| NEC PC-9801 Series 5.25in. disk |  Dynamite Girl | 199? | Unknown Japan |
| NEC PC-9801 Series 5.25in. disk | Dynamo | 1991 | Bio 100% Japan |
| NEC PC-9801 Series 5.25in. disk | E Tokyo Kyonyuu Story | 1992 | Apple Pie Japan |
| NEC PC-9801 Series 5.25in. disk | Early Kingdom | 1992 | C2 World |
| NEC PC-9801 Series 5.25in. disk | Echigoya - H-GO! Yeah! 18 | 1994 | Tengu Pro |
| NEC PC-9801 Series 5.25in. disk | Ecology Magic | 1992 | GAMU Japan |
| NEC PC-9801 Series 5.25in. disk | Eden no Kaori 18 | 1996 | Jast Japan |
| NEC PC-9801 Series 5.25in. disk | Edge | 1993 | TGL Technical Group Laboratory Japan |
| NEC PC-9801 Series 5.25in. disk | Eikan wa Kimi ni - Koukou Yakyuu Zenkoku Taikai | 1990 | Artdink Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Eikan wa Kimi ni 2 - Koukou Yakyuu Zenkoku Taikai | 1991 | Artdink Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Eikan wa Kimi ni 3 - Koukou Yakyuu Zenkoku Taikai | 1993 | Artdink Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Eimmy to Yobanaide 18 | 1995 | C's Ware |
| NEC PC-9801 Series 5.25in. disk |  Eimmy to Yobanaide demo | 1995 | C's Ware |
| NEC PC-9801 Series 5.25in. disk | Eisei Meijin II Model RA607 | 1991 | Konami Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Eiyuu Densetsu III - Mou Hitotsu no Eiyuu Tachi no Monogatari, Shiroki Majo Model NW10091010 | 1994 | Falcom Nihon Falcom Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Eiyuu Densetsu III - Shiroki Majo Renewal Model NW10091030 | 1994 | Falcom Nihon Falcom Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Eiyuu Densetsu IV - Akai Shizuku Model NW10091070 | 1996 | Falcom Nihon Falcom Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Eiyuu Densetsu Saga | 1984 | Micro Cabin Co. Japan |
| NEC PC-9801 Series 5.25in. disk | Eiyuu Shigan - Gal Act Heroism Model 41145 | 1994 | Micro Cabin Co. Japan |
| NEC PC-9801 Series 5.25in. disk | Ekispert | 1993 | Val Laboratory |
| NEC PC-9801 Series 5.25in. disk | Ekudorado - Kagami no Naka no Oukoku | 1997 | Black Package Japan |
| NEC PC-9801 Series 5.25in. disk | El Dominion | 1994 | Nihon Clary Business |
| NEC PC-9801 Series 5.25in. disk | El Dorado Denki Model E-G117 | 1985 | Enix, Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Ele | 199? | Unknown Japan |
| NEC PC-9801 Series 5.25in. disk | Ele Command | 199? | Elecom |
| NEC PC-9801 Series 5.25in. disk | Electric Device Marian - Kikai Jikake no Marian | 1994 | Janis Computer Soft., Inc. Japan |
| NEC PC-9801 Series 5.25in. disk | Elemental Ou 18 | 1994 | Apple Pie Japan |
| NEC PC-9801 Series 5.25in. disk | Elite Plus Model MP40371020 | 199? | MicroProse Japan K.K. |
| NEC PC-9801 Series 5.25in. disk | Elle 18 | 1991 | Elf Japan |
| NEC PC-9801 Series 5.25in. disk | Elm Knight - A Living Body Armor Demo | 1992 | Micro Cabin Co. Japan |
| NEC PC-9801 Series 5.25in. disk | Elm Knight - A Living Body Armor Model 22155 | 1992 | Micro Cabin Co. Japan |
| NEC PC-9801 Series 5.25in. disk | Elthlead Senshi Model NFNC21001 | 1989 | NCS Corp. Nippon Computer Systems Japan |
| NEC PC-9801 Series 5.25in. disk | Elves | 1992 | You-en-tai |
| NEC PC-9801 Series 5.25in. disk | Elvira - Mistress of the Dark | 1992 | Acclaim Japan |
| NEC PC-9801 Series 5.25in. disk | Elysion | 1986 | SystemSoft Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Emerald Densetsu | 1990 | System House Oh! Japan |
| NEC PC-9801 Series 5.25in. disk | Emerald Dragon | 1989 | Glodia Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Enchanter - Wakaki Madoushi no Shiren | 1993 | SystemSoft Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Endan Rekishi Emaki - Nukata no Ookimi | 1989 | Zenryutsu Japan |
| NEC PC-9801 Series 5.25in. disk | Endan Tokugawa Kouryuuki - Gorakuin | 1989 | Zenryutsu Japan |
