| Nintendo Game Boy Color cart. |  Driver Model CGB-BDRP-EUU | 2000 | Infogrames Europe 546430 |
| Nintendo Game Boy Color cart. |  Dropzone Model DMG-AD4P-EUR | 1999 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo Game Boy Color cart. | Drymouth | 2000 | Demiforce |
| Nintendo Game Boy Color cart. | DT - Lords of Genomes Model DMG-BBDJ-JPN | 2001 | Media Factory Japan |
| Nintendo Game Boy Color cart. | Duke Nukem Model CGB-ADIE-USA | 1999 | GT Interactive Soft. Corp. NY, USA |
| Nintendo Game Boy Color cart. | Duke Nukem Model CGB-ADIP-EUR | 1999 | GT Interactive Soft. Corp. NY, USA |
| Nintendo Game Boy Color cart. | Dungeon Savior Model DMG-ADWJ-JPN | 2000 | J-Wing |
| Nintendo Game Boy Color cart. | DX Jinsei Game Model CGB-BZGJ-JPN | 2001 | Takara Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | DX Monopoly GB Model DMG-BMPJ-JPN | 2000 | Takara Co., Ltd. Japan |
| Nintendo Game Boy Color cart. |  DynaMike Prototype | 199? | Engine Soft. |
| Nintendo Game Boy Color cart. | E' Fighter HOT | 200? | Fiver Firm China |
| Nintendo Game Boy Color cart. | E.T. and the Cosmic Garden Model CGB-BEOE-USA | 2002 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | E.T. and the Cosmic Garden Model CGB-BEOP-EUR | 2002 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | E.T. The Extra Terrestrial - Digital Companion Model CGB-BETE-USA | 2001 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | E.T. The Extra Terrestrial - Escape from Planet Earth Model CGB-BERE-USA | 2001 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | E.T. The Extra Terrestrial - Escape from Planet Earth Model CGB-BERP-EUR | 2001 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | Earthworm Jim - Menace 2 the Galaxy Model DMG-AEBE-USA | 1999 | Crave Ent., Inc. |
| Nintendo Game Boy Color cart. | Earthworm Jim - Menace 2 the Galaxy Model DMG-AEBP-EUR | 1999 | Crave Ent., Inc. |
| Nintendo Game Boy Color cart. | ECW Hardcore Revolution Model CGB-BECE-USA | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo Game Boy Color cart. | ECW Hardcore Revolution Model CGB-BECP-EUR | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo Game Boy Color cart. | Elemental Tale - Jack no Daibouken - Daimaou no Gyakushuu Model DMG-AQJJ-JPN | 2000 | Imagineer Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | Elevator Action EX Model CGB-BEXJ-JPN | 2000 | Altron Corp. |
| Nintendo Game Boy Color cart. | Elevator Action EX Model CGB-BEXP-EUR | 2000 | TDK Recording Media Europe S.A. |
| Nintendo Game Boy Color cart. | Elie no Atelier GB Model DMG-A8EJ-JPN | 2000 | Imagineer Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | Elmo's 123s Model DMG-AE3E-USA | 1999 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | Elmo's 123s Model DMG-AE3P-EUR | 1999 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | Elmo's ABCs Model DMG-AEAE-USA | 1999 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | Emo Cheng 2 - Fengyun Pian | 200? | Li Cheng China |
| Nintendo Game Boy Color cart. | Emo Cheng DX | 200? | Sintax China |
| Nintendo Game Boy Color cart. | ESPN International Track & Field Model CGB-B3HE-USA | 2000 | Konami Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | ESPN National Hockey Night Model CGB-BT4E-USA | 2001 | Konami Corp. Japan |
| Nintendo Game Boy Color cart. | Estpolis Denki - Yomigaeru Densetsu Model CGB-BLCJ-JPN | 2001 | Taito Corp. Japan |
| Nintendo Game Boy Color cart. | European Super League | 2001 | Virgin Interactive Ent., Ltd. UK 013715 |
| Nintendo Game Boy Color cart. | Evel Knievel Model DMG-AEVE-USA | 1999 | Rockstar Games |
| Nintendo Game Boy Color cart. | Evel Knievel Model DMG-AEVP-EUR | 1999 | Take-Two Interactive |
| Nintendo Game Boy Color cart. | Extreme Ghostbusters Model CGB-BEBP-EUR | 2001 | LSP Light & Shadow Production |
| Nintendo Game Boy Color cart. | Extreme Sports with the Berenstain Bears Model CGB-BESE-USA | 2000 | Sound Source Interactive, Inc. |
| Nintendo Game Boy Color cart. | Extreme Sports with the Berenstain Bears Model CGB-BESP-EUR | 2000 | Sound Source Interactive, Inc. |
| Nintendo Game Boy Color cart. | F-1 World Grand Prix Model CGB-AFIP-EUR | 2000 | Video System Co., Ltd. Kyoto, Japan |
| Nintendo Game Boy Color cart. | F-18 Thunder Strike Model CGB-B18E-USA | 2000 | Majesco Sales, Inc. |
