| Sega Genesis cart. |  Black Jewel Reborn demo | 2022 | PSCD Games |
| Sega Genesis cart. |  Blades of Vengeance Model 7084 | 1993 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Blaster Master 2 Model T-15076 | 1993 | SUNSOFT Kounan, Japan |
| Sega Genesis cart. | Blockbuster World Video Game Championship II | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. |  Body Count | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. |  Bonanza Bros. Model 1124 P | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Bone Marrow demo | 2021 | PSCD Games |
| Sega Genesis cart. | Bone Marrow Rebirth demo | 2021 | PSCD Games |
| Sega Genesis cart. | Bonkers Model 1055 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Boogerman - A Pick and Flick Adventure Model T-125066 | 1994 | Interplay |
| Sega Genesis cart. | Boxing Legends of the Ring Model T-107026 | 1993 | Electro Brain Corp. |
| Sega Genesis cart. | Bram Stoker's Dracula Model T-93016 | 1993 | Sony Imagesoft |
| Sega Genesis cart. | Brave Battle Saga - The Legend of the Magic Warrior | 2017 | Piko Interactive LLC |
| Sega Genesis cart. | Brett Hull Hockey '95 Model 3409 | 1994 | Accolade, Inc. San Jose, CA, USA 15605 |
| Sega Genesis cart. | Brutal - Paws of Fury Model T-83136 | 1994 | GameTek, Inc. Miami Beach, FL, USA 43948 |
| Sega Genesis cart. | Bubba'n'Stix Model T-115026 | 1993 | Core Design, Ltd. |
| Sega Genesis cart. | Bubble and Squeak Model T-15096 | 1994 | SUNSOFT Kounan, Japan |
| Sega Genesis cart. | Bubsy II Model 3402 | 1994 | Accolade, Inc. San Jose, CA, USA 15605 |
| Sega Genesis cart. | Bubsy in Claws Encounters of the Furred Kind Model 3209 | 1993 | Accolade, Inc. San Jose, CA, USA 15605 |
| Sega Genesis cart. | Budokan - The Martial Spirit Model 7018 | 1990 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Bugs Bunny in Double Trouble Model 1840 | 1996 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Bulls versus Blazers and the NBA Playoffs Model 7202 | 1993 | EA Sports |
| Sega Genesis cart. | Bulls Vs Lakers and the NBA Playoffs Model 7099 | 1992 | EASN |
| Sega Genesis cart. | Burning Force Model T-14026 | 1990 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | Cadash Model T-11086 P | 1992 | Taito America Corp. Elk Grove Village, IL, USA |
| Sega Genesis cart. | Caesars Palace Model T-70146 | 1993 | Virgin Interactive Ent., Inc. USA 52145 |
| Sega Genesis cart. | Cal Ripken Jr. Baseball Model T-87046 | 1992 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| Sega Genesis cart. | Cal.50 - Caliber Fifty Model T-58026 | 1991 | Mentrix Soft., Inc. Torrance, CA, USA |
| Sega Genesis cart. | California Games Model 1207 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Canon - The Legend of the New Gods | 2019 | Piko Interactive LLC |
| Sega Genesis cart. | Captain America and the Avengers Model T-13056 | 1992 | Data East USA, Inc. |
| Sega Genesis cart. | Captain Planet and the Planeteers Model 1031 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Cascade | 2015 | Super Fighter Team |
| Sega Genesis cart. | Castle of Illusion Starring Mickey Mouse Model 1015 | 1990 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Castlevania - Bloodlines Model T-95076 | 1994 | Konami, Inc. USA |
| Sega Genesis cart. | Cave Story - Doukutsu Monogatari | 2020 | Studio Pixel |
| Sega Genesis cart. | Centurion - Defender of Rome Model 7025 | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Chakan - The Forever Man Model 1047 | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Champions - World Class Soccer Model T-81296 | 1993 | Flying Edge |
| Sega Genesis cart. | Championship Bowling Model T-58056 | 1993 | Mentrix Soft., Inc. Torrance, CA, USA |
