| Sega Saturn CD |  Shinseiki Evangelion - Eva to Yukaina Nakamatachi | 1998 | Gainax Japan |
| Sega Saturn CD | Shinsetsu Samurai Spirits - Bushidoh Retsuden | 1997 | SNK Corp. Shin Nihon Kikaku Japan |
| Sega Saturn CD | Shinsetsu Yumemi Yakata - Tobira no Oku ni Darekaga... Model GS-9005 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shippuu Mahou Daisakusen - Kingdom Grandprix P | 1996 | GAGA Communications, Inc. Japan |
| Sega Saturn CD | Shiroki Majo - Mou Hitotsu no Eiyuu Densetsu | 1998 | Hudson Soft. Hudson Group Japan |
| Sega Saturn CD |  Shiroki Majo - Mou Hitotsu no Eiyuu Densetsu Taikenban | 1998 | Hudson Soft. Hudson Group Japan |
| Sega Saturn CD |  Shockwave Assault Model T-5005H-50 | 1996 | Electronic Arts CA, USA 14633 |
| Sega Saturn CD | Shockwave Assault Model T-5005H | 1996 | Electronic Arts CA, USA 14633 |
| Sega Saturn CD | Shougi Matsuri | 1995 | Seta Co., Ltd. Japan |
| Sega Saturn CD | Shoujo Kakumei Utena Itsuka Kakumei Sareru Monogatari | 1998 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shouryuu Sangoku Engi | 1996 | Imagineer Co., Ltd. Japan |
| Sega Saturn CD | Shunsai | 1996 | Naxat Soft. Japan |
| Sega Saturn CD | Shusse Mahjong Daisettai Model T-24902G | 1996 | King Records Co., Ltd. Japan |
| Sega Saturn CD | Shutsudou! Mini-skirt Police | 1997 | Sada Soft Genki |
| Sega Saturn CD | Sid Meier's Civilization - Shin Sekai Shichi Dai Bunmei Model T-2003G | 1997 | Asmik Co., Ltd. Japan |
| Sega Saturn CD | Side Pocket 2 - Densetsu no Hustler | 1995 | Data East Corp. Japan |
| Sega Saturn CD | Side Pocket 3 | 1997 | Data East Corp. Japan |
| Sega Saturn CD | Side Pocket 3 Sample | 1997 | Data East Corp. Japan |
| Sega Saturn CD | Silhouette Mirage Taikan CD-ROM Sousa Setsumei Model 610-6679 | 1997 | ESP Ent. Soft. Publishing |
| Sega Saturn CD | Silhouette Mirage Model T-32901G | 1997 | ESP Ent. Soft. Publishing |
| Sega Saturn CD | Sim City 2000 Model GS-9027 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Sim City 2000 Model MK81580-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Sim City 2000 Model T-12601H | 1995 | Maxis Soft. Moraga, CA, USA |
| Sega Saturn CD | Simulation RPG Tsukuru Model T-2106G | 1998 | ASCII Corp. Japan |
| Sega Saturn CD | Simulation Zoo | 1997 | Softbank Corp. Japan |
| Sega Saturn CD | Skeleton Warriors | 1996 | Playmates Interactive Ent., Inc. La Mirada, CA, USA |
| Sega Saturn CD | Skeleton Warriors | 1997 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Saturn CD | Skull Fang - Kuuga Gaiden Model T-1311G | 1997 | Data East Corp. Japan |
| Sega Saturn CD | Sky Target | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Sky Target | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Sky Target | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Slam 'n Jam '96 featuring Magic & Kareem Model T-15902H-50 | 1996 | Crystal Dynamics |
| Sega Saturn CD | Slam 'n Jam '96 featuring Magic & Kareem Model T-15902H | 1996 | Crystal Dynamics |
| Sega Saturn CD | Slam 'n Jam '96 featuring Magic & Kareem Model T-15905G | 1996 | BMG Victor |
| Sega Saturn CD | Slayers Royal 2 Model T-27907G | 1998 | Kadokawa Shoten Japan |
| Sega Saturn CD | Slayers Royal Model T-27903G | 1997 | Kadokawa Shoten Japan |
| Sega Saturn CD | Snatcher Model T-9508G | 1996 | Konami Co., Ltd. Japan |
| Sega Saturn CD | Sokkou Seitokai - Sonic Council | 1998 | Banpresto Japan |
| Sega Saturn CD | Sol Divide - Sword of Darkness Model T-14423G | 1998 | Atlus Co., Ltd. Japan |
| Sega Saturn CD | Solar Eclipse | 1995 | Crystal Dynamics |
