| Sega Genesis cart. |  Pirates! Gold Model T-104026 | 1993 | MicroProse, Ltd. Bristol, UK 015352 |
| Sega Genesis cart. | Pit-Fighter Model 301027 | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Pitfall - The Mayan Adventure Model T-130036 | 1994 | Activision, Inc. Los Angeles, CA, USA 47875 |
| Sega Genesis cart. | Pocahontas Model T-239036 | 1996 | Disney Interactive |
| Sega Genesis cart. | Populous Model 7016 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. |  Powerball Model T-14036 | 1991 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | PowerMonger Model 7105 | 1993 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Predator 2 Model T-81076 | 1992 | Arena Ent. |
| Sega Genesis cart. | Primal Rage Model T-48426 | 1995 | Time Warner Interactive |
| Sega Genesis cart. | Prime Time NFL Starring Deion Sanders | 1995 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Prince of Persia | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Pro Quarterback | 1992 | Tradewest, Inc. Corsicana, TX, USA |
| Sega Genesis cart. | Puggsy Model T-113016 | 1993 | Psygnosis, Ltd. |
| Sega Genesis cart. |  Putty Squad | 1992 | System 3 Soft., Ltd. |
| Sega Genesis cart. | Puzzli Hb | 2020 | Portabledev |
| Sega Genesis cart. | Quad Challenge Model T14056 | 1991 | NAMCO Hometek, Ltd. USA |
| Sega Genesis cart. | R.B.I. Baseball '93 Model 317630-3950 | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | R.B.I. Baseball '94 | 1994 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | R.B.I. Baseball '95 | 1995 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | R.B.I. Baseball 3 | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | R.B.I. Baseball 4 | 1992 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Race Drivin' Model T-48246 | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Radical Rex Model T-130026 | 1994 | Activision, Inc. Los Angeles, CA, USA 47875 |
| Sega Genesis cart. | Raiden Trad P | 1991 | Micronet Co., Ltd. Japan |
| Sega Genesis cart. | Rambo III | 1989 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Rampart | 1991 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Ranger-X Model 1076 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Rastan Saga II | 1990 | Taito America Corp. Elk Grove Village, IL, USA |
| Sega Genesis cart. | Red Zone Model T-48376 | 1994 | Time Warner Interactive |
| Sega Genesis cart. |  Reknum - Fantasy of Dreams demo | 2020 | PSCD Games |
| Sega Genesis cart. | Revolution X | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Richard Scarry's Busytown Model 1552 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Rings of Power Model 7024 | 1992 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Risk | 1994 | Parker Bros. Beverly, MA, USA |
| Sega Genesis cart. | Risky Woods Model 7156 | 1992 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Ristar Model 1555 | 1995 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Road Rash 3 - World Warriors Model 7347 | 1995 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Road Rash II Model 7146 | 1992 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Road Rash Model 7020 | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Road Riot 4WD | 1992 | Tengen, Inc. Milpilas, CA, USA |
