| Sega Saturn CD |  Dragon Force Model GS-9145 | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD |  Dragon Force Model MK81382-50 | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Dragon Force Model T-12703H | 1996 | Working Designs |
| Sega Saturn CD |  Dragon Master Silk | 1997 | Datam Polystar |
| Sega Saturn CD | Dragon's Dream | 199? | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | DragonHeart - Fire & Steel | 1997 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Saturn CD | DragonHeart - Fire & Steel Model T-8117H | 1996 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Saturn CD | Dream Generation - Koi ka? Shigoto ka!? Model T-2511G | 1998 | NCS Corp. Nippon Computer Systems Japan |
| Sega Saturn CD | Dream Square Hinagata Akiko Model T-3002G | 1997 | Video System Co., Ltd. Kyoto, Japan |
| Sega Saturn CD | Drift King Shutokou Battle '97 - Tsuchiya Keiichi & Bandou Masaaki | 1997 | Imagineer Co., Ltd. Japan |
| Sega Saturn CD | Drift King Shutokou Battle '97 - Tsuchiya Keiichi & Bandou Masaaki Mihonhin | 1997 | Imagineer Co., Ltd. Japan |
| Sega Saturn CD | Druid - Yamie no Tsuisekisha Model T-7670G | 1998 | KOEI Co., Ltd. Japan |
| Sega Saturn CD | Duke Nukem 3D | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Duke Nukem 3D Model 81071 | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Dungeon Master Nexus | 1998 | Victor Interactive Soft., Inc. |
| Sega Saturn CD | Dungeon's & Dragons - Tower of Doom Dungeons & Dragons Collection Disc 1 | 1999 | Capcom Co., Ltd. Japan |
| Sega Saturn CD | Dungeons & Dragons - Shadow over Mystara Dungeons & Dragons Collection Disc 2 | 1999 | Capcom Co., Ltd. Japan |
| Sega Saturn CD | DX Jinsei Game | 1995 | Takara Co., Ltd. Japan |
| Sega Saturn CD | DX Jinsei Game II | 1997 | Takara Co., Ltd. Japan |
| Sega Saturn CD | DX Jinsei Game Satakore | 1997 | Takara Co., Ltd. Japan |
| Sega Saturn CD | DX Nippon Tokkyuu Ryokou Game - Let's Travel in Japan | 1996 | Takara Co., Ltd. Japan |
| Sega Saturn CD | Dynamite Deka Model GS-9122 | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Earthworm Jim 2 Model T-10304G | 1996 | Takara Co., Ltd. Japan |
| Sega Saturn CD | Earthworm Jim 2 Model T-13203H | 1996 | Playmates Interactive Ent., Inc. La Mirada, CA, USA |
| Sega Saturn CD | Earthworm Jim 2 Model T-7019H-50 | 1996 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Saturn CD | Eberouge Special - Koi to Mahou no Gakuen Seikatsu | 1998 | Takara Co., Ltd. Japan |
| Sega Saturn CD | Eberouge Model T-10309G P | 1997 | Takara Co., Ltd. Japan |
| Sega Saturn CD | Eisei Meijin | 1995 | Konami Co., Ltd. Japan |
| Sega Saturn CD | Eisei Meijin II Model T-9516G | 1996 | Konami Co., Ltd. Japan |
| Sega Saturn CD | Eiyuu Shigan - Gal Act Heroism | 1998 | Micro Cabin Co. Japan |
| Sega Saturn CD | Elevator Action Returns Model T-19903G | 1997 | Ving Japan |
| Sega Saturn CD | Elf wo Karu Monotachi - Hanafuda-hen Model T-16606G | 1997 | Altron Corp. |
| Sega Saturn CD | Elf wo Karu Monotachi II Model T-16610G | 1998 | Altron Corp. |
| Sega Saturn CD | Elf wo Karu Monotachi Model T-16605G | 1997 | Altron Corp. |
| Sega Saturn CD | EMIT Vol. 1 - Toki no Maigo Model T-7602G | 1995 | KOEI Co., Ltd. Japan |
| Sega Saturn CD | EMIT Vol. 2 - Inochigake no Tabi Model T-7603G | 1995 | KOEI Co., Ltd. Japan |
| Sega Saturn CD | EMIT Vol. 3 - Watashi ni Sayonara o | 1995 | KOEI Co., Ltd. Japan |
| Sega Saturn CD | Enemy Zero | 1996 | Warp |
| Sega Saturn CD | Enemy Zero | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Saturn CD | Enemy Zero Model 81076 | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
