| Nintendo Famicom cart. |  Akira Model TFC-AK-6800 | 1988 | Taito Corp. Japan |
| Nintendo Famicom cart. | Alien Syndrome Model SAN-AZ P | 1988 | SUNSOFT Kounan, Japan |
| Nintendo Famicom cart. | America Daitouryou Senkyo Model HCT-AQ/002 | 1988 | HECT Hector Japan |
| Nintendo Famicom cart. | Arkanoid II Model TFC-ANII-5900 P | 1988 | Taito Corp. Japan |
| Nintendo Famicom cart. | Ballblazer Model R55V5911 (PNF-BZ) | 1988 | Pony Canyon, Inc. Japan |
| Nintendo Famicom cart. | Be-Bop High School - Koukousei Gokuraku Densetsu Model DFC-EP | 1988 | Data East Corp. Japan |
| Nintendo Famicom cart. | Captain Silver Model GTS-CK | 1988 | Tokuma Shoten Intermedia, Inc. Japan |
| Nintendo Famicom cart. | Captain Tsubasa Model TCF-TP | 1988 | Tecmo, Ltd. Tokyo, Japan |
| Nintendo Famicom cart. | Chou Wakusei Senki - Metafight Model TEC-MF | 1988 | SUNSOFT Kounan, Japan |
| Nintendo Famicom cart. | Chuugoku Senseijutsu Model SAN-CQ | 1988 | Sanritsu Japan |
| Nintendo Famicom cart. | Cobra Command Model DFC-CN | 1988 | Data East Corp. Japan |
| Nintendo Famicom cart. | Contra Model RC826 | 1988 | Konami Industry Co., Ltd. Japan |
| Nintendo Famicom cart. | Cosmo Police GALIVAN Model NBF-GV | 1988 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| Nintendo Famicom cart. | Cycle Race Roadman - Gekisou!! Nihon Isshuu 4000km Model TKS-G7 | 1988 | Tokyo Shoseki |
| Nintendo Famicom cart. | Daisenryaku Model BTC-DY | 1988 | Bothtec, Inc. Japan |
| Nintendo Famicom cart. | Deep Dungeon III - Yuushi e no Tabi Model SQF-UT | 1988 | Square Co., Ltd. Japan |
| Nintendo Famicom cart. | Deja Vu - Akumu wa Hotouni Yatte Raita Model KSC-DG | 1988 | Kemco, Ltd. |
| Nintendo Famicom cart. |  Densetsu no Kishi ELROND Model NMK-ER | 1988 | JALECO Co., Ltd. Japan |
| Nintendo Famicom cart. | Dokuganryuu Masamune Model NAM-DG-5500 | 1988 | NAMCOT Japan |
| Nintendo Famicom cart. | Donald Duck Model KSC-WS | 1988 | Kemco, Ltd. |
| Nintendo Famicom cart. | Donald Land Model DFC-DX | 1988 | Data East Corp. Japan |
| Nintendo Famicom cart. | Double Dragon Model TJC-WD P | 1988 | Technos Japan Corp. Japan |
| Nintendo Famicom cart. | Dragon Ball - Dai Maou Fukkatsu | 1988 | Bandai Co., Ltd. Japan |
| Nintendo Famicom cart. | Dragon Quest III - Soshite Densetsu e... Model EFC-D3 | 1988 | Enix, Ltd. Japan |
| Nintendo Famicom cart. | Eggerland - Meikyuu no Fukkatsu Model HAL-EG | 1988 | HAL Laboratory, Inc. Japan |
| Nintendo Famicom cart. | Elysion | 1988 | Tokyo Shoseki |
| Nintendo Famicom cart. | Erika to Satoru no Yume Bouken Model NAM-YB-4900 | 1988 | NAMCOT Japan |
| Nintendo Famicom cart. | Famicom Meijin Sen | 1988 | SNK Corp. Shin Nihon Kikaku Japan |
| Nintendo Famicom cart. | Famicom Wars Model HVC-FW | 1988 | Nintendo Co., Ltd. Japan |
| Nintendo Famicom cart. | Family Circuit | 1988 | NAMCOT Japan |
| Nintendo Famicom cart. | Family Mahjong II - Shanghai e no Michi | 1988 | NAMCOT Japan |
| Nintendo Famicom cart. | Family Quiz - 4-nin wa Rival | 1988 | Athena Co., Ltd. Japan |
| Nintendo Famicom cart. | Family Trainer 9 - Totsugeki! Fuun Takeshi-Jou 2 | 1988 | Bandai Co., Ltd. Japan |
| Nintendo Famicom cart. | Fantasy Zone II - Opa-Opa no Namida Model SS12-5500 | 1988 | SUNSOFT Kounan, Japan |
| Nintendo Famicom cart. | Fighting Golf Model SFX-FI | 1988 | SNK Corp. Shin Nihon Kikaku Japan |
| Nintendo Famicom cart. | Fighting Road | 1988 | Toei Animation Co., Ltd. Japan |
| Nintendo Famicom cart. | Final Fantasy II Model SQF-FY | 1988 | Square Co., Ltd. Japan |
| Nintendo Famicom cart. | Final Lap | 1988 | NAMCOT Japan |
| Nintendo Famicom cart. | Fleet Commander | 1988 | ASCII Corp. Japan |
| Nintendo Famicom cart. | Fudou Myouou Den Model TFC-FM-5900 | 1988 | Taito Corp. Japan |
