| Sega Mega Drive cart. |  Nigel Mansell's World Championship Racing Model T-95186-50 | 1993 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. |  Nightmare Circus Model 051070 | 1995 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Nikkan Sports Pro Yakyuu Van Model G-4522 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ninja Burai Densetsu Model G-4524 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Ninja Gaiden | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Nobunaga no Yabou - Bushou Fuuunroku Model T-76013 | 1991 | KOEI Co., Ltd. Japan |
| Sega Mega Drive cart. | Nobunaga no Yabou - Haouden Model T-76153 | 1994 | KOEI Co., Ltd. Japan |
| Sega Mega Drive cart. | Nobunaga no Yabou - Zen-Koku-Ban Model T-76033 | 1993 | KOEI Co., Ltd. Japan |
| Sega Mega Drive cart. | Nyuushi Chokuzen Check Nanmon Kimon Kiki Kaikai | 1995 | We Net |
| Sega Mega Drive cart. | Oh Mummy Hb | 2013 | 1985 Alternativo |
| Sega Mega Drive cart. | Olympic Gold | 1992 | US Gold, Ltd. Birmingham, England 13442 |
| Sega Mega Drive cart. | Olympic Gold | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | On Dal Jang Goon | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Osomatsu-kun Hachamecha Gekijou Model G-4005 | 1988 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Out of the Vortex | 199? | Unknown |
| Sega Mega Drive cart. | Out of this World | 1993 | Virgin Games, Ltd. UK 013715 |
| Sega Mega Drive cart. | Out Run Model 024240 | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Out Run Model 1125-50 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Out Run Model G-4052 P | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Outlander | 1992 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| Sega Mega Drive cart. | OutRun 2019 Model 1118-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | OutRun 2019 Model T-44033 | 1993 | SIMS Co., Ltd. Japan |
| Sega Mega Drive cart. | OutRunners Model G-4119 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Pac-Panic Model T-14116-50 | 1993 | NAMCO, Ltd. Japan |
| Sega Mega Drive cart. | Pachinko Kuunyan Model T-73013 | 1992 | Soft Vision Japan |
| Sega Mega Drive cart. | Panorama Cotton Model T-15103 | 1994 | SUNSOFT Kounan, Japan |
| Sega Mega Drive cart. | Paperboy Model 301029-0170 | 1992 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Paperboy Model T-48043 | 1992 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Paprium Model T-574116-50 Hb | 2020 | WaterMelon |
| Sega Mega Drive cart. | Paprium Model T-574120 Hb | 2020 | WaterMelon |
| Sega Mega Drive cart. | Party Quiz Mega Q Model G-4107 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Pebble Beach Golf Links Model 1231-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Pepenga PENGO Model G-4133 P | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Pete Sampras Tennis '96 | 1995 | Codemasters Soft. Co., Ltd., The 015026 |
| Sega Mega Drive cart. | PGA Tour Golf II Model EM20009 | 1993 | EA Sports |
| Sega Mega Drive cart. | Phantasy Star - Sennenki no Owari ni Model G-5524 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Phantasy Star Fukkokuban Model G-4534 P | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Phantasy Star II | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Phantasy Star II - Kaerazaru Toki no Owari ni Model G-5501 | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Phantasy Star II Model 048.170 | 1990 | Tec Toy Industria de Brinquedos S.A. Brazil |
