| Apple Macintosh disk |  Shadowgate Model 85319 | 1987 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| Apple Macintosh disk | Shanghai | 1986 | Activision, Inc. Mountain View, CA, USA 47875 |
| Apple Macintosh disk | Shanghai II - Dragon's Eye | 1991 | Activision, Inc. Menlo Park, CA, USA 47875 |
| Apple Macintosh disk | Shufflepuck Cafe Model 13355 | 1989 | Broderbund Soft., Inc. CA, USA 47956 |
| Apple Macintosh disk | Sierra Championship Boxing Model 11700 | 1985 | Sierra On-Line, Inc. USA 20626 |
| Apple Macintosh disk | Sierra's 3-D Helicopter Simulator Model 11740 | 1987 | Sierra On-Line, Inc. USA 20626 |
| Apple Macintosh disk | Silpheed - Super Dogfighter Model 11656 P | 1988 | Sierra On-Line, Inc. USA 20626 |
| Apple Macintosh disk | SimCity | 1989 | Maxis Soft. Moraga, CA, USA |
| Apple Macintosh disk | SimCity - Black & White ver. | 1989 | Infogrames Interactive, Inc. 329720 |
| Apple Macintosh disk | SimCity - Colour ver. | 1989 | Infogrames Interactive, Inc. 329720 |
| Apple Macintosh disk | SimCity Supreme | 1991 | Maxis Soft. Moraga, CA, USA |
| Apple Macintosh disk | SimEarth | 1990 | Maxis Soft. Moraga, CA, USA |
| Apple Macintosh disk | Skyfox Model 1120 | 1986 | Electronic Arts CA, USA 14633 |
| Apple Macintosh disk | Smash Hit Racquetball | 1986 | Primera Soft. |
| Apple Macintosh disk | Sorcerer Model IZ5-AP2 | 198? | Infocom, Inc. MA, USA 51051 |
| Apple Macintosh disk | Space Ace P | 199? | ReadySoft, Inc. Canada |
| Apple Macintosh disk | Space Ace II - Borf's Revenge | 1991 | ReadySoft, Inc. Canada |
| Apple Macintosh disk | Space Quest Chapter I - The Sarien Encounter Model 11290 | 1987 | Sierra On-Line, Inc. USA 20626 |
| Apple Macintosh disk | Space Quest II - Vohaul's Revenge Model 11292 | 198? | Sierra On-Line, Inc. USA 20626 |
| Apple Macintosh disk | Space Quest III - The Pirates of Pestulon Model 11294 | 1989 | Sierra On-Line, Inc. USA 20626 |
| Apple Macintosh disk | Spellbreaker Model IZ6-AP2 | 1985 | Infocom, Inc. MA, USA 51051 |
| Apple Macintosh disk | Speller Bee | 1985 | First Byte Soft. |
| Apple Macintosh disk | Squire - The Financial Planning Simulation | 1985 | Blue Chip Soft. |
| Apple Macintosh disk | Star Trek - The Kobayashi Alternative | 1985 | Simon & Schuster Interactive |
| Apple Macintosh disk | Starcross Model IS1-AP2 | 198? | Infocom, Inc. MA, USA 51051 |
| Apple Macintosh disk | Starflight 2 - Trade Routes of the Cloud Nebula Model 4368 P | 1991 | Electronic Arts CA, USA 14633 |
| Apple Macintosh disk | Starflight Model 3406 | 198? | Electronic Arts CA, USA 14633 |
| Apple Macintosh disk | Stationfall Model IS6-AP2 | 1987 | Infocom, Inc. MA, USA 51051 |
| Apple Macintosh disk | Strategic Conquest | 1985 | PBI Soft., Inc. Foster City, CA, USA |
| Apple Macintosh disk | Stratego | 1990 | Accolade, Inc. San Jose, CA, USA 15605 |
| Apple Macintosh disk | Strip Poker | 198? | Artworx Soft. Co., Inc. |
| Apple Macintosh disk | Strip Poker Data Disk #1 for Strip Poker Three: Morgan & Kathy 18 | 198? | Artworx Soft. Co., Inc. |
| Apple Macintosh disk | Strip Poker Data Disk #2 for Strip Poker Three: Jack & Samantha 18 | 198? | Artworx Soft. Co., Inc. |
| Apple Macintosh disk | Strip Poker Data Disk #3 for Strip Poker Three: Gina & Holly 18 | 198? | Artworx Soft. Co., Inc. |
| Apple Macintosh disk | Strip Poker Data Disk #4 for Strip Poker Three: Stacey & Desirée 18 | 198? | Artworx Soft. Co., Inc. |
| Apple Macintosh disk | Strip Poker Data Disk #5 for Strip Poker Three: Kelly & Maureen 18 | 198? | Artworx Soft. Co., Inc. |
| Apple Macintosh disk | Strip Poker Data Disk #6 for Strip Poker Three: Suzi & Melissa 18 | 198? | Artworx Soft. Co., Inc. |
| Apple Macintosh disk | Strip Poker Three 18 | 198? | Artworx Soft. Co., Inc. |
| Apple Macintosh disk | Sub Battle Simulator | 1987 | Epyx, Inc. Redwood City, CA, USA |
| Apple Macintosh disk | Suspect Model IM3-AP2 | 1984 | Infocom, Inc. MA, USA 51051 |
