| Sega Saturn CD |  Sentimental Graffiti - First Window | 1997 | Nec InterChannel, Ltd. Japan |
| Sega Saturn CD | Sento Monogatari Sono I | 1995 | CRI CSK Research Institute Japan |
| Sega Saturn CD | Sexy Parodius Model T-9514G P | 1996 | Konami Co., Ltd. Japan |
| Sega Saturn CD | Shadows of the Tusk | 1998 | Hudson Soft. Hudson Group Japan |
| Sega Saturn CD | Shanghai - Banri no Choujou | 1995 | SUNSOFT Kounan, Japan |
| Sega Saturn CD | Shanghai - Great Moments Model T-1512G | 1996 | SUNSOFT Kounan, Japan |
| Sega Saturn CD | Shanghai - Triple Threat Model T-13001H | 1995 | Activision, Inc. Los Angeles, CA, USA 47875 |
| Sega Saturn CD | She'sn | 1998 | KID Kindle Imagine Develop |
| Sega Saturn CD | Shellshock | 1996 | Electronic Arts Victor, Inc. Japan |
| Sega Saturn CD | Shellshock | 1995 | US Gold, Ltd. Birmingham, England 13442 |
| Sega Saturn CD | Shellshock | 1996 | Core Design, Ltd. |
| Sega Saturn CD | Shichisei Toushin Guyferd - Crown Kaimetsu Sakusen | 1998 | Capcom Co., Ltd. Japan |
| Sega Saturn CD | Shichuu Suimei Pitagraph | 1996 | Datam Polystar |
| Sega Saturn CD | Shienryu Model T-29102G | 1997 | Warashi, Inc. |
| Sega Saturn CD | Shin Kaitei Gunkan - Koutetsu no Kodoku | 1997 | ASCII Corp. Japan |
| Sega Saturn CD | Shin Megami Tensei - Devil Summoner | 1995 | Atlus Co., Ltd. Japan |
| Sega Saturn CD | Shin Megami Tensei - Devil Summoner - Akuma Zensho | 1996 | Atlus Co., Ltd. Japan |
| Sega Saturn CD | Shin Megami Tensei - Devil Summoner Satakore | 1997 | Atlus Co., Ltd. Japan |
| Sega Saturn CD | Shin Megami Tensei - Devil Summoner Special Box | 1996 | Atlus Co., Ltd. Japan |
| Sega Saturn CD | Shin Ou Ken | 1997 | SNK Corp. Shin Nihon Kikaku Japan |
| Sega Saturn CD | Shin Shinobi Den | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shin Theme Park | 1997 | Electronic Arts Victor, Inc. Japan |
| Sega Saturn CD | Shingata Kururin Pa! Model T-24202G | 1996 | Sky Think System |
| Sega Saturn CD | Shining Force III - Scenario 1 - Outo no Kyoshin Model GS-9175 | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shining Force III - Scenario 2 - Nerawareta Miko Model GS-9188 | 1998 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shining Force III - Scenario 3 - Hyouheki no Jashinguu Model GS-9203 | 1998 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD |  Shining Force III Model 81383 | 1998 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shining Force III Model MK81383-50 | 1998 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shining the Holy Ark | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shining the Holy Ark | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shining the Holy Ark Model T-33101G | 1996 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shining Wisdom | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shining Wisdom | 1995 | Working Designs |
| Sega Saturn CD | Shining Wisdom | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shinobi Legions | 1995 | Vic Tokai Japan |
| Sega Saturn CD | Shinobi X | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shinpi no Sekai El-Hazard Shokai Tokuten Genteiban Model T-22202G | 1996 | Pioneer LDC, Inc. Japan |
| Sega Saturn CD | Shinrei Jusatsushi Taroumaru | 1997 | Time Warner Interactive |
| Sega Saturn CD | Shinseiki Evangelion | 1996 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Shinseiki Evangelion - 2nd Impression | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
