| Sega Mega-CD |  Dennin Aleste Model T-66014 | 1992 | Compile |
| Sega Mega-CD | Detonator Orgun Model T-28014 | 1992 | Hot-B Japan |
| Sega Mega-CD | Devastator Model T-32074 | 1993 | Wolf Team Japan |
| Sega Mega-CD | Double Switch Model 4419 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Double Switch Model G-6040 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Dracula Unleashed Model 4420 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD |  Dragon's Lair demo | 1993 | ReadySoft, Inc. Canada |
| Sega Mega-CD |  Dragon's Lair Model 061030 | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega-CD | Dragon's Lair Model 4436-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Dragon's Lair Model G-6035 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Dune Model T-70035-50 | 1993 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Mega-CD | Dungeon Explorer Model T-143025-50 | 1995 | Hudson Soft. Hudson Group Japan |
| Sega Mega-CD | Dungeon Master II - Skullkeep Model T-60085-50 | 1994 | JVC Musical Industries, Inc. |
| Sega Mega-CD | Dungeon Master II - Skullkeep Model T-60144 | 1994 | Victor Ent. Japan |
| Sega Mega-CD | Dynamic Country Club Model G-6017 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Earnest Evans Model T-32014 | 1991 | Wolf Team Japan |
| Sega Mega-CD | Earthworm Jim - Special Edition Model T-125045-50 | 1994 | Interplay |
| Sega Mega-CD | Ecco - The Tides of Time Model 4441-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Ecco the Dolphin CD Model G-6041 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Ecco the Dolphin Model 4408 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Egawa Suguru no Super League CD Model G-6019 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | ESPN Baseball Tonight Model T-93115-50 | 1994 | Sony Imagesoft |
| Sega Mega-CD | Eternal Champions - Challenge From the Dark Side Model 4427-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | F1 Circus CD Model T-71014 | 1994 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| Sega Mega-CD | Fahrenheit Model 4438-09 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Fahrenheit Model 4438-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Fahrenheit Model G-6043 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Fatal Fury Special demo | 1995 | JVC Musical Industries, Inc. |
| Sega Mega-CD | Fatal Fury Special Model T-60165-50 P | 1995 | JVC Musical Industries, Inc. |
| Sega Mega-CD | FIFA International Soccer - Championship Edition demo | 1994 | EA Sports |
| Sega Mega-CD | FIFA International Soccer - Championship Edition Model T-50055-50 | 1994 | EA Sports |
| Sega Mega-CD | Final Fight CD Model 4410 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Final Fight CD Model G-6013 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Flink Model T-113055-50 | 1994 | Psygnosis, Ltd. |
| Sega Mega-CD | Formula One World Championship - Beyond the Limit Model 4608 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Frog Feast demo | 2005 | Rastersoft |
| Sega Mega-CD | Gambler Jikochuushinha 2 - Gekitou! Tokyo Mahjongland-Hen Model T-45044 | 1992 | Game Arts Co., Ltd. Japan |
| Sega Mega-CD | Game no Kanzume Vol. 1 Model G-6032 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Game no Kanzume Vol. 2 Model G-6033 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega-CD | Garou Densetsu Special Model T-60214 | 1995 | JVC Musical Industries, Inc. |
