| Sega Genesis cart. |  Skitchin' Model 7205 | 1993 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Slaughter Sport | 1991 | Razorsoft, Inc. Oklahoma City, OK, USA |
| Sega Genesis cart. | Smart Mouse | 2016 | Piko Interactive LLC |
| Sega Genesis cart. | Socket Model T-23046 | 1994 | Vic Tokai Japan |
| Sega Genesis cart. | Sol-Deace Model T-49206 P | 1992 | Renovation Products USA |
| Sega Genesis cart. | Soldiers of Fortune Model T-124016 | 1993 | Spectrum HoloByte |
| Sega Genesis cart. |  Sonic & Knuckles Model 1563 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sonic 3D Blast Model 1844 | 1996 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sonic Classics Model 1190 | 1997 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sonic Spinball Model 1537 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sonic the Hedgehog 2 Model 1051 | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sonic the Hedgehog 3 Model 1079 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sonic the Hedgehog Model 1009-22 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sonic the Hedgehog Model 1009 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Sorcerer's Kingdom Model T-28076 | 1992 | TRECO USA |
| Sega Genesis cart. | Space Harrier II | 1989 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. |  Space Hero | 1992 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Space Invaders '91 | 1991 | Taito America Corp. Elk Grove Village, IL, USA |
| Sega Genesis cart. | Sparkster Model T-95166 | 1994 | Konami Co., Ltd. Japan |
| Sega Genesis cart. | Speedball 2 - Brutal Deluxe Model T-69026 | 1991 | Arena Ent. |
| Sega Genesis cart. | Spider-Man & Venom - Maximum Carnage Model T-81256 | 1994 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Spider-Man and X-Men - Arcade's Revenge Model T-81136 | 1994 | Flying Edge |
| Sega Genesis cart. | Spider-Man vs the Kingpin Model 1016 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Spider-Man Model T-81436 | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Spiritual Warfare | 1994 | Wisdom Tree, Inc. CA, USA |
| Sega Genesis cart. | Splatterhouse 2 Model T-14076 | 1992 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | Splatterhouse 3 Model T-14086 | 1993 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | Spot Goes to Hollywood Model T-81616 | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Star Control | 1991 | Ballistic |
| Sega Genesis cart. | Star Odyssey | 2011 | Super Fighter Team |
| Sega Genesis cart. | Star Odyssey | 1990 | Sage's Creation, Inc. |
| Sega Genesis cart. | Star Trek - Deep Space Nine - Crossroads of Time Model T-132076 | 1995 | Playmates Interactive Ent., Inc. La Mirada, CA, USA |
| Sega Genesis cart. | Star Trek - The Next Generation - Echoes from the Past Model 1313 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Stargate Model T-81396 | 1994 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Steel Empire | 1992 | Flying Edge |
| Sega Genesis cart. | Steel Talons Model 31763-04350 | 1992 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Stimpy's Invention Starring Starring Ren Hoëk & Stimpy Model 1068 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Stone Protectors | 1994 | Vic Tokai Japan |
| Sega Genesis cart. | Stormlord | 1990 | Razorsoft, Inc. Oklahoma City, OK, USA |
| Sega Genesis cart. | Street Fighter II' - Special Champion Edition Model T-12016 | 1993 | Capcom USA, Inc. Santa Clara, CA, USA 13388 |
