| NEC PC-9801 Series 5.25in. disk |  Dead of the Brain - Shiryou no Sakebi 18 | 1992 | IDES Japan |
| NEC PC-9801 Series 5.25in. disk | Dead of the Brain 2 | 1993 | IDES Japan |
| NEC PC-9801 Series 5.25in. disk | Death Bringer | 1988 | Telenet Japan |
| NEC PC-9801 Series 5.25in. disk | Debut | 1994 | Data West, Inc. Japan |
| NEC PC-9801 Series 5.25in. disk | Deep 18 | 1994 | Jast Japan |
| NEC PC-9801 Series 5.25in. disk | Deflektor | 1991 | BPS Bullet-Proof Soft. Japan |
| NEC PC-9801 Series 5.25in. disk | Deja Vu - A Nightmare Comes True Model PS-34 | 1991 | Pack-In-Video Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Deja Vu~2994. | 1994 | Unknown Japan |
| NEC PC-9801 Series 5.25in. disk | Delicious Lunchpack 18 | 1996 | Scoop Japan |
| NEC PC-9801 Series 5.25in. disk | Delphi no Shintaku Model KN10431010 | 1993 | KOEI Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Demon City 18 | 1993 | Cocktail Soft. Japan |
| NEC PC-9801 Series 5.25in. disk | Demon's Ring Model NFNW11002 | 1984 | Falcom Japan |
| NEC PC-9801 Series 5.25in. disk | Dengeki Division 18 | 1993 | Apple Pie Japan |
| NEC PC-9801 Series 5.25in. disk | Dengeki Nurse | 1992 | Cocktail Soft. Japan |
| NEC PC-9801 Series 5.25in. disk | Dengeki Nurse 2 - More Sexy | 1994 | Cocktail Soft. Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Gakuen - Cybernetic Hi-School | 1990 | Gainax Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Gakuen - Cybernetic Hi-School | 1989 | Gainax Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Gakuen 3 - Top wo Nerae! Model NHGX-14003 | 1990 | Gainax Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Gakuen 4 - Ape Hunter J | 1991 | Gainax Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Gakuen II - Highway Buster | 1989 | Gainax Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Gakuen Ver. 2.0 | 199? | Gainax Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Garou | 1993 | Apple Pie Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Sentai La Vie en Three | 1994 | Wendy Magazine |
| NEC PC-9801 Series 5.25in. disk | Dennou Shougi II - Eisei Meijin Model RA604 | 1990 | Konami Industry Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Shougi Model RA603 | 198? | Konami Industry Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Suikoden - Oogata Bouken Katsugeki Model NFHB24011 | 1987 | GAMU Japan |
| NEC PC-9801 Series 5.25in. disk | Dennou Tenshi - Digital Ange 18 | 1993 | Game Technopolis Japan |
| NEC PC-9801 Series 5.25in. disk | Denza | 199? | Unknown Japan |
| NEC PC-9801 Series 5.25in. disk | Derby Stallion | 1993 | ASCII Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Derby Stallion Expert | 1994 | ASCII Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | Derringer 18 | 1988 | Jast Japan |
| NEC PC-9801 Series 5.25in. disk | Desert Dragoon - Sabaku no Ryuukihei | 1993 | JHV Japan Home Video Japan |
| NEC PC-9801 Series 5.25in. disk | Desire - Haitoku no Rasen 18 | 1994 | C's Ware |
| NEC PC-9801 Series 5.25in. disk | Dessert | 1989 | Queensoft Japan |
| NEC PC-9801 Series 5.25in. disk | Destructor | 199? | HoeHoe Club Japan |
| NEC PC-9801 Series 5.25in. disk | Devil Chain 98 | 199? | Unknown Japan |
| NEC PC-9801 Series 5.25in. disk | Dezeni Land | 1984 | Hudson Soft. Hudson Group Japan |
| NEC PC-9801 Series 5.25in. disk | Diadrum | 1993 | Nihon Create Japan |
| NEC PC-9801 Series 5.25in. disk | Diamond Players | 1992 | Wolf Team Japan |
| NEC PC-9801 Series 5.25in. disk | Dies Irae | 1996 | Family Soft. Japan |
