| Sega Saturn CD |  Puyo Puyo Sun Sega Saturn Collection Model T-6609G | 1998 | Compile |
| Sega Saturn CD | Puzzle Bobble 2X Model T-1106G | 1996 | Taito Corp. Japan |
| Sega Saturn CD | Puzzle Bobble 3 Model T-1109G | 1997 | Taito Corp. Japan |
| Sega Saturn CD | Pyon Pyon Kyaruru no Mahjong Hiyori | 1996 | Natsume, Inc. Japan |
| Sega Saturn CD | Quake | 1996 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Quake Model 81066 | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Quantum Gate I - Akumu no Joshou Model T-18502G | 1995 | GAGA Communications, Inc. Japan |
| Sega Saturn CD | Quarterback Attack Model T-16213H | 1995 | Digital Pictures |
| Sega Saturn CD | Quiz Nanairo Dreams - Nijiirochou no Kiseki | 1997 | Capcom Co., Ltd. Japan |
| Sega Saturn CD | QuoVadis | 1995 | Glams |
| Sega Saturn CD | QuoVadis 2 - Wakusei Kyoushuu Ovan Rei | 1997 | Glams |
| Sega Saturn CD | R?MJ - The Mystery Hospital | 1997 | Bandai Co., Ltd. Japan |
| Sega Saturn CD | Rabbit | 1997 | Electronic Arts Victor, Inc. Japan |
| Sega Saturn CD | Race Drivin' Model T-4802G | 1995 | Time Warner Interactive |
| Sega Saturn CD | Radiant Silvergun Model T-32902G | 1998 | ESP Ent. Soft. Publishing |
| Sega Saturn CD | Rampage - World Tour Model T-25416H-50 | 1996 | GT Interactive Soft. Corp. NY, USA |
| Sega Saturn CD | Rampage - World Tour Model T-9708H | 1997 | Williams Ent., Inc. |
| Sega Saturn CD | Rampo | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Rayman | 1995 | UBI Soft Creteil, France 307211 |
| Sega Saturn CD | Rayman Yo! Electoon wo Sukue! | 1995 | UBI Soft Creteil, France 307211 |
| Sega Saturn CD | Rayman Model T-17701H | 1995 | UBI Soft Creteil, France 307211 |
| Sega Saturn CD | Real Bout Garou Densetsu Best Collection Model T-3124G | 1998 | SNK Corp. Shin Nihon Kikaku Japan |
| Sega Saturn CD | Real Bout Garou Densetsu Special Model T-3117G | 1997 | SNK Corp. Shin Nihon Kikaku Japan |
| Sega Saturn CD | Real Bout Garou Densetsu Special Model T-3119G | 1997 | SNK Corp. Shin Nihon Kikaku Japan |
| Sega Saturn CD | Real Bout Garou Densetsu Model T-3105G | 1996 | SNK Corp. Shin Nihon Kikaku Japan |
| Sega Saturn CD | Real Mahjong Adventure - Umi-he - Summer Waltz | 1998 | Seta Co., Ltd. Japan |
| Sega Saturn CD | Real Mahjong Adventure - Umi-He - Summer Waltz - P's Club Genteiban | 1998 | Seta Co., Ltd. Japan |
| Sega Saturn CD | Real Sound - Kaze no Regret | 1997 | Warp |
| Sega Saturn CD | Rebellion | 199? | Unknown USA |
| Sega Saturn CD | Refrain Love - Anatani Aitai Model SLPS-00753 | 1997 | Riverhill Soft. Japan |
| Sega Saturn CD |  Resident Evil Model MK81092-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Resident Evil Model T-1221H | 1997 | Capcom Co., Ltd. Japan |
| Sega Saturn CD | Resurrection - Rise 2 | 1996 | Acclaim Japan |
| Sega Saturn CD | Resurrection - Rise 2 | 1996 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Saturn CD | Resurrection - Rise 2 Model T-8114H | 1996 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Saturn CD | Return Fire Model T-4805H | 1997 | Williams Ent., Inc. |
| Sega Saturn CD | Return to Zork | 1996 | Bandai Visual Co., Ltd. |
| Sega Saturn CD | Revolution X - Music is the Weapon | 1996 | Acclaim Japan |
| Sega Saturn CD | Revolution X featuring Aerosmith | 1996 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Saturn CD | Revolution X featuring Aerosmith Model T-8107H | 1996 | Acclaim Ent., Inc. Glen Cove, NY, USA |
