| Sharp X68000 Series 5.25in. disk |  Duel Fighter | 1996 | Take Soft |
| Sharp X68000 Series 5.25in. disk | Duel Fighter 2 | 1997 | Mugen Unagi Team |
| Sharp X68000 Series 5.25in. disk | Dungeon Master - Chaos Strikes Back | 1990 | Victor Musical Industries, Inc. Japan |
| Sharp X68000 Series 5.25in. disk | Dungeon Master Model X-5033~34 | 1990 | Victor Musical Industries, Inc. Japan |
| Sharp X68000 Series 5.25in. disk | Dungeon Seekers | 1990 | Haraiso |
| Sharp X68000 Series 5.25in. disk | Dynamic Fomesion Soccer | 1992 | MIX Japan |
| Sharp X68000 Series 5.25in. disk | Dynamite Duke | 1990 | Hertz Japan |
| Sharp X68000 Series 5.25in. disk | EEL Edit Elements | 1995 | CATsoft Japan |
| Sharp X68000 Series 5.25in. disk | EFF Erotic Fantasy Fable | 1994 | T&H Project |
| Sharp X68000 Series 5.25in. disk | Eikan wa Kimi ni - Koukou Yakyuu Zenkoku Taikai | 1990 | Artdink Corp. Japan |
| Sharp X68000 Series 5.25in. disk | Elf no Shoujou CG Puzzle | 19?? | Unknown Japan |
| Sharp X68000 Series 5.25in. disk | Elle 18 | 1991 | Elf Japan |
| Sharp X68000 Series 5.25in. disk | Elrin Da! Magazine Vol. 1 - Uchuu Tai Sakusen | 1993 | Elrin Da! |
| Sharp X68000 Series 5.25in. disk | Elrin Da! Magazine vol. 2 Quiz Uchuu Tai Sakusen | 1993 | Elrin Da! |
| Sharp X68000 Series 5.25in. disk | Emerald Densetsu | 1990 | System House Oh! Japan |
| Sharp X68000 Series 5.25in. disk | Emerald Dragon | 1990 | Glodia Co., Ltd. Japan |
| Sharp X68000 Series 5.25in. disk | Entführer | 1989 | Zenryutsu Japan |
| Sharp X68000 Series 5.25in. disk | Erion Quest | 1991 | Ankoku Baitai Soft. House |
| Sharp X68000 Series 5.25in. disk | Europa Sensen Model KN10221060 P | 1992 | KOEI Co., Ltd. Japan |
| Sharp X68000 Series 5.25in. disk | Evil Stone | 1989 | Zenryutsu Japan |
| Sharp X68000 Series 5.25in. disk | Evil Stone Kai | 1989 | Zenryutsu Japan |
| Sharp X68000 Series 5.25in. disk | Excitebike | 19?? | Unknown Japan |
| Sharp X68000 Series 5.25in. disk | eXOn | 1991 | Softec Japan |
| Sharp X68000 Series 5.25in. disk | Exterlien 18 | 1990 | DO Corp. Japan |
| Sharp X68000 Series 5.25in. disk | Ezoris | 1989 | KWP Japan |
| Sharp X68000 Series 5.25in. disk | Étoile Princesse | 1993 | EXACT Excellent Appreciation Create Team Japan |
| Sharp X68000 Series 5.25in. disk | F-1 Fastest Lap | 1991 | Michael Co. Japan |
| Sharp X68000 Series 5.25in. disk | F-15 Strike Eagle II | 1991 | MicroProse Japan K.K. |
| Sharp X68000 Series 5.25in. disk | F-15 Strike Eagle II - Sabaku no Arashi Sakusen Scenario Disk | 1992 | MicroProse Japan K.K. |
| Sharp X68000 Series 5.25in. disk | Fa-Mass | 1990 | VHS Japan |
| Sharp X68000 Series 5.25in. disk | Fairytale Kaizokuban | 1991 | Brother Kougyou Japan |
| Sharp X68000 Series 5.25in. disk | Fairytale Kaizokuban 2 | 1993 | Brother Kougyou Japan |
| Sharp X68000 Series 5.25in. disk | Famicom - Super Mario Bros. | 1985 | Nintendo Co., Ltd. Japan |
| Sharp X68000 Series 5.25in. disk | Fancy Qix | 1990 | AHS Japan |
| Sharp X68000 Series 5.25in. disk | Fantasy Shooting | 1989 | Michael Co. Japan |
| Sharp X68000 Series 5.25in. disk | Fantasy Zone Model DP-3205012 P | 1989 | Dempa Shinbunsha Japan |
| Sharp X68000 Series 5.25in. disk | Far Side Moon - Chikyuu Bouei-gun II | 1990 | Artdink Corp. Japan |
| Sharp X68000 Series 5.25in. disk | Farewell Disk | 1994 | Hayabusa Soft |
| Sharp X68000 Series 5.25in. disk | Févrie | 199? | Jeudi Japan |
| Sharp X68000 Series 5.25in. disk | Fifteens' 1 Hb | 19?? | Unknown |
