1993 | MicroProse, Ltd. Bristol, UK 015352 |
| Sega Genesis cart. | F1 Circus MD | 1991 | Nichibutsu USA Corp. USA |
| Sega Genesis cart. | F1 World Championship Edition | 1994 | Domark Group, Ltd. |
| Sega Genesis cart. | Family Feud Model T-83076 | 1993 | GameTek, Inc. Miami Beach, FL, USA 43948 |
| Sega Genesis cart. | Fantasia Model 1021 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Fatal Fury 2 Model T-103046 | 1994 | Takara USA Corp. New York, NY, USA 26483 |
| Sega Genesis cart. | Fatal Fury Model T-103016 | 1993 | Takara USA Corp. New York, NY, USA 26483 |
| Sega Genesis cart. | Fatal Labyrinth Model 1309 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Fatal Rewind Model 7092 | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Ferrari Grand Prix Challenge Model T-81016 | 1992 | Flying Edge |
| Sega Genesis cart. | Fido Dido Model T-33086 | 1994 | Kaneko USA, Ltd. IL, USA |
| Sega Genesis cart. | FIFA 97 - Gold Edition Model 7748 | 1996 | EA Sports |
| Sega Genesis cart. | FIFA International Soccer Model 7255 | 1993 | EA Sports |
| Sega Genesis cart. | FIFA Soccer 95 Model 7384 | 1994 | EA Sports |
| Sega Genesis cart. | FIFA Soccer 96 Model 7579 | 1995 | EA Sports |
| Sega Genesis cart. | Fighting Masters Model T-24056 | 1992 | TRECO USA |
| Sega Genesis cart. | Final Blow | 1990 | Taito America Corp. Elk Grove Village, IL, USA |
| Sega Genesis cart. | Final Zone Model T-49026 | 1990 | Renovation Products USA |
