| Sega Genesis cart. |  Triple Score - 3 Games in 1 Model 1702 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Trouble Shooter | 1991 | Vic Tokai Japan |
| Sega Genesis cart. | Troy Aikman NFL Football | 1994 | Tradewest, Inc. Corsicana, TX, USA |
| Sega Genesis cart. |  Truxton | 1989 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Twin Cobra Model 1128 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. |  Twisted Flipper | 1992 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Two Crude Dudes | 1992 | Data East USA, Inc. |
| Sega Genesis cart. | Tyrants - Fight through Time | 1992 | Virgin Games, Ltd. UK 013715 |
| Sega Genesis cart. | Ultimate Mortal Kombat 3 Model T-97146 | 1996 | Williams Ent., Inc. |
| Sega Genesis cart. | Ultimate Qix Model 11046 | 1991 | Taito America Corp. Elk Grove Village, IL, USA |
| Sega Genesis cart. | Ultracore Hb | 2019 | Strictly Limited Games |
| Sega Genesis cart. | Uncharted Waters Model T-76026 | 1992 | KOEI Corp. CA, USA |
| Sega Genesis cart. | Universal Soldier | 1992 | Accolade, Inc. San Jose, CA, USA 15605 |
| Sega Genesis cart. | Unnecessary Roughness 95 | 1994 | Accolade, Inc. San Jose, CA, USA 15605 |
| Sega Genesis cart. | Urban Strike - The Sequel to Jungle Strike Model 7350 | 1994 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Uwol - Quest for Money Hb | 2010 | Mojon Twins, The |
| Sega Genesis cart. | Valis | 1991 | Renovation Products USA |
| Sega Genesis cart. | Valis III | 1991 | Renovation Products USA |
| Sega Genesis cart. | Vapor Trail Model T-49106 | 1991 | Renovation Products USA |
| Sega Genesis cart. | Vectorman 2 Model 1843 | 1996 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Vectorman Model 1577 | 1995 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Venom & Spider-Man - Separation Anxiety | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Viewpoint Model T-24096 P | 1994 | American Sammy Corp. Torrance, CA, USA |
| Sega Genesis cart. | Virtua Fighter 2 Model 1845 | 1996 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Virtua Racing Model 1229 P | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Virtual Bart Model T-81206 | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Virtual Pinball Model 7206 | 1994 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Wacky Races | 199? | Virgin Games Irvine, CA, USA 52145 |
| Sega Genesis cart. | Wacky Worlds - Creativity Studio Model 1713 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Wardner Model 58016 | 1991 | Mentrix Soft., Inc. Torrance, CA, USA |
| Sega Genesis cart. | Warlock Model T-81446 | 1994 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Warpspeed | 1993 | Accolade, Inc. San Jose, CA, USA 15605 |
| Sega Genesis cart. | Warrior of Rome II Model 22056 | 1992 | Micronet Co., Ltd. Japan |
| Sega Genesis cart. | Warrior of Rome Model 22026 | 1991 | Micronet Co., Ltd. Japan |
| Sega Genesis cart. | Warsong Model T-24046 | 1991 | TRECO USA |
| Sega Genesis cart. | Water Margin - The Tales of Clouds and Winds | 2016 | Piko Interactive LLC |
| Sega Genesis cart. | Wayne Gretzky and the NHLPA All-Stars Model T-48416 | 1995 | Time Warner Interactive |
| Sega Genesis cart. | Wayne's World Model T-100026 | 1993 | T-HQ Soft. |
| Sega Genesis cart. | Weaponlord Model T-14136 | 1995 | NAMCO, Ltd. Japan |
| Sega Genesis cart. | Wheel of Fortune Model T-83016 | 1992 | GameTek, Inc. Miami Beach, FL, USA 43948 |
